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Showing 1 to 20 of 78 for “"Glomerular filtration"”.
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Dynamics of the glomerular filtration barrier - Physiological and pathophysiological aspects
The dynamic properties of the glomerular filtration barrier (GFB) are of fundamental importance for the understanding of the physiology and pathophysiology of microalbuminuria and proteinuric diseases. In the studies of this doctoral thesis the properties of the rat glomerular filtration barrier …
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Evaluation of iohexol clearance to estimate glomerular filtration rate in normal horses
… under certain conditions. Estimation of the glomerular filtration rate (GFR), accepted as one of the earliest and most sensitive assessments of renal function, can be determined in horses using standard techniques such as endogenous or exogenous renal creatinine clearance. These techniques …
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Evaluation of Iohexol Clearance to Estimate Glomerular Filtration Rate in Normal Horse Foals
Estimation of the glomerular filtration rate (GFR), accepted as one of the earliest and most sensitive indicators of renal dysfunction, can be determined in horses using standard techniques In adult horses and foals, renal dysfunction can occur as a secondary complication to gastrointestinal …
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Changes of Glomerular Filtration Rate of Donated and Remnant Kidneys in A Week after Living Donor Kidney Transplantation
PURPOSE: In living donor kidney transplantation, the initial function of donor's kidneys will be split into the function of the donor's remnant kidney and the recipient's implanted kidney. The question whether the function of these remnant and implanted kidneys will change after donation and …
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Changes of parathyroid hormone and vitamin D metabolites according to glomerular filtration rate in chronic kidney disease patients
BACKGROUNDS: Disturbances of mineral metabolism are common during the course of chronic kidney disease (CKD) and lead to serious and debilitating complications unless these abnormalities are addressed and treated. While secondary hyperparathyroidism develops during the early stages of chronic …
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Influence of Pregnancy on Renal Function and Feturs in Women with Underlying Renal Disease
… through February 2006 who had been diagnosed glomerular disease by renal biopsy or were suspected as having glomerulonephritis. We analyzed changes in serum creatinine, random urine protein / creatinine, blood pressure, fetal status, and the pregnancy outcome each at the preconception state, …
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Severe acute renal failure at Groote Schuur Hospital
… to days of renal dysfunction with a reduction in glomerular filtration rate (GFR) resulting in a failure to excrete nitrogenous waste products.
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Renal tubular secretion in chronic kidney disease: description, determinants, and outcomes
… chronic kidney disease are currently assessed by glomerular filtration rate and urinary albumin excretion. Other kidney functions, such as proximal tubular secretion, are not typically quantified. Tubular secretion is capable of clearing metabolites from the blood more efficiently than filtration, …
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Single nephron structure and function, and renal effects of catecholamines in the dogfish, Scyliorhinus canicula
… muscle sphincters, intra-arterial cushions and glomerular bypass shunts in renal vasculature was found. The function of these structures is discussed in relation to patterns of renal blood flow, blood pressure and glomerular perfusion. 6. Plasma levels of the catecholamines adrenaline, …
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The role of glycoproteins in glomerular pathophysiology
… the endothelial cell surface layer for an intact glomerular filtration barrier. Loss of PGs from this layer led to increased proteinuria in rats, and analysis of human glomerular tissue and cells cultured in diabetic-like conditions revealed an altered PGs expression. Paper II focused on the role …
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Hybrid Cyclic/Linear Peptides in a Multi-Component Lipid Structure as a siRNA Delivery System
… short in vivo half-life, rapid elimination via glomerular filtration, and inability to cross cell membranes due to the hydrophilic and negatively-charged nature. Thus, a delivery system is needed to deliver the siRNA into the cells by crossing the negatively-charged phospholipid cell membrane. …
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The Pharmacokinetics of Oxytetracycline in Dogs With Normal and Impaired Renal Function
… dysfunction, defined by the percentage of normal glomerular filtration rate (GFR), was estimated by ('125)I-iothalamate total body clearance. The pharmacokinetics of oxytetracycline (OTC) were compared before and after the induction of renal failure in three experiments: single intravenous dose …
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Are gadolinium contrast media really less nephrotoxic than iodine agents in radiographic examinations? A comparison in relation to their ability to attenuate x-rays in a pig model
… GFR-marker were used to compare their effects on glomerular filtration rate 1-3 hours post-injection. III) After the experiments the kidneys were evaluated histomorphologically. Results: I) In vitro measurements indicate that 0.5M Gd-CM are equal attenuating with 60-80 mg I/mL at commonly used …
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Investigation of novel biomarkers associated with renal disease
… measures of renal function and damage (estimated glomerular filtration rate and urinary albumin to creatinine ratio). Retinal biomarkers have previously been associated with the most significant causes of chronic kidney disease (CKD), hypertension and diabetes, and the most important effect of …
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Association of variants in APOL1, MYH9 and HMOX1 WITH micro-Albuminuria among Sickle Cell disease patients from Cameroon
… in MYH9 and APOL1, and between estimated Glomerular Filtration Rate (eGFR) and End Stage Kidney Disease (ESKD) with HMOX1 variants among adult African Americans affected by SCD. However, the association between these variants and micro-albuminuria, a primary indicator of renal dysfunction, …
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Clinico-pathological features of repeat renal biopsies in patients with lupus nephritis at Groote Schuur Hospital, Cape Town
… indication for the repeat biopsy (36.1%). The glomerular filtration rate and proteinuria worsened between the two biopsies (p=0.001 and 0.019) respectively suggesting disease progression. Most patients (65.4%) with a non-proliferative class of LN at first biopsy progressed into a proliferative …
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The Effect of Nephrotomy on Renal Function and Morphology in Normal Cats
… Population: Ten adult female cats. Methods: Glomerular filtration rate (GFR), as determined by quantitative renal scintigraphy using 99mTc-DTPA, urinalysis, urine culture, and sonographic measurement of renal size were performed pre-operatively. A left or right nephrotomy (five randomly …
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The renal effects of nonsteroidal anti-inflammatory drugs (NSAIDS) in dogs with chronic kidney disease (CKD)
… kidney including regulation of renal blood flow, glomerular filtration, renin release, and sodium excretion. Upon activation of the renin angiotensin aldosterone system (RAAS), prostaglandin upregulation becomes critical to offset the vasoconstrictive effects of norephinephrine, angiotensin II, …
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Acidosis and bone disease in chronic renal failure
… generally had a substantial reduction in glomerular filtration rate, a urine acidifying defect, and a number had clinically apparent osteomalacia. However, the association of the osteomalacia with the chronic metabolic acidosis seemed at least as strong as with the degree of uraemia, …
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Effects of a prostaglandin E₁ analogue, misoprostol, on gentamicin-induced nephrotoxicosis in dogs
… of misoprostol appeared to adversely affect glomerular filtration rates in this model of acute nephrotoxicosis in dogs. In previous studies, supplementing vasodilatory prostaglandins in experimental acute renal failure had beneficial effects or there were no changes in renal function. …
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