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Showing 1 to 17 of 17 for “"Gliotoxin"”.
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Gliotoxin Production in Aspergillus fumigatus
… many scientists suspect that the compound, gliotoxin, plays a major role, hi this study, we compared the amounts of gliotoxin produced from clinical and environmental isolates of A. fumigatus. We hypothesized that the amount of gliotoxin produced would be higher in the clinical isolates in …
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Novel Inducers of Gliotoxin Production In Aspergillus Fumigatus
… factors and developmental processes. Gliotoxin, which is produced by a variety of <em>Aspergillus</em> species, <em>Trichoderma</em> species, and <em>Penicillium</em> species, exhibits immunosuppressive properties and has therefore been the subject of research for many laboratories. …
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Regulatory and self-protection implications of gliotoxin bisthiomethylation in Aspergillus fumigatus
Gliotoxin is an epipolythiodioxopiperazine (ETP) produced by the opportunistic fungal pathogen Aspergillus fumigatus. It contains an intact disulphide bridge, which mediates its toxic effects via redox cycling. Like many other ETPs, a bisthiomethylated form is also produced. In the case of …
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Characterising the response to gliotoxin exposure in Aspergillus fumigatus ΔgliT and ΔgliZ
The non-ribosomal peptide gliotoxin, is a toxic fungal secondary metabolite produced by the filamentous fungus Aspergillus fumigatus. Previous work has implicated its potent anti-fungal properties and importance as a virulence factor in human infection. Availability of the A. fumigatus genome has …
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The Glutathione S-Transferase GliG Mediates Gliotoxin Biosynthesis, not Self-Protection, in Aspergillus fumigatus: A Functional Genomic Investigation.
Gliotoxin is an epipolythiodioxopiperazine produced by the opportunistic fungal pathogen Aspergillus fumigatus. It contains an intact disulphide bridge, which mediates its toxic effects via redox cycling. Gliotoxin biosynthesis is directed by the gli gene cluster, and knowledge of the biosynthetic …
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A Global and Targeted Proteomic Investigation of Aspergillus fumigatus
… involved in the interaction of A. fumigatus with gliotoxin were also examined, using phenotypic analysis, comparative proteomics and metabolomics. Gliotoxin was observed to relieve H2O2-induced stress, in a dose-dependent manner (0 - 10 μg/ml) and this correlated with a significant increase in …
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Using Saccharomyces cerevisiae to characterise the in vivo effects of exposure to the prion-curing drug Tacrine and the fungal metabolite gliotoxin
Gliotoxin is a toxic fungal metabolite that is produced by Aspergillus fumigatus, amongst other species. Gliotoxin contains a disulfide bridge that has been significantly implicated in its toxicity. Research has demonstrated that gliotoxin displays immunomodulating capacity and anti-viral activity, …
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Aspergillosis: interactions of Aspergillus fumigatus andHuman Airway Cells
… and mortality among immunosuppressed patients. Gliotoxin is a mycotoxin and a secondary metabolite of A. fumigatus. This toxin possesses immusuppresive activity affecting cells of immune system. This research shows that human adenocarcinoma alveolar epithelial cells (A549) are highly susceptible …
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An Analysis of the Response of Aspergillus fumigatus and Candida albicans to Caspofungin
… drug leads to the release of amino acids and gliotoxin. There is also an increase in internal levels of gliotoxin following exposure to the drug. Prolonged exposure to caspofungin leads to reduced growth but greatly elevated levels of secreted and internal gliotoxin. Since this toxin is highly …
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Functional Genomic Analysis of Natural Product Biosynthesis and Secretion in Aspergillus fumigatus
… siderophores and other unusual compounds such as gliotoxin. These provide the fungus with a unique strategy for survival in the host, and contribute to pathogenicity. The aim of this project was to identify interactions between non-ribosomal peptide synthetase genes (termed pes1 and sidD) and to …
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The Redox and Systems Biology of Ergothioneine Biosynthesis in Aspergillus fumigatus
… in Aspergillus fumigatus, in work pertaining to gliotoxin biosynthesis. Compared to wild-type, EGT levels were elevated in the absence of GliK, a gliotoxin biosynthetic enzyme. The work presented in this thesis demonstrates that deletion of A. fumigatus egtA (AFUA_2G15650), which encodes a …
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Investigating and exploiting fungal natural products in Aspergillus spp.
Gliotoxin (GT) is a redox-active natural product produced by some fungal species that contributes to the virulence of the human pathogen Aspergillus fumigatus. It contains a characteristic disulphide bridge responsible for the deleterious effects of this molecule. GT also displays antifungal …
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State-dependent changes in astrocyte regulation of extrasynaptic NMDA receptor signaling in neurosecretory neurons
… astrocyte glutamate transporters, as well as the gliotoxin a-aminodadipic acid, enhanced tonic INMDA and neuronal activity, supporting an astrocyte regulation of tonic INMDA strength. Dehydration, a physiological challenge known to increase SON firing activity and to induce neuroglial remodeling, …
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Analysis of the effect of atorvastatin on the virulence of Fungal Pathogens
… reduction in ergosterol synthesis, and increased gliotoxin release in A. fumigatus. Proteomic analysis revealed increased abundance of proteins associated with an oxidative stress response, ergosterol biosynthesis and secondary metabolites. Atorvastatin can be used to inhibit the growth of C. …
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Mycotoxins in indoor environments. Determination using mass spectrometry.
… or immunosuppressive and neurotoxic (e. g. gliotoxin produced by Penicillium spp. and Aspergillus spp. e. g. A. fumigatus). Airborne mycotoxins have been demonstrated in water-damaged buildings using both ELISA and mass spectrometry. However, whether mycotoxins at the concentrations found in …
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The Roles of a Conserved MAP Kinase Pathway in the Regulation of Development and Secondary Metabolism in Aspergillus Species
… metabolites such as the immunosuppressant gliotoxin, which promotes invasive pulmonary aspergillosis and this can lead to mortality rates as high as 95% in immunocompromised patients. In A. flavus, we provided evidence of the existence of a tetrameric pheromone module pathway, which is made …
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Organocatalytic asymmetric mannich-type reactions: an easy approach to optically active amine derivatives
… total synthesis of Aspirochlorine, a potent gliotoxin that recent studies indicate as a highly selective and active agent against fungi (Scheme I, right). At the beginning of 2005 I had the chance to join the group of Prof. Alfredo Ricci at the Department of Organic Chemistry of the …