Global ETD Search
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Showing 1 to 19 of 19 for “"Glioma Stem Cells"”.
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Differential Angiogenic Capability and Hypoxia Responses in Glioma Stem Cells
<p>Malignant gliomas are highly lethal cancers characterized by florid angiogenesis. Glioma stem cells (GSCs), enriched through CD133 (Prominin1) selection, are highly tumorigenic and therapy resistance. However, the mechanism through which GSCs promote tumor growth was largely unknown. As we …
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Investigating The Role Of Chaperone-Mediated Autophagy In Glioma Stem Cells
… median survival of less than 2 years. Cancer stem/propagating cells (CSCs) are functionally defined by the enriched capacity to propagate tumors in vivo, as well as self-renewal and differentiation potentials to establish cellular hierarchy and heterogeneity. Numerous studies support that GBMs …
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Atrx Inactivation and Idh1-R132H Drive Preferential Sensitivity to Proton Vs. X-Ray Radiotherapy In Glioma Stem Cells
<p><strong>Background:</strong> Glioma Stem Cells (GSCs) are self-renewable, treatment resistant cells in the glioma tumor mass known to promote tumor development. In contrast to traditional photon-based radiation therapy (XRT), proton radiation therapy (PRT) may induce more complex DNA damage and …
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Molecular Consequences of High Taz Expression In Gliomas
<p>Diffuse high grade gliomas are complex and lethal neoplasms of the adult central nervous system that are driven by a range of genetic and epigenetic alterations. Molecular classification of these tumors has identified different transcriptional subtypes, the most notable being Proneural (PN) and …
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Stemness status in differentiated and undifferentiated glioma cells
Undifferentiated cancer stem cells (CSCs) with their unique potential of self-renewal and multi-lineage differentiation fuel tumour growth and relapse. Efficacy of glioma therapy can be considerably improved if the target is focused towards successful identification and elimination of CSCs. The aim …
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Decoding mechanisms of brain tumour initiating cell adaption and tumour growth
… years beyond diagnosis, respectively. The cancer stem cell subpopulation of such tumours has been shown to be responsible for tumour initiation and to be able to recapitulate tumours upon transplantation into healthy hosts. These tumour (re)-initiation cells exhibit stem-like characteristics which …
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TO INVESTIGATE THE ROLE OF RNF8 IN REGULATING MITOTIC PROGRESSION IN GLIOMAS
… (GBM) is a lethal brain tumour that is driven by glioma stem cells (GSCs). The E3 ubiquitin ligase RNF8, an established DNA damage response factor, has been implicated in spindle assembly checkpoint (SAC) but its exact role remains unknown. Using RNF8 proximity proteomics, we find that RNF8 …
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Connecting brain tumor stem cells with their primary tumor and exploring glycogen synthase kinase -3ß regulation of cell fate
Malignant brain tumors such as gliomas can arise from a subpopulation of cells frequently called glioma stem cells (GSCs). These cells are often resistant to conventional therapies, hence are the likely culprits of tumor recurrence. Here, we describe the derivation of a human GSC line, NNI-8. Our …
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The Development of a Printable Device with Gravity-Driven Flow for Live Imaging Glioma Stem Cell Motility
… phenotypes. One cell subset in particular, glioma stem cells (GSCs), is frequently left behind in the brain parenchyma once the bulk of the tumor has been resected. Previous research has found that patient-derived GSCs displayed varying invasion responses with and without the presence of …
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Investigating The Role of Exosomal Communication In The Glioma Microenvironment
… human cancers are maintained by a population of cells with stem-like properties called cancer stem cells (CSCs). However, the influence of the surrounding stromal cells on the behavior of the CSCs remains poorly understood. We have recently shown that the micro-environment of human gliomas, the …
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Characterising Triflupromazine as a potential agent to treat glioblastoma multiforme
… poor prognosis, accounting for up to 50% of all gliomas. For decades, treatment of this tumour has been limited to surgery with concurrent radiation and chemotherapy with temozolomide (TMZ). However, recurrence is inevitable and resistance develops rapidly despite aggressive treatment regimens …
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Dissecting the function and targets of FOXG1 in glioblastoma
… These tumours comprise a mixture of neural stem cell-like cells and more differentiated astrocytic cells. The former are thought to be responsible for tumour development and recurrence, and display self-renewal and differentiation capacity in vitro. Glioma stem cells (GSCs) are defined …
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Development of a reversible quiescence model to identify signals enabling glioblastoma cancer stem cell transition between active and quiescent states
Gliomas are the most common primary brain tumour in adults with only limited therapies available. Glioma stem cells (GSCs) are a subpopulation with tumorigenic capacity associated with increased glioma malignancy, particularly in glioblastoma (GBM), the most frequent and aggressive adult glioma …
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Transcriptional and Multi-Omic Heterogeneity in Glioblastoma Stem Cells
… is strong evidence to suggest the existence of stem like cells, which we term glioma stem cells (GSCs), that are capable of repopulating the tumor after surgery and chemotherapy. Thus, any effective treatment for GBM will likely have to target this population. Evidence of functional …
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Studies Of The Molecular Mechanisms Underlying Cancer Stem Cells And The Transformed Metabolic Phenotype
… challenging disease. Recently, cancer stem cells (CSCs) and de-regulated cellular metabolism have become appreciated for their crucial roles in the development, growth, and therapy resistance of tumors, and are now being pursued as therapeutic targets for the treatment of cancer. To …
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Expression profile of multidrug resistance genes and proteins in cancerous and stem cells
… knowledge and advanced treatments of high-grade gliomas, the overall survival rate of glioma patients remains low due to the recurrences and locations of the tumour. Evidence shows that the existence of a subpopulation of cells - cancer stem cells (CSCs) may be the major obstacle in treating …
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Human Mesenchymal Stem Cell Homing to Glioma Stem Cell Xenografts
… and blood-tumor barriers to deliver anti-glioma therapeutics to the whole tumor and the microsatellite populations of tumor cells scattered throughout the brain parenchyma. However, bone marrow-derived human mesenchymal stem cells (hMSCs) offer a viable alternative to enhance therapeutic …
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Development of an Injectable Hydrogel Platform to Capture and Eradicate Glioblastoma Cells with Chemical and Physical Stimuli
… chemotherapy and radiation therapy, residual GBM cells form secondary tumors which lead to poor survival times and prognoses for patients. This tumor recurrence can be attributed to the inherent GBM heterogeneity that makes it difficult to eradicate the therapy-resistant and tumorigenic …
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Treating MTAP-Deficient Brain Tumors with Purine Synthesis Inhibition
… a feature partially imparted by tumor cell stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs, promotes stemness in GBM cells. Exploiting MTAP loss-conferred deficiency in purine salvage, we demonstrate that purine blockade via …