Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Glioma Stem Cell"”.
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Human Mesenchymal Stem Cell Homing to Glioma Stem Cell Xenografts
… and blood-tumor barriers to deliver anti-glioma therapeutics to the whole tumor and the microsatellite populations of tumor cells scattered throughout the brain parenchyma. However, bone marrow-derived human mesenchymal stem cells (hMSCs) offer a viable alternative to enhance therapeutic …
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The Development of a Printable Device with Gravity-Driven Flow for Live Imaging Glioma Stem Cell Motility
… GBM treatment in the form of therapy resistant cell subsets and influence on cellular phenotypes. One cell subset in particular, glioma stem cells (GSCs), is frequently left behind in the brain parenchyma once the bulk of the tumor has been resected. Previous research has found that …
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Taz As A Regulator of Mesenchymal Transformation and Clinical Aggressiveness In Gliomas
… TEAD, and the mesenchymal marker FN1 in human gliomas. Western analyses demonstrated increased expression of TAZ, TEAD4, and FN1 in GBM relative to lower grade gliomas. We also identified CpG islands in the TAZ promoter that are methylated in most lower grade gliomas, but not in GBMs. …
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Effect of Interstitial Fluid Flow and Radiotherapy on Glioblastoma Invasiveness and Progression
… (GBM) is the most aggressive and malignant glioma. It accounts for 48.6% of all primary, malignant gliomas with a median survival of 15 months. Infiltration into the surrounding parenchyma is a hallmark of GBM. Radiotherapy is used to address the invasion; however, recent studies have …
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High-Throughput Mapping of The Biological Effects of Particle Therapy
… by our group, RBEs of adherent lung cancer cell lines at 12 positions along proton beams at the MD Anderson Proton Therapy Center (PTC) and the Heidelberg Ion Therapy (HIT) facility were measured. RBEs for helium and carbon ion beams were also measured at the HIT facility. This system was …
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Characterizing and targeting the genomic consequences of ATRX deficiency in glioma
… feature in several cancers, including malignant glioma. As standard of care only leads to transient responses and poor outcomes, there is an unmet clinical need for developing new therapies that target ATRX-deficient glioma. Loss of ATRX gives rise to abnormal G-quadruplex DNA secondary …
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Phenotypic screening and AI uncovers modulators of YAP and TAZ activity in glioblastoma
… is enhanced by phenotypic plasticity of tumour cells which allows them to differentiate and regress into multiple glial-like cell types with neoplastic traits and enhanced stem cell characteristics contributing to radio- and chemo-resistance. These stem-like cells can propagate recurrent tumours …
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Investigating The Role of Exosomal Communication In The Glioma Microenvironment
… human cancers are maintained by a population of cells with stem-like properties called cancer stem cells (CSCs). However, the influence of the surrounding stromal cells on the behavior of the CSCs remains poorly understood. We have recently shown that the micro-environment of human gliomas, the …