Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 325 for “"Glioma"”.
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Depression in glioma
… Disorder (MDD) in adults with primary cerebral glioma. Our knowledge of these important complications of glioma is currently poor. AIMS This thesis aims to answer a series of relevant clinical questions. I have studied: [1] the frequency, independent clinical associations and course of general …
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Immunotherapy for murine glioma
… would improve treatment of gliomas. An oncolytic virus encoding IL15Ra-IL15 (the T cell activating stimulus) and the prostaglandin synthesis inhibitor celecoxib (the anti-immunosuppressant) were combined with adoptive transfer of tumor-specific T cells. Two oncolytic …
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Neuronal and Electrophysiological Markers of Glioma
… the most malignant tumors of the human brain – glioma. From the early stages of my career I was confronted with the cruel reality of losing patients due to this devastating disease. The studies performed over the last four years involve extensive data analysis in different clinical and …
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Malignant Glioma: Chemosensitivity testing and Biomarkers
… two concepts to the management of malignant gliomas. Chemosensitivity testing was performed on twelve primary malignant glioma cultures at passage 0. The drugs tested were Temozolomide, Cisplatin and Carmustine, which are commonly administered chemotherapeutic agents in clinical practice in …
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Novel approaches to MRI of glioma
Gliomas are extremely heterogeneous, both morphologically and biologically, which contributes to a very poor prognosis. Current imaging of glioma is insufficient for a thorough diagnosis, therapy assessment and prognosis prediction. Moreover, refined and more sophisticated imaging technique could …
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Igfbp2 Potentiates Egfr-Stat3 Signaling In Glioma
<p>Gliomas are clinically challenging brain tumors with dismal survival rates due to its infiltrative nature and ineffective standard therapy. Insulin-like growth factor binding protein 2 (IGFBP2) is a pleiotropic oncogenic protein that has both extracellular and intracellular functions. Despite a …
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Genomic and Molecular Characterization of Brainstem Glioma
<p>Gliomas of the brainstem and closely surrounding structures are a devastating form of brain cancers with some of the highest mortality rates among all cancers. The delicate structures surrounding these tumors make surgical resection rare due to the risk of perioperative mortality or paralysis. A …
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CYTOKINE CONTROL OF GLIOMA ADHESION AND MIGRATION
… major causes of treatment failure and death from glioma, because disseminated tumor cells provide the seeds for tumor recurrence. Inflammation is increasingly recognized as an important component of invasion. In the brain, inflammation can occur by activation of microglia, the resident macrophages …
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Effect of combinations of drugs on glioma chemotherapy
… as well as the quality of life of patients with glioma. Combination chemotherapy regimens along with the use of two or more anticancer agents or with the use of various drug delivery systems have become a major component of various treatment strategies that are used to manage tumours. The current …
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HSP70: a therapeutic biomarker for treatment of glioma
Gliomas are amongst the most malignant, invasive and recurrent forms of brain tumour with very short survival rate due to high chemoresistance. Recently, highly inducible molecular chaperones HSP70 and HSP90 are emerging as important anti-cancer targets. Previously, proteomic analysis had …
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Selective targeting to glioma with nucleic acid aptamers
The term glioma encompasses brain tumours arising from the glial cells. Malignant glioma are characterised by a rapid growth rate and high capacity for invasive infiltration to surrounding brain tissue, hence diagnosis and treatment is difficult, and patient survival is poor. Aptamers are small …
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Stemness status in differentiated and undifferentiated glioma cells
… fuel tumour growth and relapse. Efficacy of glioma therapy can be considerably improved if the target is focused towards successful identification and elimination of CSCs. The aim of this research lies in defining specific and selective marker(s) to isolate glioma stem cells, to explore the …
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Glioma produced periostin attracts human neural stem cells
… well known for their migration tendency toward glioma and become attractive vehicles to deliver therapeutic genes to brain tumors. However, which factors and mechanisms in these processes are not yet known. In the present study, I aimed at identifying the chemoattractant molecules which induce …
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Comprehensive Analysis of the Molecular Underpinnings of Pediatric Glioma
… tumors affecting children. Of these CNS tumors, gliomas are the most prevalent. Currently gliomas are histologically segregated into two umbrella categories: low-grade glioma (grades 1 and 2, pLGG) and high-grade glioma (grade 3 and 4, pHGG). pLGG are the most frequently diagnosed pediatric …
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Exploring the immunologic consequences of ATRX deficiency in glioma
… ATRX-mutated tumor types is the adult-type glioma, IDH-mutant, Astrocytoma. It is known that ATRX mutation leads to increases in DNA damage, replication stress, and global epigenetic regulation at a cell level; however, less is known about the impact of ATRX mutation on immune signaling. …
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Developing computational methods to enhance understanding in glioma progression
… in a single patient for three patients with glioma and three patients with clear cell renal cell cancer. Of the six patients evaluated, two produced trees with the same topologies as those produced using traditional, alignment-based methods, two displayed minor variations and two displayed …
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The role of retinoic acid in glioma growth control
… of the central nervous system are known as gliomas, arising from the astrocytes, oligodendrocytes, ependymal cells or from glial progenitor cells. Although a relatively rare diagnosis, there is disproportionate morbidity associated with a glioma diagnosis, owing to its diffuse and …
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The mechanism of tamoxifen action on glioma cell lines
… antiproliferative effect in patients harbouring glioma. Glioma brain tumours differ from most other cancers by their diffusive invasion of the surrounding normal tissue and frequent recurrence following all forms of therapy. It is this invasive nature that ultimately contributes to their poor …
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The Identification and Validation of Novel Aptamers to Glioma
Glioma is a cancer derived from transformed glial cells; these tumours are often invasive and display a heterogeneous cell population, with various phenotypes. Current treatment modalities for glioma are ineffective, with minimal improvement to overall patient survival over the last decade. …
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