Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Gliogenesis"”.
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Neurogenesis and Gliogenesis from Ascl1 (Mash1) Expressing Progenitors in the Central Nervous System
… the physiological functions of Nicastrin in gliogenesis were investigated. Nicastrin is a requisite subunit of the !-secretase complex essential for activating Notch signaling pathway. Conditional mutant of Nicastrin leads to the increased level of oligodendrocytes lineage markers in the …
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Merlin Regulation of Mouse Spinal Cord Neural Precursor Cell Function
… activation as a key driver of NPC growth and gliogenesis in Nf2-deficient NPCs, and identify a unique mechanism for merlin growth regulation relevant to the design of future drug therapies for SC ependymomas.</p><p>Secondarily, we demonstrate that merlin loss in brainstem NPCs does not result …
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Resolving developmental dynamics using single-cell sequencing data
… description of the switch from neurogenesis to gliogenesis identifying primed cell states and branching points. I continue with an application of the forebrain atlas comparing brain development and brain cancer. After identifying the recapitulation of developmental trajectories in a mouse model …
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Elucidating Astrocytic Diversity in Human Cerebral Organoids
… the human fetal cortex and undergoes significant gliogenesis at 200DIV. In particular, two novel astrocytic populations, AC1 and AC2 are identified and validated through single cell and spatial transcriptomics. Based on newly identified markers from single-cell RNA sequencing (scRNASeq) results, …
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Elucidation of the Role of miR-184 in the Development and Maintenance of the Drosophila Melanogaster Nervous System
… that miR-184 functions to control post-embryonic gliogenesis, as well as in maintaining neuronal excitability and integrity of the Drosophila aging brain.
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The Neurogenic Capacity of Müller Glia and Synaptic Remodeling in the Mammalian Retina: Implications for Regenerative Therapies
… nonneuronal tissues, whereas Notch can promote gliogenesis during retinal development. Inhibition of Rest expression by RNA interference combined with pharmacological inhibition of Notch signaling with DAPT led to the upregulation of some additional neuronal genes in ImM10 Müller glia. Together, …
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Inflammation-associated gene regulation in primary astrocytes, glial tumors and cellular differentiation
… well as glioblastoma cells, and also regulates gliogenesis, we studied molecular mechanisms of this process in an in vitro differentiation model. We turn our attention to the NFI family of transcription factors since they have recently emerged as novel regulators of the development of vertebral …
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Astrocytes Rescue Neuronal Health After Cisplatin Treatment Through Mitochondrial Transfer.
… stem cells are important for neurogenesis, gliogenesis, and proper cognitive function. For astrocytic mitochondrial transfer to NSCs, we used an <em>in vitro</em> system consisting of mouse cortical astrocytes with DsRed-labeled mitochondria that were co-cultured with mouse NSCs. We observed …
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ADULT HUMAN BRAIN MENINGES HOST NEURAL STEM/PRECURSOR CELLS THAT CAN BE IN VITRO EXPANDED AND SHOW MULTIPOTENT NEURAL DIFFERENTIATION POTENTIAL IN 2D AND 3D CULTURE
… through the processes like neurogenesis and gliogenesis [1]. In the developed mammalian brain these NSCs have been found to be restricted to limited regions called neurogenic niches [2]. These neurogenic niches provide microenvironments for the NSCs survival, proliferation and neural …
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Novel mechanism in astrocyte gene regulation and function
… 3 (STAT3), which are known to regulate gliogenesis. Indeed, knock-down of NFI-X and STAT3 significantly reduced YKL-40 expression in astrocytes, while overexpression of NFI-X3 (a splice isoform of NFI-X) dramatically induced YKL-40 expression in glioma cells. In addition, activation of …
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The effects of complex I deficiency on neurogenesis and white matter development in a mouse model of Leigh Syndrome (LS)
Leigh syndrome (LS) is one of the most prevalent inherited mitochondrial disorders in pediatric population, typically presenting in early childhood with psychomotor regression and progressive neurological decline. Current understanding suggests that pathogenic variants affecting mitochondrial …
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Uncovering the role of notch signaling in development of hypothalamic nuclei in vivo and using in vitro microenvironments
… as cellular proliferation, neurogenesis, and gliogenesis in the developing AVPV. In order to better understand the direct effects Notch signaling has on early fate decisions of progenitors of the hypothalamus, we next utilized a primary progenitor culture system consisting of late progenitor …
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Lithium and brain plasticity - studies on glial cell changes and electroconvulsive treatment-induced amnesia in rats
Depression and bipolar disorder, collectively known as mood disorders, are devastating, common and often chronic illnesses. Imaging studies of patients with mood disorders have demonstrated structural changes in several brain regions implicated in mood regulation. Furthermore, bipolar disorder is …
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A Glial Role in the Action of Electroconvulsive Therapy
The aim of the current thesis was to investigate glial responses to electroconvulsive seizures (ECS), an animal model of the fast-acting antidepressant treatment electroconvulsive therapy (ECT). Depression, a common and devastating disorder, has in recent years been associated with volumetric …
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Molecular Mechanisms Regulating Fate Determination of Cerebral Cortex Precursors
During development of the mammalian nervous system, neural stem cells generate neurons first and glia second, thereby allowing the initial establishment of neuronal circuitry, and subsequent matching of glial numbers and position to that circuitry. Multiple molecular mechanisms act in concert to …
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Developmental Expression of Rat Target of the Antiproliferative Antibody (rTAPA) Protein in the Brain
<p>The present study defines the expression pattern of rTAPA (CD81) in the developing rat brain. rTAPA is a member of the tetramembrane spanning family of proteins, and like other members of this family, appears to be associated with the stabilization of cellular contacts. On immunoblots of the …