Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Glioblastomas"”.
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Supramolecular Structure-Enabled Delivery of Porphyrin to Glioblastomas Beyond the Blood-Brain Barrier
… surgical, radiation and chemo-therapies, glioblastomas remain incurable with a mere 6.8% five-year survival rate. This poor prognosis is rooted in treatment resistance and diffuse infiltration of cancer cells beyond surgical margins, leading to incomplete tumour resection, inevitable …
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LOCO-REGIONALLY TARGETING INTERLEUKIN-13 RECEPTOR ALPHA-2 AND MAXIMIZING THERAPEUTIC ACCESS TO GLIOBLASTOMAS USING BIOMARKER DIRECTED ALPHA PARTICLES
Currently approved conventional therapies for glioblastoma (GBM) patients have only increased their overall survival by about 20.8 months without providing a substantial benefit to their quality of life. Personalized medicine by targeting biomarkers that are overexpressed specifically by patients’ …
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An NMR study of human brain tumours: Phosphorus chemical shift imaging in vivo and high resolution proton spectroscopy of biopsy samples.
… PDE/ATP and PME/ATP were found to be higher in glioblastomas and astrocytomas than in normal brain. Pi/ATP and PCr/ATP were also high in astrocytomas. The pH of brain tumours ranged from alkaline to neutral, with meningiomas consistently having alkaline pH. A three dimensional localization …
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Pathological, Immunohistochemical and Molecular Analysis of Recurrent Glioblastoma
… most malignant neoplasm of the brain. Most of glioblastomas recur or progress despite primary treatments. However, clinical significance of pathologic diagnosis of recurrent glioblastoma is controversial. To evaluate the prognostic value of the volume of residual viable tumor versus …
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THE EFFECT OF SILENCING THE WILMS' TUMOR 1 GENE ON THE RADIATION SENSITIVITY OF GLIOBLASTOMA CELLS
Glioblastomas are among the most devastating of human cancers with a median survival of only 9-12 months. This type of brain tumor is incurable, largely due its remarkable proliferative capacity and resistance to current treatments. High levels of the Wilms' Tumor 1 (WTI) gene have been identified …
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A Cell-Based Model to Study Factors that Drive Diffuse Astrocytoma Development
… sequencing has found that secondary glioblastomas have a distinct genetic profile from the more common primary glioblastomas, which are diagnosed in people typically over the age of 60. Over 80% of secondary gliomas contain an IDH1R132H mutation, resulting in neomorphic mutations, …
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MiR-128 controls the activity of Polycomb Repressor Complexes 1 and 2 in Neural Stem Cells: Implications of its loss in gliomagenesis.
… and SUZ12/BMI1 show opposite expression in human glioblastomas versus normal brain and in glioma stem-like versus neural stem cells. MiR-128 expression is significantly reduced in the brain of young mice genetically engineered to develop glioblastomas before tumor development, as compared to the …
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The Investigation of Targets for Therapy in Brain Tumours
… All data of 26 high-grade gliomas (20 primary glioblastomas, 2 secondary glioblastomas, and 4 grade III astrocytomas including medical history of the patients were analysed using hierarchical clustering analysis (HCA) and principal component analysis (PCA) employing multivariate statistics. Two …
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A three-dimensional agent-based model of glioblastoma with applications towards in vitro and in vivo therapy simulation
… status. Despite these behavioral differences, glioblastomas are treated using a uniform standard of care regardless of tumor subtype. To identify subtype-dependent features influencing tumor progression and response to treatments, we developed a three-dimensional agent-based model of …
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Úloha cytokinů v podpoře maligních vlastností glioblastomů
The tumor microenvironment of Glioblastomas (GB) is very complex and transforms throughout radiotherapy and chemotherapy, posing a favourable environment for the malignant properties of GB including invasivity, which promotes aggressive recurrency of the tumor. These changes in the tumor …
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EXAMINATION OF CD133 AND CD147 AS CANCER STEM CELL MARKERS
… common and most malignant primary brain tumor. Glioblastomas are characterized by their ability to evade treatment on many fronts, thus a novel approach to curative therapies is imperative. A population of cells with stem cell-like properties are found within glioblastoma tumors and drive their …
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Expresión en la retina y células tumorales de genes y proteínas asociados a distrofias neuromusculares congénitas
… de mamíferos y líneas celulares derivadas de glioblastomas humanos. Mediante Western blotting se ha demostrado que el gen POMGNT2 se expresa a nivel de proteína en todas las retinas de mamíferos estudiadas (mono, vaca, rata y ratón), así como en la línea celular de fotorreceptores 661W. …
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Functional Consequences of Matrix Metalloproteinase-1 Over-Expression in Human Gliomas
… recent advancements in conventional therapies, glioblastomas remain incurable, largel y due to their ability to invade surrounding tissue. Matrix metalloproteinases are thought to contribute to the invaseive phenotype of human gliomas. Absent in normal brain, matrix metalloproteinase-1 (MMP-1) …
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Analysis of markers of cell division cycle, apoptosis and autophagy flux in glioblastoma
Glioblastomas are the most aggressive and most common type of primary brain neoplasms and are associated with poor prognosis despite advances in surgical and oncological treatments. Currently available treatments include surgical resection, fractionated external beam radiotherapy and chemotherapy. …
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Immunotoxin Monotherapy and Combinatorial Therapy With Immune Checkpoint Inhibitors for Malignant Brain Tumors
… III (EGFRvIII), two overexpressed proteins in glioblastomas. NZ-1-IT reacts with podoplanin (PDPN), a protein that has a high expression in glioblastomas and medulloblastomas. </p><p>In vitro cytotoxicity data shows that both ITs effectively inhibited protein synthesis in a variety of …
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Modelling brain tumours with network neurosciences and deep learning
… 2. To address the heterogeneous disruption of glioblastomas, I classified the regions of brain networks into different categories according to their locations. In particular, the disruption in distantly connected regions was significantly associated with patient performance, cognition, and …
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Peptide-Functionalized Layer-by-Layer Nanoparticles Demonstrate Improved Blood Brain Barrier Permeability for Glioblastoma Treatment
The greatest obstacle in the treatment of glioblastomas is the blood-brain barrier (BBB), the endothelial cells that line the vessels of the brain and are stitched together into a barrier by tight junction complexes. One approach to overcoming this barrier is encapsulating drugs in nanoparticles …
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Untersuchungen zur Rolle von Neurozytokinen in Hirntumoren
… In the majority of the examined astrocytomas and glioblastomas prominent CNTF-R alpha mRNA expression was detected. Likewise, two of four glioblastoma cell lines expressed CNTF-R alpha. Quantitative analysis of the performed northern blots revealed no significant elevated CNTF-R alpha levels of …
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Caracterización molecular en pacientes con tumores cerebrales de estirpe glial
… delecciones de la porción centromérica de 1p en glioblastomas parece que pueden estar asociadas a un subgrupo de mejor pronóstico. La presencia de EGFRvIII en glioblastoma muestra relación con una supervivencia menor. Podemos concluir que en la actualidad existen marcadores moleculares de interés …
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Preclinical evaluation of pharmacological strategies designed to enhance the activity of established and novel anti-cancer drugs. Synopsis: Evaluation of pharmacological strategies designed to modulate the Warburg effect, enhance the activity of tyrosine kinase inhibitors and novel analogues of Temozolomide.
… (TMZ) is an important drug in the treatment of glioblastomas but its activity is reduced by resistance mechanisms including O6 methyl guanine methyltransferase (MGMT) and mismatch repair (MMR). This thesis has identified analogues of TMZ (EA02-45, EA02-59, EA02-64 and EA02-65) that are MGMT and …
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