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Showing 1 to 20 of 91 for “"Glioblastoma multiforme (GBM)"”.

  1. Measuring mass changes in single suspended and adherent cells, with applications to personalized medicine in Glioblastoma Multiforme (GBM)

    Chou, Nigel ShijieMassachusetts Institute of Technology2017

    … adapt mass accumulation measurements for use in Glioblastoma Multiforme (GBM) patient-derived cell lines, exploring the heterogeneity between and within patient tumors, and validating the measurement as a predictor of drug susceptibility with response times on the order of 24 to 48 hours using an …

    mit Repository record

  2. SELECTION/CONSTRUCTION AND CHARACTERIZATION OF NOVEL PEPTIDE AND RECOMBINANT PROTEIN AGENTS TARGETING INTERLEUKIN 13 RECEPTOR ALPHA 2 IN GLIOBLASTOMA MULTIFORME

    Pandya, Hetal VinodWake Forest University2011

    Glioblastoma multiforme (GBM) is a primary brain tumor of dismal prognosis. Patients with GBM have a median survival rate of 14.5 months inspite of multimodality treatment involving surgery, radio- and chemotherapy. This warrants an intensive search for efficient new therapies. Interleukin 13 …

    wfu Repository record

  3. Epidermal Growth Factor Receptor Induces Fyn Expression Via Up-Regulation of P47Phox In Glioblastoma Multiforme

    Johnson, Blake P2015

    … are commonly over-expressed and/or activated in glioblastoma multiforme (GBM), where they serve as key mediators of GBM cell proliferation, survival, invasion and angiogenesis. Mechanisms of allosteric SFK activation are well described; however, the SFK Fyn is commonly up-regulated at the mRNA …

    uthsc Repository record

  4. IDENTIFICATION OF HCMV UL97 IN GBM CELL LINES AND A POSSIBLE ROLE FOR GANCICLOVIR

    McFall, Thomas2016

    <p>Glioblastoma multiforme (GBM) is the most common form of malignant glioma, comprising 80% of all malignant gliomas. Recently, active Human Cytomegalovirus (HCMV) was identified in GBM cells, and has been a topic of debate concerning its role with tumor progression. This study used three …

    nmu Repository record

  5. Functional Consequences of Matrix Metalloproteinase-1 Over-Expression in Human Gliomas

    Mullet, Emily2014

    … recent advancements in conventional therapies, glioblastomas remain incurable, largel y due to their ability to invade surrounding tissue. Matrix metalloproteinases are thought to contribute to the invaseive phenotype of human gliomas. Absent in normal brain, matrix metalloproteinase-1 (MMP-1) …

    vcu Repository record

  6. Identifying Cancer Subtypes Using Unsupervised Deep Learning

    Mallavarapu, Tejaswini2020

    <p>Glioblastoma multiforme (GBM) is the most fatal malignant type of brain tumor with a very poor prognosis with a median survival of around one year. Numerous studies have reported tumor subtypes that consider different characteristics on individual patients, which may play important roles in …

    kennesaw Repository record

  7. Assessment of the in vitro efficacy of aspirin and aspirin analogues in combination with standard chemotherapeutics in glioma cell lines

    Chheda, Preet BharatUniversity of Central Lancashire2014

    Glioblastoma multiforme (GBM) is the most common and most malignant primary brain tumour. The prognosis for patients remains poor with a median survival time falling well short of a year in spite of surgical removal of tumour followed by radiotherapy. GBM is resistant to the current treatment …

    cent-lancashire Repository record

  8. ASSESSING AN M MUTANT VESICULAR STOMATITIS VIRUS FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME BY DETERMINING APOPTOTIC MECHANISMS AND ANTIVIRAL RESPONSE

    Cary, Zachary DylanWake Forest University2011

    … is a potential oncolytic virus for treating glioblastoma multiforme (GBM), an aggressive brain tumor. Matrix (M) protein mutants of VSV have shown greater selectivity for killing GBM cells versus normal brain cells, compared to VSV with wild-type M protein. The goal of experiments presented …

    wfu Repository record

  9. Αvβ8 Integrin Interacts With Rhogdi1 to Regulate Rac1 and Cdc42 Activation and Drive Glioblastoma Cell Invasion

    Reyes, Steve2013

    … survival of tumors. The malignant brain cancer glioblastoma multiforme (GBM) displays invasive growth behaviors that are major impediments to surgical resection and targeted therapies. Adhesion and signaling pathways that drive GBM cell invasion remain largely uncharacterized. Here we have …

    uthsc Repository record

  10. CHARACTERIZATION OF THERANOSTIC PEPTIDES FOR GLIOBLASTOMA MULTIFORME

    Mellesmoen, Aaron2019

    <p>Glioblastoma multiforme (GBM) is a type of primary CNS tumor in which viable treatment options do not exist. Standard of care including tumor resection, chemotherapy, and radiation does little to extend the 5-year survival expectancy past 5.1%. Herein, two small-peptide molecules with inherent …

    nmu Repository record

  11. The Tumor-Suppressive Properties of Neural Stem Cells

    Passino, Ryan2015

    <p>Glioblastoma multiforme (GBM) is an aggressive central nervous system malignancy that commonly causes immune suppression in patients to avoid immune recognition and clearance. This complicates treatment options and limits the effectiveness of immunotherapy strategies. Interestingly, GBM …

    nmu Repository record

  12. Potential Rest Targets In Neural Stem Cells and Glioblastoma-Derived Stem Cells

    Robinson, Frederick Scott2012

    <p>Glioblastoma multiforme (GBM) tumors are the most common malignant primary brain tumors in adults. The current theory is that these tumors are caused by self-renewing glioblastoma-derived stem cells (GSCs). At the current time, the mechanisms that regulate self-renewal and other oncogenic …

    uthsc Repository record

  13. BASIGIN-2 MEDIATED ACTIVATION OF ERK1/2 SIGNALING IN HUMAN GLIOBLASTOMA MULTIFORME CELLS

    Peterson, Erik R2017

    <p>Glioblastoma multiforme (GBM) is the most common malignant form of human brain cancer. GBM tumor cells overexpress the protein Basigin (Bsg) at the cell surface where it contributes to malignancy via stimulation of matrix metalloproteinase (MMP) expression in surrounding normal tissues, …

    nmu Repository record

  14. NCIS: a network-assisted co-clustering algorithm to discover cancer subtypes based on gene expression

    Liu, YiyiUniversity of Illinois at Urbana-Champaign2013

    … effectiveness of the algorithm on large-scale Glioblastoma multiforme (GBM) and breast cancer (BRCA) datasets from TCGA and on simulated datasets. We found that our NCIS method can achieve more reliable results with respect to the clinical features compared to conventional semi-nonnegative …

    uiuc Repository record

  15. Investigating The Role Of Chaperone-Mediated Autophagy In Glioma Stem Cells

    Yu, Sixiang2021

    Glioblastoma multiforme (GBM) is the most common and lethal form of primary brain cancer. Despite the current standard-of-care therapies, glioblastoma remains universally fatal with median survival of less than 2 years. Cancer stem/propagating cells (CSCs) are functionally defined by the enriched …

    penn Repository record

  16. Quantitative analysis of the EGFRvIII mutant receptor signaling networks in Glioblastoma

    Huang, Hua Ming PaulMassachusetts Institute of Technology2008

    Glioblastoma multiforme (GBM) is the most aggressive adult brain tumor and remains incurable despite multimodal intensive treatment regimens. EGFRvIII is a truncated extracellular mutant of the EGF receptor (EGFR) that is commonly found in GBMs and confers tumorigenic behavior. Although much work …

    mit Repository record

  17. Endosomal Trafficking and Exosomal Secretion of Egfrviii

    Memarzadeh, Kimiya, <p>https://orcid.org/0000-0003-1737-663X</p>2020

    … is linked with approximately one third of Glioblastoma Multiforme (GBM) tumors and is associated with poor patient prognosis. Persistent signaling due to a lack of the EGFR ectodomain and inefficient degradation have been suggested to underlie the tumorgenic properties of EGFRvIII. I …

    uthsc Repository record

  18. EVALUATING THE EFFECTS OF FASTING CONDITIONS IN COMBINATION WITH TEMOZOLOMIDE FOR THE TREATMENT OF GLIOBLASTOMA MULTIFORME

    Duffy, Joseph2020

    <p>Glioblastoma multiforme (GBM) is the most aggressive and lethal form of adult brain cancer. The standard of care for GBM is maximal surgical resection followed by adjuvant treatment with the chemotherapeutic agent temozolomide (TMZ) and radiotherapy. O-6-methylguanine-DNA methyltransferase …

    nmu Repository record

  19. Immunotherapy against malignant brain tumors - of mice and men

    Enell Smith, KarinDepartment of Clinical Sciences, Lund University2008

    Glioblastoma Multiforme (GBM) is the most abundant and most aggressive primary brain tumor in adults. Due to the infiltrative growth of the tumor, surgery will never be radical. Radiation and chemotherapy only marginally improve the poor prognosis due to the ability of the GBM to develop resistance …

    lund Repository record

  20. Establishing a Mouse Model of Glioblastoma (GBM) And Developing Strategies to Eliminate Cancer Cells.

    Baidoo-Kanneh, Juliet N.E.The Graduate School and University Center of The City University of New York2023

    … States with a 6.8% five-year survival rate, glioblastoma multiforme (GBM) is a very deadly disease with a poor prognosis. Therefore, a curative treatment is in high demand. Among the widely used anti-metabolites (Chemotherapeutic agents, CAs), each compound approved for human use by the Food …

    cuny-grad Repository record

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