Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Glioblastoma Treatment"”.
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CD147 AS A POTENTIAL THERAPEUTIC TARGET IN GLIOBLASTOMA TREATMENT
<p>Glioblastoma (GBM) tumors are the most common and lethal form of cancer in the central nervous system (CNS). GBM tumors appear to contain a mixture of different cell types, which makes them difficult to treat. GBM cells exhibit altered morphology from normal cells on several different levels, …
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In-vitro Glioblastoma Treatment Focusing on Convection Enhanced Delivery
Glioblastoma is a deadly brain cancer with discouraging standard of care. New methods like convection enhanced delivery and chimeric antigen receptor T cells (CAR-T) are promising treatments that can be translated to glioblastoma. In this study, CAR-T cell flow through a hydrogel was explored in …
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Exploring Cancer Stem Cells (CSCs) pathways to design novel therapies for glioblastoma treatment
Glioblastoma multiforme (GBM) is the most aggressive and common form of primary brain tumor in adults, with a median survival rate of 14 months (Taphoorn et al.;2005 ). GBM is characterized by rapid diffusely infiltrative growth and high level of cellular heterogeneity, which are fueled by …
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Peptide-Functionalized Layer-by-Layer Nanoparticles Demonstrate Improved Blood Brain Barrier Permeability for Glioblastoma Treatment
The greatest obstacle in the treatment of glioblastomas is the blood-brain barrier (BBB), the endothelial cells that line the vessels of the brain and are stitched together into a barrier by tight junction complexes. One approach to overcoming this barrier is encapsulating drugs in nanoparticles …
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THERANOSTIC PLATINUM-BASED COMPLEXES FOR GLIOBLASTOMA TREATMENT AND EVALUATION OF THEIR LOADING AND RELEASE FOR DRUG DELIVERY
Il glioblastoma multiforme (GBM), il tumore al seno triplo negativo (TNBC) e l’adenocarcinoma duttale pancreatico (PDAC) appartengono ad una categoria di tumori conosciuta come tumori orfani. I tumori orfani sono estremamente rari, rappresentano meno dell’1% del numero totale di tumori umani, in …
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Multimodal Imaging of Protein-Based Biomaterials for Delivering Chemo-Agent Cargo for Glioblastoma Treatment in a Murine Model
… delivery carriers in a xenograft mouse model of glioblastoma multiforme (GBM).</p> <p>The primary objective was to compare the effectiveness of TRAP-loaded Dox (TRAP-DOX) to free Dox in achieving tumor extravasation and accumulation, facilitating sustained drug release. We hypothesized that the …
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Polymer Nanoparticle Characterization and Applications for Drug Delivery
… than a day, which is not conducive to long-term treatments. Controlling its release into the body over several weeks can decrease the number of doses required, which is especially useful for glioblastoma treatment. Poly(lactic-co-glycolic acid) (PLGA) is often used for drug encapsulation since it …
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CHARACTERIZATION OF THERANOSTIC PEPTIDES FOR GLIOBLASTOMA MULTIFORME
<p>Glioblastoma multiforme (GBM) is a type of primary CNS tumor in which viable treatment options do not exist. Standard of care including tumor resection, chemotherapy, and radiation does little to extend the 5-year survival expectancy past 5.1%. Herein, two small-peptide molecules with inherent …