Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Glioblastoma Stem cells"”.
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Transcriptional and Multi-Omic Heterogeneity in Glioblastoma Stem Cells
Glioblastoma Multiforme (GBM) is a disease with terrible prognosis, having a median survival time of ~12-15 months for patients undergoing current treatment regimens, and a 5-year survival rate under 10%. There is strong evidence to suggest the existence of stem like cells, which we term glioma …
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Bioconjugate Strategies for Antisense Therapeutic Delivery to Glioblastoma Stem Cells
… The delivery of antisense therapeutics to target cells presents a significant challenge due to the many barriers a nucleic acid must face in order to reach the cytoplasm where it exerts its effects. In this thesis, I explored multiple strategies for delivery of AONs and siRNAs, focusing on …
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Rest Regulatory Circuit Controls Distinct Oncogenic Properties of Glioblastoma Stem Cells Through Specific Micrornas
<p>Glioblastoma Multiforme (GBM) is the most common and aggressive primary malignant brain tumor in adults. With an average survival of only 12-16 months the prognosis for GBM patients remains dismal, with less than 5% of patients surviving 5 years. New mechanism-based approaches are necessary for …
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The Role of Glutamine and Mevalonate Pathway In Affecting The Stemness and Viability of Glioblastoma Stem Cells
<p><strong> </strong>Glioblastoma (GBM) remains the deadliest form of brain tumors. The poor prognosis of glioblastoma patients is associated with a high rate of relapse after therapy. It has been suggested that the presence of cancer stem cells, which are relatively resistant to radiation and …
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Function and Mechanism of Alkbh5 In N6-Methyl-Adenosine Rna Modification In Glioblastoma
… found that ALKBH5 is highly expressed in human glioblastoma stem cells which are resistant to conventional therapy and give rise to glioblastoma recurrence by sustaining long-term tumor growth. Global manipulation of the m<sup>6</sup>A modification by depleting ALKBH5 resulted in altered gene …
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Low Reactive Oxygen Species and High Glycolysis In Glioblastoma Stem Cells:Mechanisms and Therapeutic Implications
<p>Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor with poor prognosis due in part to drug resistance and high incidence of tumor recurrence. The drug resistant and cancer recurrence phenotype may be ascribed to the presence of glioblastoma stem cells (GSCs), …
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New therapeutic and diagnostic strategies in glioblastoma: Cancer Stem Cells targeted by monoclonal antibody
… for its maintenance. These undifferentiated cells are called Cancer Stem Cells (CSC) or tumor-initiating cells. A direct consequence of the CSC hierarchical model applied to clinic is that is currently taking place the idea that the traditional cancer treatment concern only the bulk tumor and …
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Alteration of differentiation in glioblastoma: from spatial transcriptomics approaches to the identification of a suppressor event
Glioblastoma is one of the most devastating forms of primary brain tumor, with a survival of 14.6 months from the diagnosis. Despite the aggressive treatments used in the clinic, consisting of surgical resection followed by radiotherapy and concurrent chemotherapy using temozolomide, the absence of …
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Regulation of cell cycle and differentiation by ASCL1 in Glioblastoma
Glioblastoma multiforme (GBM) is the most aggressive primary brain tumour in adults, as well as the most common. The current standard therapy is maximal safe resection, followed by radiotherapy in combination with the alkylating agent, temozolomide. Despite this multi-model treatment approach, …
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LINKING TRANSCRIPTIONAL AND MORPHOLOGICAL HETEROGENEITY TO THERAPEUTIC VULNERABILITIES IN GLIOBLASTOMA
… subtype-specific therapeutics vulnerabilities in Glioblastoma (GBM). Particularly, in an initial phase of my activities, I have designed and implemented computational methods for reliability and reproducibility assessment of “essentiality profiles” from genome-wide recessive pooled CRISPR-Cas9 …
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Dissecting the function of MYEF2 in neural stem cells and glioblastoma
Glioblastoma (GBM) is the most common malignant primary brain tumour in adults, with a median survival time of approximately ~15 months after diagnosis. GBM stem cells (GSCs) underpin GBM’s aggressiveness, resistance to radiation and chemotherapy, and disease recurrence. Glioblastoma stem cells …
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Bioengineering of Heterogenous Glioblastoma Multiforme Microenvironment
Glioblastoma (GBM) is the most aggressive brain tumor that originates from glioblastoma stem cells (GSCs). In the brain, GSCs are supported by a tumor microenvironment (TME) wherein the perivascular niche and hypoxic region are present. The glioblastoma microenvironment (GBME) exhibits high …
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Exploring Cancer Stem Cells (CSCs) pathways to design novel therapies for glioblastoma treatment
Glioblastoma multiforme (GBM) is the most aggressive and common form of primary brain tumor in adults, with a median survival rate of 14 months (Taphoorn et al.;2005 ). GBM is characterized by rapid diffusely infiltrative growth and high level of cellular heterogeneity, which are fueled by …
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Rational identification of a dual inhibitor of PARP-1 and ATM kinase
… that are targetable and are specific to cancer cells, which can be exploited by DDR inhibitors. PARP inhibitors are used to exploit the synthetic lethality between pharmacological inhibition of PARP (poly-ADP ribose polymerase) and BRCA (breast cancer gene) defects leading to successful patient …