Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 86 for “"Glioblastoma (GBM)"”.
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Establishing a Mouse Model of Glioblastoma (GBM) And Developing Strategies to Eliminate Cancer Cells.
… States with a 6.8% five-year survival rate, glioblastoma multiforme (GBM) is a very deadly disease with a poor prognosis. Therefore, a curative treatment is in high demand. Among the widely used anti-metabolites (Chemotherapeutic agents, CAs), each compound approved for human use by the Food …
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LIQUID BIOPSY IN GLIOBLASTOMA (GBM)CHARACTERIZATION OF PLASMA EXTRACELLULAR VESICLES CONCENTRATION, SIZE AND CARGO FOR NON-INVASIVE GBM DIAGNOSIS, MONITORING AND IDENTIFICATION OF CIRCULATING BIOMARKERS
Glioblastoma (GBM) is a highly aggressive brain tumor that presents extensive heterogeneity and high recurrence rates. Current diagnostic and monitoring approaches, primarily relying on MRI and tissue biopsies, have limitations. MRI sensitivity is limited, and tissue sampling is invasive and may …
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Establishing Intratumoral Modulation Therapy as a New Treatment Modality for High Grade Gliomas
Glioblastoma (GBM) is the most common and lethal primary brain cancer in adults despite aggressive treatments with surgery and chemo-radiation. Advances in electrotherapeutics offer a foundation for developing new treatment modalities that exploit an innate vulnerability of glioblastoma (GBM). Low …
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Molecular characterization of T cells across disease states in the central nervous system
… in the context of multiple sclerosis (MS) and glioblastoma (GBM) using a combination of immunophenotyping and functional approaches, including ultra low-input transcriptional profiling. First we use a series of unbiased approaches to identify functional differences between auto-reactive T cells …
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TO INVESTIGATE THE ROLE OF RNF8 IN REGULATING MITOTIC PROGRESSION IN GLIOMAS
Glioblastoma (GBM) is a lethal brain tumour that is driven by glioma stem cells (GSCs). The E3 ubiquitin ligase RNF8, an established DNA damage response factor, has been implicated in spindle assembly checkpoint (SAC) but its exact role remains unknown. Using RNF8 proximity proteomics, we find that …
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Novel Drug Discovery for Glioblastoma Multiforme Using Brain Tumour Initiating Cells
Glioblastoma (GBM) is the most common and aggressive adult primary brain tumour. Populations of cells with tumour initiating capacity, termed brain tumour initiating cells (BTICs), are thought to underlie the formation, growth and recurrence of GBM. As such, therapies that target this compartment …
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Analysis of NFI-X3 and STAT3 Interaction and Its Functions
… protein that is highly up-regulated in malignant glioblastoma (GBM). Its expression is correlated with the invasive nature of GBMs and poor diagnosis of patients (Nigro et al., 2005). Previous research has shown that in astrocytes and GBM cells, YKL-40 expression is regulated by two transcription …
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DEVELOPING SURFACE-MODIFIED LANTHANIDE-DOPED NANOPARTICLES AS A BRAIN TUMOR THERANOSTICS
Glioblastoma (GBM), a grade IV astrocytoma is highly aggressive and lethal. Recently, nano-based systems were widely used in GBM studies because of the ability to traverse the blood-brain-barrier successfully. However, there are still several major challenges. Lanthanide-doped nanoparticles …
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CD147 AS A POTENTIAL THERAPEUTIC TARGET IN GLIOBLASTOMA TREATMENT
<p>Glioblastoma (GBM) tumors are the most common and lethal form of cancer in the central nervous system (CNS). GBM tumors appear to contain a mixture of different cell types, which makes them difficult to treat. GBM cells exhibit altered morphology from normal cells on several different levels, …
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Signaling at the Tumor-Immune Interface in Glioblastoma
Glioblastoma (GBM) is a devastating brain cancer, and the standard of care has not changed in over 20 years. GBM tumors are composed of a milieu of cancer cells and innate immune cells, which are co-opted by the cancer cells to promote an anti-inflammatory environment. Despite tremendous success in …
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IN VITRO MODEL OF GLIOBLASTOMA TO STUDY THE EFFECTS OF BRAIN MICROENVIRONMENT AND ITS MECHANICAL PROPERTIES ON TUMOR CELLS
Glioblastoma (GBM) is one of most aggressive forms of brain cancer with a median survival rate of 14.6 months, and the two-year survival rate is 30%, which has not seen significant improvement in the last 100 years. This low survival rate could be in part attributed to the fact that there is a lack …
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Transcriptional Analysis of Reciprocal Tumor-Microenvironment Interactions in Glioblastoma
… and therapeutic responses. Interactions between glioblastoma (GBM) cells and endothelial cells (ECs) establish a purported stem cell niche. We hypothesized that genes that mediate these interactions would be important, particularly as therapeutic targets. Using a novel computational approach to …
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Treating MTAP-Deficient Brain Tumors with Purine Synthesis Inhibition
<p>Glioblastoma (GBM) is a lethal brain cancer exhibiting high levels of drug resistance, a feature partially imparted by tumor cell stemness. Recent work shows that homozygous MTAP deletion, a genetic alteration occurring in about half of all GBMs, promotes stemness in GBM cells. Exploiting MTAP …
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NOVEL PERIPHERALLY DERIVED NEURAL-LIKE STEM CELLS AS DRUG DELIVERY VEHICLES FOR GLIOBLASTOMA
Glioblastoma (GBM) is an aggressive primary malignant astrocytoma characterized by infiltrating margins and angiogenesis. Standard treatment options such as radiation and chemotherapy have proven to be partially effective in treating GBM and its recurrence. Stem cells have been shown to migrate to …
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T Cell Exhaustion in Glioblastoma
<p>Glioblastoma (GBM) is the most common primary malignant brain tumor. Despite standard of care treatment GBM remains universally lethal, demonstrating a significant need for newer treatment strategies such as immunotherapy. Immune checkpoint blockade is a type of immunotherapy which seeks to …
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Targeting tGLI1-positive Breast Cancer with Ketoconazole
… glioma-associated oncogene homolog 1 (GLI1) in glioblastoma (GBM), termed truncated GLI1 (tGLI1), that is a gain-of-function GLI1 transcription factor and demonstrates tumor-specific expression. Previous results in our laboratory have implicated tGLI1 in promoting breast cancer stem cells (CSCs) …
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Wisp1 Is An Overexpressed Driver of Glioblastoma
<p>Despite current multimodal therapies for glioblastoma (GBM) the prognosis remains very grim. There is a tremendous need to identify new genetic drivers which can serve as potential therapeutic targets. In order to find new drivers, we leveraged genomic datasets to conduct a context specific …
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The Overexpression of Basigin-3 in Glioblastoma
<p>Glioblastoma (GBM) is one of the most aggressive forms of brain tumor. With the current standard of care, survival prognosis for GBM patients is 15 months with a five-year survival rate of less than 3%. An increased understanding of the molecular mechanisms leading to cell growth and survival of …
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A Rapid Colorimetric Peptide Nucleic Acid Loop-Mediated Isothermal Amplification Assay for the Detection of the IDH1 Mutation in Glioblastoma
… and prognostic biomarker used to characterize glioblastoma (GBM). Patients harboring the <em>IDH1</em> mutation have improved overall survival following maximal resection. Knowledge of the <em>IDH1</em> mutation status allows the surgeon to modify the surgical plan; however, no existing …
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An Evaluation of Transforming Growth Factor-β Signalling in Adult Glioblastoma
<b>Introduction</b>: Adult glioblastoma (GBM) is an aggressive and fatal primary brain malignancy, for which surgery, radiotherapy and temozolomide (TMZ) have been the standard of care for over two decades. Novel therapies are required, with the ubiquitous and essential cytokine, transforming …
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