Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Glial cell line-Derived Neurotrophic Factor (GDNF)"”.
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New roles of glial cell line-derived neurotrophic factor GDNF in motor and cholinergic functions
Glial cell line-derived neurotrophic factor (GDNF) is a protein that supports dopamine neurons and regulates multiple cellular processes in the brain and peripheral systems. Because of this, GDNF holds promising potential as a disease-modifying agent for several neurological disorders, including …
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Cloning of medaka glial cell-derived neurotrophic factor (GDNF) and its receptor GFR alpha 1
Glial cell line-derived neurotrophic factor (GDNF) signaling through its receptor GFRI?1 plays an important role in many biological processes including cell survival, proliferation and differentiation. The aim of this project was to isolate and characterize both Gdnf and GfrI?1 from the medaka fish …
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Study on the Neuroprotective Effects of Ethyl pyurvate in MPTP-induced Mouse PD Models
… degeneration of nigrostriatal DA neurons and glial activation as visualized by tyrosine hydroxylase, macrophage antigen complex-1, and/or glial fibrillary acidic protein immunoreactivity. Western blotting and immunohistochemistry showed activation of microglial NADPH oxidase and astroglial …
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Selective damage to and protection of enteric neurons in vitro in models of ischemia and reperfusion
… we investigated by probing for hypoxia-inducible factor 1-α (HIF1-α) in the 2, 4, 6-trinitrobenzene sulfonic acid (TNBS)-model of colitis in adult rats. By Day 2 of TNBS-induced colitis, HIF1-α presence in the nuclei of myenteric neurons had significantly increased, indicating hypoxic challenge. …
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Epigenetic Modification of Phenotype in Intestinal Smooth Muscle Cells
… causes proliferation of intestinal smooth muscle cells (ISMC), contributing to the thickened intestinal wall and the dysmotility symptoms observed in inflammatory bowel disease (IBD). A unique consequence of Crohn’s disease (CD), a subset of IBD characterized by chronic, transmural intestinal …
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Neuroprotektion und Neurorestauration im MPTP Modell der Parkinson Erkrankung
… der substantia nigra pars compacta (SNpc). Der glial cell line-derived neurotrophic factor (GDNF) ist in präklinischen Studien als wichtiger Differenzierungs- und Überlebensfaktor für dopaminerge Neurone des Mittelhirnes identifiziert worden, jedoch hat seine Anwendung in klinischen Studien …
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Application of fluorescence resonance energy transfer to study syndecan-3 signaling on the surface of neural cells
Syndecans are cell surface heparan sulfate proteoglycans which are present in all tissues and cell types and have distinct temporal and spatial expression patterns. They play important roles in embryonic development of the organism and control relocation and alteration of extracellular matrix …
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Inflammation Promotes the Processing of Glial Cell-Line Derived Neurotrophic Factor by Matrix Metalloproteinase-9 in Intestinal Smooth Muscle Cells
… functions. Expression of the neurotrophin glial cell line-derived neurotrophic factor (GDNF) has been implicated in promoting postnatal regenerative processes in the ENS. It has been proposed that intestinal smooth muscle cells (ISMC) express GDNF as a precursor molecule that requires …
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The Role of ERK5 in Dopamine Neuronal Survival
The extracellular signal-regulated kinases (ERKs) 1, 2, and 5 play important physiological roles in neurogenesis, neutrite outgrowth, and neuronal viability in the central nervous system. In this study, ERK1, 2, and 5 expression and activation were examined in the substantia nigra (SN), striatum …
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Multi-cycle cisplatin treatment alters spermatogonial functional stem cell behavior and niche
… spermatogonia, including spermatogonial stem cells (SSCs), are theoretically capable of repopulating the seminiferous tubules after exposure has ceased. It is proposed that an altered spermatogonial environment during recovery from the initial treatment cycle may drive an increase in SSC …
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I. Advanced Fluorescent False Neurotransmitters for the Study of Monoamine Transporter Activity and Synaptic Transmission
… our group to induce the synthesis and release of Glial Derived Neurotrophic Factor (GDNF) from a model astroglial cell line. Part I consists of Chapters 1-5. Chapter 1 provides a brief introduction to the relationship between chemistry and neuroscience, while explaining the motivation and …
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Voluntary Exercise and Neurotrophin Signaling Affect the Development and Presentation of Painful Neuropathy
… thresholds. Additionally, we found that glial cell line-derived neurotrophic factor (GDNF) was decreased in the diabetic mice. These results suggest that diabetes does alter neurotrophin levels, which may lead to PDN. Next, using a high-fat diet to induce prediabetes, we found increased …
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Co-Signaling by Neurotrophic Factors and the Extracellular Matrix for Axonal Growth and Neuronal Survival
Neurotrophic factors (NTFs) and the extracellular matrix (ECM) are important regulators of axonal growth and neuronal survival in mammalian nervous system. Understanding of the mechanisms of this regulation is crucial for the development of posttraumatic therapies and drug intervention in the …
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Characterisation of Prodomains in the GDNF Family
Growth Differentiation Factor 15 (GDF15) and Neurturin (NRTN) have wide ranging roles in biology, with potential applications in diseases such as diabetes and obesity. As members of the glial cell line derived neurotrophic factor (GDNF) family, both GDF15 and NRTN signal through the RET receptor. …
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New Therapeutic Strategies for Amyotrophic Lateral Sclerosis Treatment
… highlighted this disease as a candidate for stem cell treatment. Here we investigated whether neural induction enhances therapeutic potentials of mesenchymal stem cells (MSCs). We induced neural induction of MSCs by overexpressing Neurogenin1, a proneural transcription factor. Depending on …
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Einfluss des GDNF-Rezeptors Ret auf die Erholung des nigrostriatalen Systems im MPTP-Mausmodell der Parkinsonerkrankung
… during transfection) Rezeptors durch den Glial cell line-derived neurotrophic factor (GDNF) wurde als wichtiger Differenzierungs- und Überlebensfaktor für dopaminerge Neurone des Mittelhirns in vorklinischen Experimenten identifiziert. Diese positiven Ergebnisse führten zu klinischen …
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The role of GDNF and its receptor GFRa1 in neuronal development and function
Neurotrophic factor glial cell line-derived neurotrophic factor (GDNF), its co-receptor GDNF family receptor alpha 1 (GFRa1), and signaling receptor RET tyrosine kinase are essential to enteric nervous system (ENS) development; mice knockout for Gdnf, Gfra1 or Ret lack the whole ENS distal to the …
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The glial cell line-derived neurotrophic factor family in the olfactory system and brain
Glial cell line-derived neurotrophic factor (GDNF) family signaling has been implicated in development, survival and function of many different cell types, including neurons in the central nervous system. The family consists of four ligands [GDNF, neurturin (NTN), artemin and persephin] which bind …
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Genetic Analysis of Drosophila Stomatogastric Nervous System
… receptor tyrosine kinase, which responds to the Glial Cell Line-Derived Neurotrophic Factor (GDNF) ligand. Down syndrome patients suffer from a 100-fold increase in the incidence of HSCR (1-2%). Rather than loss-of-function mutations, HSCR in these patients is thought to be due to an extra copy …