Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 113 for “"Glial Cell"”.
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Matrix Stiffness Regulates Glial Cell Morphology and Differentiation
… of the central nervous system (CNS) and Schwann cells (SC), which perform the same function in the peripheral nervous system (PNS). The decrease of NMII activity in SC impairs their ability to establish polarity and myelinate, while its inhibition in OL enhances process branching and increases …
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The Involvement of Progesterone in Glial Cell Viability
… on the viability of hydrogen peroxide stressed glial cells. We wanted to determine the extent in which varying concentration of ethynodiol diacetate affect cell viability of cultured glial cells from hydrogen peroxide toxicity. Based on previous studies, we predicted that the viability of …
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The role of complex gangliosides in glial cell biology
… rafts and are thought to be involved in numerous cellular events, including proliferation, differentiation, migration and neurite outgrowth. Gangliosides have also been shown to have neuroprotective actions and have been considered as candidates for the treatment of several neurodegenerative …
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Biomarkers of Optic Nerve Head Glial Cell Activation Following Biomechanical Insult
… irreversible apoptotic death of retinal ganglion cells, a unique optic nerve neuropathy resulting in loss of vision. Increased intra-ocular pressure is known to be a leading risk-factor for glaucoma, and lowering IOP is currently the only evidence based method for the clinical management of the …
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Effects of psychoactive trace minerals on glial cell development in vitro.
… interact with lithium to affect glioblastoma cell proliferation, function and viability in vitro. Two different glioblastoma cell lines (U87M0 and 132 1N1) were cultured in media containing different concentrations of either zinc or copper above and below the physiological range (0.02 to 10 …
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Identification of Connexins in Facilitating Neuron-Satellite Glial Cell Signaling in Trigeminal Ganglia
… between neurons and surrounding satellite glial cells via gap junctions in the trigeminal ganglion (TG). The goal of this study was to identify the gap junction proteins, or connexins (Cxs), in the ganglion in response to three different models of inflammation: acute, acute-sensitization, …
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The glial cell line-derived neurotrophic factor family in the olfactory system and brain
Glial cell line-derived neurotrophic factor (GDNF) family signaling has been implicated in development, survival and function of many different cell types, including neurons in the central nervous system. The family consists of four ligands [GDNF, neurturin (NTN), artemin and persephin] which bind …
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Pathological mechanisms involved in glial cell contribution in Parkinson's Disease - the perspective of senescence
Η κυτταρική γήρανση συνοδεύεται από αλλαγές όπως η μόνιμη διακοπή του κυτταρικού κύκλου, η αύξηση του μεγέθους του κυττάρου, η βλάβη στο DNA, η αντοχή στον κυτταρικό θάνατο και ένα χαρακτηριστικό εκκριτικό προφίλ που σχετίζεται με τη γήρανση, γνωστό ως SASP. Παρότι αποτελεί φυσιολογικό φαινόμενο …
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New roles of glial cell line-derived neurotrophic factor GDNF in motor and cholinergic functions
Glial cell line-derived neurotrophic factor (GDNF) is a protein that supports dopamine neurons and regulates multiple cellular processes in the brain and peripheral systems. Because of this, GDNF holds promising potential as a disease-modifying agent for several neurological disorders, including …
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Cytokine and neurotransmitter regulation of glial cell production of Il-6; indications for neurodegenerative disorders
… of SRIF on the production of IL-6 in rat C6 glial tumor cells. The release of IL-6 in the C6 cell conditioned media was quantified using the IL-6 dependent 7TD1 hybridoma bioassay; We decided to investigate GABA ability to inhibit the release of IL-6 by IL-1beta; To better understand the …
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Cloning of medaka glial cell-derived neurotrophic factor (GDNF) and its receptor GFR alpha 1
Glial cell line-derived neurotrophic factor (GDNF) signaling through its receptor GFRI?1 plays an important role in many biological processes including cell survival, proliferation and differentiation. The aim of this project was to isolate and characterize both Gdnf and GfrI?1 from the medaka fish …
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Lithium and brain plasticity - studies on glial cell changes and electroconvulsive treatment-induced amnesia in rats
… from patients with mood disorders have shown glial cell pathology. Electroconvulsive therapy (ECT) and pharmacological treatment with lithium have been used in the treatment of mood disorders for over 70 respectively 60 years, but the mechanisms behind their therapeutic effects remain elusive. …
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Studying the glial cell response to biomaterials and surface topography for improving the neural electrode interface
… after implantation due to the development of glial scar tissue (Polikov et al., 2006; Zhong and Bellamkonda, 2008). The long-term effect of chronically implanted electrodes is the formation of a glial scar made up of reactive astrocytes and the matrix proteins they generate (Polikov et al., …
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Towards a blood-based biomarker for remyelination: Glial cell death and associated byproducts in demyelinating disease
… remain limited. Recent studies have found that cell-free DNA (cfDNA) released from dying neurons and glia can be detected in the bloodstream using cell-specific methylation patterns. A better understanding of remyelination-associated glial cell turnover dynamics may aid in the discovery of …
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Hyperinflammatory Experimental Cerebral Malaria: Coagulation and Glial Cell Activation in Plasmodium chabaudi Infection of IL-10-deficient Mice
… severity of human malaria infection, very little cellular infiltrate is identified on autopsy in fatal cerebral malaria cases, suggesting a novel mechanism of local inflammation drives this syndrome. Vascular congestion is a prominent feature of all malaria parasites, although some species promote …
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Inflammation Promotes the Processing of Glial Cell-Line Derived Neurotrophic Factor by Matrix Metalloproteinase-9 in Intestinal Smooth Muscle Cells
… functions. Expression of the neurotrophin glial cell line-derived neurotrophic factor (GDNF) has been implicated in promoting postnatal regenerative processes in the ENS. It has been proposed that intestinal smooth muscle cells (ISMC) express GDNF as a precursor molecule that requires …
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Acetate Increases Brain Purine Metabolism And Glial Cell Culture Fatty Acid Content: Studies Investigating Glyceryl Triacetate's Therapeutic Mechanism Of Action
… in vitro BV2 microglia and primary astrocyte cell cultures. These experiments showed that in vitro acetate treatment had distinct cell-type specific effects on LPS-induced changes in adenosine metabolizing enzyme and receptor levels. These data suggest that GTA could be used to modulate …
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The Sandwich Synapse: Trans-glial Signaling Between Neuronal Somata in the Dorsal Root Ganglion
The dorsal root ganglion (DRG) contains the cell bodies of primary somatosensory neurons that form axonal connections for the transfer of sensory input from the peripheral nerve receptor to the spinal cord in the central nervous system. In general, DRG neuronal somata (NS) are each enveloped by …
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Microfluidic platforms to evaluate the effects of drugs on fertility and proteins on cancer progression – a focus on cisplatin, alpha-smooth muscle actin, and glial cell line-derived neurotrophic factor
… is necessary to get reliable information about cell responses and test drug efficacy and toxicity. Classical cell culture systems facilitate a wide range of clinical in vitro studies. These cell culture systems often consist of static and flat platforms that poorly mimic the conditions in living …
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