Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Glia cells"”.
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QUANTITATIVE ANALYSIS OF FLUORESCENT IMAGES OF GLIA CELLS USING DEEP NEURAL NETWORKS
… only neurons but also another diverse group of cells known as glia. In recent years, there has been a remarkable surge in interest among neuroscientists regarding glia cells due to their crucial role in brain function. Among the various glia cell types, astrocytes, the most abundant, actively …
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Effects of environmental complexity on neurogenesis in the hippocampal dentate gyrus
… (BrdU) injection, to label dividing cells, and were sacrificed either on P18, to evaluate cell proliferation or on P45, to evaluate cell survival and differentiation. Methods. Brain sections were processed for BrdU immunhistochemistry, to quantify the new born and surviving cells. The …
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Bionische Rekonstruktion definierter neuronaler Netze aus Insekten und Vertebraten unter Verwendung elektromagnetischer Felder
… Initially the isolation and positioning of the cells has been tried mechanically by using suction pipettes. Because this led to a reduction of viability and the chance of outgrowth declined, we decided to use dielectrophoresis (DEP) to position the neurons on the electrodes. This method is …
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Response of stretch-injured schwann cells
… matter axonal tracts, oligodendrocytes. Schwann cells can help take a first look into stretch injured glia cells from the Peripheral nervous system. In order to observe changes in Schwann Cells a stretch injury device is used to produce the effects of severe and moderate injuries. Schwann Cells …
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Quantitative Studies Defining the Cellular Composition of the Human Brain and Spinal Cord
… of the human brain, by claiming a much lower glia neuron ratio. This study also asserted that glia numbered less than 80 billion, a drastic reduction from the several trillion glia cells previously presumed to be present in human brains. To assess the validity of these claims, I first tested …
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Influence of Sex, Adolescence, and Aging on the Rat Basolateral Amygdala
… by significant increases in the number of glia cells and in the volume of the basolateral amygdala. No sex differences were found at any of the examined ages. The third study examined behavior of adolescent, adult, and aged male and female rats in performance of a BLA-dependent conditioned …
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Annotation-Free Deep Learning of Large-Scale Nuclear Segmentation and Spatial Neighborhood Analysis on Multiplexed Fluorescence Images
… proposed a spatial model to analyze the neuron-glia cells neighborhoods by cumulative influence of all neuron-glial pairs from the same circular surrounding area centered at the neuronal nuclei. A fast co-location analysis is applied to profile cell spatial neighborhoods in the healthy brain …
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UNDERSTANDING THE CELLULAR AND GENE-REGULATORY MECHANISMS UNDERLYING THE MESENCHYMAL TRANSITION OF EPENDYMOMA TUMOR CELLS USING OMICS APPROACHES
… cell lineages that resemble developmental radial glia cells and a tumor cell population with a mesenchymal gene expression profile that is associated with poor prognosis. However, little is known about the cellular and molecular mechanisms that enable the initiation, maintenance, and …
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Adapt, Survive or Die - Metabolic Imbalances and the Enteric Nervous System
… extensive interconnected network of neurons and glia cells, controlling intestinal motility, secretion and blood flow. It harbors a neurotransmitter variety and receptor diversity enabling interactions with neurons, immune, endocrine and intestinal cells as well as with luminal factors. Results …
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Cell-type specific contributions to Rett Syndrome : neuronal and astrocytic signaling and sensory processing
… in the brain, with recent evidence implicating glia cells in RTT pathophysiology. The focus of my thesis has been two-fold: exploring signaling mechanisms downstream of MeCP2 and the potential of IGF-1 as a therapeutic for RTT, and examining functional astrocyte sensory processing in healthy and …
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Single cell transcriptomic analysis of autism associated gene expression in human cerebral cortex development
… ASD risk genes are enriched in neural progenitor cells, excitatory neurons, interneurons and glia cells. Such enrichments were due to cell subtypes within these major cell types having significant differences in ASD risk gene expression. Cell-type based gene network analysis further demonstrated …
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Molecular mechanisms of floor plate formation and neural patterning in zebrafish
… cord is composed of billions of neurons and glia cells, which are formed in a highly coordinated manner during early neurogenesis. Specification of these cells at distinct positions along the dorsoventral (DV) axis of the developing spinal cord is controlled by a ventrally located signaling …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… bacteria in mice caused activation of microglia and dopaminergic neurodegeneration that was reflected as decreased locomotor activity. In the current study, it is hypothesized that IL-1 beta, a potent proinflammatory cytokine synthesized and released by glia cells, could be mediating the …
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Long-term effects of LPS and high-fat diet on dopaminergic neurodegeneration
… bacteria in mice caused activation of microglia and dopaminergic neurodegeneration that was reflected as decreased locomotor activity. In the current study, it is hypothesized that IL-1 beta, a potent proinflammatory cytokine synthesized and released by glia cells, could be mediating the …
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Molekulargenetische und funktionelle Untersuchungen zu autosomal-rezessiv erblichen Neuropathien
… Kiaa1985 is exclusively expressed in Schwann cells, the myelinating glia cells of the peripheral nervous system. The pattern of expression correlates with the affected tissue in patients with CMT4C. Investigations of the subcellular localization of KIAA1985 revealed that KIAA1985 can be bound …