Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Gli3"”.
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Gli3 regulates the proliferation and differentiation of progenitors in the developing neocortex
… factors. The zinc-finger transcription factor Gli3 plays established roles in regulating the development of the dorsal telencephalon. Through the evaluation of a number of mutants, Gli3 has been shown to function in patterning, the production and fate of cortical neurons, lamination, and axon …
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Dissecting the Role of Hedgehog Pathway in Murine Gonadal Development
… the third question on the possible role of GLI3 (as a transcriptional repressor) to silence the Hh pathway in the fetal ovary, which expresses other mammalian Hh genes, such as Shh. The repressor form of GLI3 was expressed in the fetal ovary, and null mutation of Gli3 led to Hh activation …
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Genomic Regulation of the Shox2 Gene during Mouse Limb Development
… Indeed, we found several previously determined GLI3 binding regions (Vokes et al., 2008) to overlap with a subset of characterized Shox2 limb enhancers and with the Shox2 gene, suggesting that hedgehog signalling may be a regulatory input for this gene’s expression. Genetic examination of …
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Whole-exome sequencing variant prioritization in individuals with tense and agreement marking deficit— a clinical marker of specific language impairment
… likely contributing to overall language ability (GLI3 and FLNB). Importantly, the results show selective prioritization of genes associated with low performance on the TEGI and underline the importance of family-based genetic study. Evidence at the family-level, from bioinformatic prediction …
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The role of Hedgehog signalling in T cell effector function
… Hh pathway acts transcriptionally through Gli3 and metabolically through AMPK to control Th polarisation in vitro and in vivo. Taken together, this work explores the roles of distinct modes of Hh signalling in the adaptive immune system and may guide future therapeutic approaches to …
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Studies of exon scrambling and mutually exclusive alternative splicing
… events. Exon scrambling of transcripts from the GLI3 gene, which encodes a transcription factor involved in hedgehog signaling, was also conserved in mouse. Specific gene features, including the presence of long flanking introns were found to be associated with exon scrambling. Chapter 2 deals …
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A functional and therapeutic investigation of ciliopathy proteins and ciliopathies
… processing of the transcription factor Gli3. I modelled ten different ciliopathy genes in the zebrafish and identified specific ciliary phenotypes, such as laterality randomisation, otic vesicle anomalies, and kidney cysts. Administration of two drugs, Rapamycin and Roscovitine, were …
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THE EVOLUTION OF THE MODERN CONDITION THROUGH THE LENS OF NEURODEVELOPMENT DIVERSITY: INSIGHTS FROM A PARADIGMATIC REWIRING OF GENE REGULATION
… radial glia, and predicted a higher affinity of GLI3 for the modern allele in an enhancer linked to KLF6, consistent with its role in balancing proliferative and differentiative radial-glia divisions. Leveraging a prioritisation pipeline that integrates prior knowledge with deep learning-based …