Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Gli2"”.
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Tumor-like growth of mouse embryonic stem cells
… ESCs, surprisingly I found that the oncogene Gli2, a downstream target of the growth factor Sonic hedgehog (Shh), was expressed in undifferentiated mouse ESCs, which was further validated by semi-quantitative RT-PCR and immunofluorescent microscopy. It is well-known that the Gli2 protein is …
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Identifying Oncogenic Drivers of Poor Outcome in Triple Negative Breast Cancer
… this study we identified that TGFβ2, YWHAZ and GLI2 are upregulated in poor outcome TNBC cell lines work together with FOXC1 to subvert the growth control effects of TGFβ2-pSMAD2/3 signalling towards transcriptional activation of EMT and metastasis driving genes. Furthermore, we identified this …
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Dissecting the Role of Hedgehog Pathway in Murine Gonadal Development
… second question on the essential role of GLI and GLI2, as Hh transcriptional activators, to induce FLC development. My data showed that both GLI1 and GLI2 were modulators of Hh to establish FLCs. In chapter V, I addressed the third question on the possible role of GLI3 (as a transcriptional …
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14-3-3 Zeta Overexpression Serves As A Novel Molecular Switch Turning Tgf-Beta From Tumor Suppressor to Tumor Promoter
… bone metastatic colonization through stabilizing Gli2, which is an important co-transcriptional factor for p-smad2 to activate PTHrP expression and bone osteolytic effect. Taken together, we reveal a novel mechanism that 14-3-3ζ dictates the tumor suppressor or metastases promoter activities of …
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Ο ρόλος του σηματοδοτικού μονοπατιού Sonic Hedgehog στον καρκίνο του πνεύμονα
… της έκφρασης των μορίων Shh, Ptch1, Smo, Gli1, Gli2 και FoxM1. Τα αποτελέσματα αποκάλυψαν μια έντονη έκφραση των μορίων του μονοπατιού και αυξημένα ποσοστά ενεργοποίησής του. Επίσης βρέθηκε στατιστικά σημαντική συσχέτιση με τα πλακώδη καρκινώματα και με τα χαμηλού grade καρκινώματα. Ανάλογη …
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The transcriptional regulation of skeletal muscle progenitor cell fate
… Foxc1 during differentiation. Loss of functional Gli2 and Meox1 led to the downregulation of Foxc1/2, while misexpression of Gli2 upregulated the expression of these two genes. These studies have helped us define the pathways that regulate Foxc1/2 expression, and more specifically that functional …
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Uncovering Signalling Pathways Mediating Gastrointestinal Morphogenesis and Tumorigenesis
… the Hedgehog targetome in vivo, we revealed GLI2 transcriptional activation of atypical cadherin and planar cell polarity genes in the mesenchyme. Moreover, by using a combination of mouse genetics, live imaging and 3D-culture based approaches, I have demonstrated a requirement for planar …
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Funktionsanalyse des Irx1-Gens
… untersucht. Die Analyse der Gli1- und Gli2-Mausmutanten konnte eine Interaktion mit Irx1 zeigen, was auf eine konservierte Regulatorfunktion hindeutet. Die in vitro-Analyse eines potentiellen Zielgens von Irx1 ergab, daß keine Aktivierung des Mash1-Promotors vorliegt. Die Regulation …