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Showing 1 to 11 of 11 for “"GlcN"”.
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Solution and solid phase synthesis of N,N'-diacetyl chitotetraoses
… The β-(1→4) linked N-acetylglucosamine (GlcNAc) moiety is a frequently occurring structural unit in various naturally and biologically important oligosaccharides and related conjugates. Chitin which is the most abundant polymer of GlcNAc is widely distributed in nature whereas the related …
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Subcutaneous and oral delivery of insulin
… from degradation. The effect of glucosamine HCl (GlcN⋅HCl) on the bioactivity of insulin, administered via subcutaneous (SC) and oral routes, in rats was also investigated. The oral insulin delivery system (IC-RM) was prepared by solubilizing insulin-chitosan (13 kDa) polyelectrolyte complex …
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Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
… and separation of glucosamine-1-phosphate (GlcN-1-P) and glucosamine-6-phosphate (GlcN-6-P) on a reverse-phase column is not feasible due to their high polarity. The second part of this study tested and demonstrated several derivatization procedures to improve the retention of GlcN-1-P and …
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Synthesis of Hetero-chitooligosaccharides
… 2-acetamido-2-deoxy-β-D-glucopyranose (GlcNAc) and/or 2-amino-2-deoxy-β-D-glucopyranose (GlcN). They are of interest due to their remarkable biological properties including antibacterial, antitumor, antifungal and elicitor activities. They can be obtained from the aminoglucan chitosan by …
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Synthetic studies of heparan derivatives: Glycosyl couplings and post-glycosylative modifications
… can be constructed from readily accessible D-GlcN and D-GlcA derivatives, but the inclusion of L-IdoA is less straightforward. To address this, our laboratory has developed alternative synthetic strategies for HS-like oligosaccharides to incorporate either D-GlcA or L-IdoA in a synthetically …
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Identification of native co-factors of MshB and MCA from Mycobacterium species
… (MCA). MshB catalyzes the deacetylation of GlcNAc-Ins to form GlcN-Ins and acetate. Mycothiol S-conjugate amidase (MCA) cleaves the amide bond of mycothiol S-conjugates of various drugs and toxins. The identification of the native co-factor is critical for the design of potent and effective …
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Enzymatic Characterization of N-Acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside Deacetylase (MshB)
… inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside (GlcNAc-Ins) to 1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside (GlcN-Ins). In this dissertation, we present detailed functional analysis of MshB. Our work has shown that MshB is activated by divalent metal ions that can switch between Zn2+ …
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Fluorous- Phase Synthesis of Heparan Sulfate Disaccharides & Low-Molecular Weight Additives for Enhancing the Performance of Lithium-Ion Batteries.
… of glucuronic acid (GlcA) and glucosamine (GlcN) could be prepared with a variable set of sulfonated substituents. The fluorous tag was retained on the final product to enable their non- covalent adhesion onto perfluoroalkyl-functionalized glass slides in microarray format, for biological …
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Substrate binding to MshB, a zinc-dependent deacetylase in the mycothiol biosynthetic pathway of Mycobacterium tuberculosis
… amido-2-deoxy-α-D-glucopyranosyl)-D-myo-inositol (GlcNAcIns), via cleavage of an amide bond, to 1-O-(2-amino-2-deoxy-α-D-glucopyranosyl)-D-myoinositol (GlcN-Ins) and acetate. MshB is a homolog of another zinc-dependent amidase, mycothiol S-conjugate amidase (Mca), which recycles GlcNAc-Ins by …
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CHARACTERIZATION OF THE INTERACTION BETWEEN HEPARAN SULFATE AND THE SPIKE (S) PROTEIN OF THE LATEST SARS-COV-2 VARIANTS
… or L-iduronic) 1→4 linked to a glucosamine (GlcN). The glucosamine residues can be mono- or polysulfated at the N-, 6-O, and rarely at the 3-O positions, while the uronic acids can be sulfated at the 2-O position. Furthermore, HS displays heterogeneity in chain length and block composition, …
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Mechanisms of polyphosphate degradation
The goal of my research has been to investigate the mechanisms by which inorganic polyphosphate (polyP) is degraded in vivo. PolyP is a linear chain of phosphate moieties linked through high-energy phosphoanhydride bonds and can range in size from three-phosphates-long to thousands. Naturally, …