Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Gingipain"”.
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Role of VimF in Gingipain Maturation in Porphyromonas gingivalis
Gingipain activity in Porphyromonas gingivalis, the major etiological agent in adult periodontitis, is post-translationally regulated by unique Vim proteins including VimF, a putative glycosyltransferase. To ascertain the VimF mediated phenotype we first inactivated the vimF gene in P. gingivalis …
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Synergism of Gingipains in Endothelial Cell Adhesion Disruption and Apoptosis
… the periodontal pocket and the high levels of gingipain activity detected in gingival crevicular fluid could implicate a role for gingipains in the destruction of the highly vascular periodontal tissue. To explore the effects of these proteases on endothelial cells, we exposed bovine coronary …
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Mechanisms of Virulence Regulation in Porphyromonas gingivalis W83
… virulence factors of <em>P. gingivalis</em>, the gingipains, are responsible for pathogenesis including degradation of complement and immunoglobulin, inactivation of cytokines and their receptors, aggregation of platelets, attenuation of neutrophil antibacterial activities, and increase in …
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Antibacterial Activities of Cannabidiol Against Two Major Oral Pathogens
… provided an inhibitory effect on lysine-specific gingipain. The results of these studies demonstrate that CBD has antibacterial activities against S. mutans and P. gingivalis growth and virulence factors related to caries and periodontal diseases, respectively.
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Role of VimA in Cell Surface Biogenesis in Porphyromonas gingivalis
… to play a significant role in the biogenesis of gingipains (trypsin-like cysteine proteases). The <em>vimA </em>has also been demonstrated to play a role in hemolysis, hemagglutination, autoaggregation, posttranslational protein modification, and LPS biogenesis. Though significant progress has …