Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Ghrelin receptor"”.
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An Investigation into the pharmacology of the ghrelin receptor
The ghrelin receptor (GRLN-R) was cloned in 1996 after the discovery that a series of synthetic growth hormone-releasing compounds (the growth hormone secretagogues) acted through a receptor distinct from the growth hormone-releasing hormone receptor. In 1999 the endogenous ligand of the receptor, …
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The structure and function of the human ghrelin receptor
The peptide hormone, ghrelin, exerts its physiological effects through a G-protein-coupled receptor called the ghrelin-R. The ghrelin-R displays a high degree of constitutive activity, signalling through the inositol phosphate pathway in the absence of bound agonist. TMs III and VI have been …
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Neurobiologically-motivated treatments for post-traumatic stress disorder in an animal model
… fear learning and increases plasma acylated ghrelin. This effect is independent of the hypothalamus-pituitary-adrenal (HPA) axis since it was unaffected by prior bilateral adrenalectomy. Chronic exposure to a ghrelin receptor agonist, without stress, enhanced associational fear learning …
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Ghrelin: The Hunger Hormone that Isn't
Ghrelin is a 28-amino acid acylated peptide hormone secreted by endocrine cells in the stomach. It was first identified in 1999 and shortly thereafter shown to stimulate appetite when injected into rodents and humans. While ghrelin knockout mice have failed to show a decrease in appetite or …
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Investigating the Enteroendocrine - Brain Axis: Ghrelin Cell and ECL Cell Physiology and Ghrelin Action on Mood and Complex Eating
… through which the orexigenic peptide hormone ghrelin act to regulate homeostatic feeding is fairly well documented. However, less understood are the mechanisms and brain regions that mediate ghrelin's effects on mood and complex eating behaviors. At the cellular level, little is known about …
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Endocannabinoid regulation of gastric vagal afferent signalling
… to increased meal size. Further, transient receptor potential vanilloid 1 (TRPV1) knockout mice also show decreased GVA tension receptor sensitivity. Endocannabinoids (ECs) regulate appetite via cannabinoid 1 (CB1) receptors and are also endogenous ligands for TRPV1. The CB1 receptor and …
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Decoding the interplay between the microbiota-gut-brain axis and the hypothalamic regulation of eating behaviour
… able to modulate the hypothalamic expression of ghrelin receptor and glucagon-like peptide 1, genes involved in appetite regulation (Chapter 3). Additionally, we showed that metabolite-containing cell-free bacterial supernatants, as well as the microbiota-derived metabolite lactate, were able to …
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Quality of life, Biomarkers, and Involvement of Ghrelin in Women with Breast Cancer
… treatment for the cancer and the role of ghrelin hormone in BC and depression at a tissue level and at serum level. In order to examine QOL with its all dimensions among women with BC, an epidemiological case-control study was conducted recruiting a sample of 300 women, 155 women with BC …
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A Survey of Stapling Methods to Increase the Affinity, Activity and Stability of Ghrelin Analogues
The growth hormone secretagogue receptor (GHSR) is a G protein-coupled receptor which regulates various important physiological and pathophysiological processes in the body. Ghrelin is the primary high affinity endogenous ligand for GHSR and has limited secondary structure in solution, which makes …