Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Germinal centre response"”.
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Age-associated Changes in the Germinal Centre Response Upon Vaccination
SUMMARY Title: Age-associated Changes in the Germinal Centre Response upon Vaccination Name: Alyssa Silva Cayetano Vaccination efficacy is reduced in older individuals due to diminished immune system function with advancing age. The germinal centre (GC) response plays a crucial role in generating …
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Environmental stimuli shape adaptive immunity by enhancing T helper cell differentiation and the germinal centre response
… inflammatory signalling with the ER stress response pathway. This response is triggered by a variety of environmental stresses such as low nutrient availability, hypoxia and mechanical stress. I found that the ER stress response acts as a potent driver of T helper 17 (Th17) cell …
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Adaptive Immune Responses to Vaccination Against SARS-CoV-2 in Individuals with Immune Dysregulation
… novel mRNA technology to produce an immune response against the viral spike protein. The efficacy of these vaccines was key to control the pandemic and beyond this, vital for the protection of individuals at high risk from disease. The pace of the expeditious approval and subsequent …
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A Characterisation and Understanding of the Germinal Centre B Cell Response to Atherosclerosis in Mice using Lineage Tracing
… neo-epitopes that drive inflammatory immune responses underlying the pathogenesis of atherosclerosis. The germinal centre is found within secondary lymphoid organs and is responsible for the production of high affinity antibody-producing plasma cells and long-lived memory B cells against …
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Studying the B and plasma cell responses to the immune checkpoint blockade treatment of cancer
… their effects on anti-tumour B and plasma cell responses, which are now regarded as important components of the adaptive immune response to cancer. Additionally, the utility of ICB therapies is limited by the immune-related adverse events (IrAEs) they induce – toxic autoimmune conditions that …
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Age-dependent changes in the mouse lymph node and implications for immune responses
… in aged individuals. The first step of an immune response in the lymph node starts with the entry of antigen to the tissue. Antigens enter the lymph node via lymphatic vessels either freely or carried by dendritic cells. I hypothesised that antigen access to the lymph node is impaired in ageing. …
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Follicular Regulatory T cell migration and differentiation
The germinal centre (GC) response is critical for generating highly effective humoral immune responses and immunological memory that forms the basis of successful immunisation. Control of the output of the GC response requires Follicular regulatory T (Tfr) cells, a subset of Foxp3+ Treg cells …