Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Germinal center B cells"”.
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Transcription factor regulation of T helper subset function
… protects the body from foreign organisms. T cells and B cells are integral components of the ability of the immune system to generate focused immune responses. The development of specialized subsets of T helper cells is governed by transcription factors. Previous work demonstrated a …
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HOST RESPONSE TO PRIMARY AND SECONDARY CORONAVIRUS EXPOSURES AND POTENTIAL GERMINAL CENTER MECHANISMS ASSOCIATED WITH PROTECTION DURING RE-EXPOSURE
… limited protection against SARS-CoV-2, distinct germinal center response signatures were observed depending on the antigenic similarity between primary and secondary inoculations. To gain more insight into the germinal center response, my third objective examined memory establishment and recall …
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Combined Inhibition of SREBP and m-TORC1 Signaling Synergistically Inhibits the Proliferation of B Cell Lymphoma
… B cell activation and the proliferation of germinal center B cells. It is unclear whether this pathway can be targeted to effectively treat B cell lymphoma. We discovered that inhibiting SREBP signaling or its downstream target HMG-CoA reductase (HMGCR) using Fatostatin or Simvastatin …
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Molecular defects in B lymphocytes from patients with CVID- syndrome
… experiments with CVID peripheral blood B cells (CD19+) showed, that CVID B cells could secrete IgM, but no or only few IgG. Transplantation of human peripheral blood lymphocytes of two CVID patients into the spleen of immunodeficient mice showed that the functional B cell integrity was …
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Signaling pathways and novel therapeutic strategies for the treatment of murine chronic graft versus host disease
… for testing of novel therapeutic agents. Donor T-cells, responsible for the initiation disease, require specific signaling pathways and changes in their metabolic profile to sustain their survival, proliferation and differentiation. In cGVHD, activated donor CD4+ T-cells differentiate into …
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Programmed death-1 regulates islet-specific lymphocytes in type 1 diabetes
… is highly expressed on chronically stimulated T cells, such as those specific for persistent viral or tumor antigens. PD-1 pathway blockade revolutionized cancer therapy in recent years. While response rates are higher than with chemotherapy, not all patients respond, and some develop …
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Genome-Wide Characterization of the Effects of Nucleic Acid Modifying Enzymes: Cytidine Deaminases and DNA Methylation
… processes of immunoglobulin diversification in germinal center B cells: somatic hypermutation (SHM), in which mutations are introduced into immunoglobulin (Ig) genes, and class-switch recombination (CSR), in which genomic constant regions are recombined to encode antibodies of different …
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Early Growth Response Protein 2 (EGR2) regulation of B cell differentiation in lupus-prone mice
… treatment. It involves abnormal activation of B cells, which produce pathogenic autoantibodies that contribute to inflammation and tissue damage in multiple organs. Therapeutic depletion of B cells in human lupus patients had mixed success due to the complex heterogeneity of B cell subsets, …