Global ETD Search
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Showing 1 to 20 of 64 for “"Germinal center"”.
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Recall Germinal Center and Antibody Responses
… clonal expansion and affinity maturation in germinal centers(GCs) during the primary response. Upon antigen re-encounter ("boosting"), MBCs, aided by enhanced help from memory T cells, efficiently differentiate into antibody-secreting plasma cells. At the same time, boosting induces recall …
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Replaying Life's Tape With Intraclonal Germinal Center Evolution
<p>Because high-affinity antibodies produced by germinal centers (GCs) are critical in protecting against the ever-increasing array of pathogens, understanding how GC response allows our immune system to recognize a variety of pathogens and develop specific and effective immunity against each …
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Selection Dynamics in the Germinal Center During Antibody Affinity Maturation
… humoral immunity. This process takes place in germinal centers (GCs), which are microanatomical structures composed of antigen-specific B lymphocytes that form in secondary lymphoid organs upon infection or immunization. High affinity B cells are selectively expanded in the GC by iterative …
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Investigating the Effect of Antibody-Mediated Feedback on Ongoing Germinal Center Responses
… requires the participation of B cells in the germinal center (GC) response. It is well-established that pre-existing antibodies can influence the outcome of future humoral responses; however, whether antibody from an ongoing response can feedback onto contemporaneous GCs to influence B cell …
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Dysregulated TFH cell and germinal center activation in mice with severe Orientia tsutsugamushi infection
Scrub typhus is a severely understudied tropical disease caused by Orientia tsutsugamushi. It is endemic in, but not limited to, the Asia-Pacific region, with about one million cases reported every year. Its high case fatality rates and impact during WWII and the Vietnam War justify vaccine …
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Regulation of the germinal center reaction by T helper cells and T regulatory cells
Germinal Centers (GCs) are transient lymphoid structures that arise in lymphoid organs in response to T cell-dependent antigen. Within the GC, follicular T helper (TFH) cells promote GC B cell differentiation and in turn the proper antibody production to protect us from invading pathogens. We …
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Interplay between Extra-Germinal Center expansion of memory B cells and affinity maturation during the humoral recall response
… undergo a Darwinian evolutionary process in the Germinal Center (GC) to generate tailored memory and antibodies. Memory B cells generated in the GC can be recalled in extra-germinal center processes (EGC) to create a large, rapid antibody response. During the recall response, new GCs also form. …
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HOST RESPONSE TO PRIMARY AND SECONDARY CORONAVIRUS EXPOSURES AND POTENTIAL GERMINAL CENTER MECHANISMS ASSOCIATED WITH PROTECTION DURING RE-EXPOSURE
… limited protection against SARS-CoV-2, distinct germinal center response signatures were observed depending on the antigenic similarity between primary and secondary inoculations. To gain more insight into the germinal center response, my third objective examined memory establishment and recall …
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The role of Fyn and B-cell expressed ADAM10 in early B cell development, germinal center formation and terminal B cell differentiation
… affected, consistent with defects in germinal center (GC) reactions. Moreover, changes in lymphoid architecture were also observed. Consistent with these findings, follicular dendritic cell (FDC)-reticula was undetectable following immunization. On the other hand, when ADAM10 was …
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Regulation of Autoimmune Germinal Center Reaction By Tfh Cells and Application of Tfr-Like Cells For The Treatment of Autoimmune B Cell Responses
… Treg cells expressing CXCR5 can migrate into the germinal center (GC) zone where they specifically suppress GC reactions <em>in vivo</em>, presumably by directly suppressing B cells and/or Tfh cells. These CXCR5<sup>+</sup> Foxp3<sup>+</sup> Treg cells are termed as follicular regulatory T (Tfr) …
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STEPWISE DIFFERENTIATION OF IL21-PRODUCING FOLLICULAR HELPER T CELLS REVEALS DISTINCT DEVELOPMENTAL AND FUNCTIONAL STATES
… helper T (Tfh) cells with B cells within the germinal center of secondary lymphoid organs is essential for the formation of high affinity antibodies, a key effector mechanism of adaptive immunity. Interleukin (IL)-21 is a proinflammatory cytokine produced by Tfh cells, however the signals that …
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Transcription factor regulation of T helper subset function
… of T follicular helper (Tfh) cells and increased germinal center responses. This correlated with increased expression of the cytokine IL-21 and the surface protein CD40L in T cells that lacked PU.1 expression and resulted in increased numbers of germinal center B cells and antigen-specific …
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Integrative Genomics Reveals a Role for GNA13 in Lymphomagenesis
… in GNA13 can be oncogenic in the context of germinal center B cell biology. Using in vitro techniques including liquid chromatography-mass spectrometry and knockdown and overexpression of genes in B cell lymphoma cell lines, I determine protein binding partners and downstream effectors of …
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Mathematical Models of Immune Responses to Infectious Diseases
… i) A study of HIV and HPV co-infection, ii) A germinal center dynamics model, iii) A study of monoclonal antibody therapy. We predict that the condition leading to HPV persistence during HIV/HPV co-infection is the permissive immune environment created by HIV, rather than the direct HIV/HPV …
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Programmed death-1 regulates islet-specific lymphocytes in type 1 diabetes
… from B cell:CD4+ T cell interactions in the germinal center of the lymph node. The dynamics and regulation of the germinal center in spontaneous autoimmunity and after PD-1 blockade are not well understood, primarily due to an inability to track self-specific lymphocytes. To bridge this …
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Visualizing Dendritic Cells In Vivo
… We further examined the in vivo dynamics of germinal center reactions, and observed that germinal centers are dynamic structures, with nearly all GC B cells remaining motile and restricted to the germinal center, migrating bidirectionally between dark and light zones. Follicular B cells …
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The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring
… changes in lymphocyte populations and early germinal center formation in naive offspring. Maternal Nb infection does not interfere with control of STm in offspring in BALB/c mice, but may interfere with control of STm in C57BL/6 mice.
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The Role of Activation-Induced Cytidine Deaminase in Antibody Diversification and B Cell Malignancies
… translocations can be detected in vivo in germinal center (GC) B cells of immunized mice, and that these cells also express Rae-1. However, these calls are found in same frequencies in NK + and NK- mice, implying that NK cells may be actively excluded from the GC. In addition, my data …
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Signaling pathways and novel therapeutic strategies for the treatment of murine chronic graft versus host disease
… cell subset that provide necessary signaling to germinal center B cells to promote their differentiation into antibody-producing plasma cells. Immunoglobulin deposition along with abnormal tissue repair activates pro-fibrotic pathways, leading to collagen buildup in target organs in cGVHD. In …
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