Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Germinal Centres"”.
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Mechanisms Underpinning Functional Resident Humoral Lung Immunity
… key differences between classic and ectopic germinal centres which may inform how we can improve medical interventions to enhance humoral protection against autoimmunity and infectious disease. B cells undergo selection in secondary lymphoid tissue germinal centres which can improve the way …
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Dissecting the role of RNA helicase DDX3X in mRNA translation and B-cell function during immune responses
During B-cell immune responses, germinal centre structures are the primary sites of antibody affinity maturation and a common site of B-cell lymphomagenesis. Mutations in DEAD-box helicase 3X (DDX3X) have previously been found in B-cell lymphomas driven by the transcription factor MYC. Reduced …
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The role of DEAD-box helicase 1 in humoral immune responses
… on characterising the formation and function of Germinal centres (GC); microanatomical structures where affinity enhancement and B-cell clonal expansion occurs, following T-cell dependent immunisation. We discovered that GC-specific ablation of DDX1 resulted in reduced GC size with a reduction in …
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Signals for B cell activation in antibody response
Germinal centres (GCs) are the sites where V-gene hypermutation and B cell selection are taking place. Testing specificity and affinity of GC B cell receptor by interaction with antigen on follicular dendritic cells (FDCs) may be an important selection process to select high affinity B cell clone. …
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Follicular Regulatory T cell migration and differentiation
The germinal centre (GC) response is critical for generating highly effective humoral immune responses and immunological memory that forms the basis of successful immunisation. Control of the output of the GC response requires Follicular regulatory T (Tfr) cells, a subset of Foxp3+ Treg cells …
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Understanding the Effects of Ageing on B cells Response to Vaccination
… favoured at the expense of B cells entering the germinal centre (GC) during the early stages of GC formation, compared to those from young donors. Nevertheless, by the peak of the GC response, GC B cells derived from B cells of aged mice had expanded to the same extent as those from the younger …
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A novel genomics and bioinformatics approach to assess immunoglobulin and T cell receptor rearrangements and somatic hypermutation in lymphoproliferative disorders
… cell development and is primarily restricted to germinal centres (GC). SHM has therefore been reported in lymphoproliferative disorders (LPDs) from GC origin. Strong prognostic links and clinical indications based on SHM status have been described in chronic lymphocytic leukaemia (CLL) were …
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A Characterisation and Understanding of the Germinal Centre B Cell Response to Atherosclerosis in Mice using Lineage Tracing
… the pathogenesis of atherosclerosis. The germinal centre is found within secondary lymphoid organs and is responsible for the production of high affinity antibody-producing plasma cells and long-lived memory B cells against antigens such as epitopes of oxidised LDL. Class-switched plasma …