Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"Germinal Centers"”.
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B Cell Receptor Signalng in Germinal Centers
<p>Germinal centers (GC) are sites of B cell clonal expansion, diversification, and antibody affinity selection. This process is limited and directed by T follicular helper cells that provide helper signals to B cells that endocytose, process, and present cognate antigens in proportion to receptor …
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Recording Cellular Interactions in Germinal Centers and Beyond
… and occurs within specialized structures called germinal centers (GCs). While it is well-established that T-B interactions are essential for the formation and maintenance of GCs, the precise role of T cell help as the primary driver of positive selection remains debated. In this work, I introduce …
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Plasmacytoid Dendritic Cell-Mediated Humoral Autoimmunity
… that, when IgM autoantibodies were induced, germinal centers were inhibited whereas immature B cells were activated and expanded. Such interesting observation suggested that humoral autoimmunity may arise from B cells outside germinal centers. While pDCs were involved in the overt activation …
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The Effect Of Maternal Antibodies On Anti-Viral Immunity In Infant Mice
… inhibition by prolonged establishment of germinal centers. mRNA-LNP vaccination offers a promising means of eliciting protective immune responses in infants in the presence of maternal antibodies. These results have important implications for the design of vaccines for use in mothers and …
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Visualizing Dendritic Cells In Vivo
… We further examined the in vivo dynamics of germinal center reactions, and observed that germinal centers are dynamic structures, with nearly all GC B cells remaining motile and restricted to the germinal center, migrating bidirectionally between dark and light zones. Follicular B cells …
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Selection Dynamics in the Germinal Center During Antibody Affinity Maturation
… humoral immunity. This process takes place in germinal centers (GCs), which are microanatomical structures composed of antigen-specific B lymphocytes that form in secondary lymphoid organs upon infection or immunization. High affinity B cells are selectively expanded in the GC by iterative …
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TFR Cells Suppress Gut Commensal-Specific IgA Via IL-10
… IgA Abs are produced through T cell help in the germinal centers of gut-associated lymphoid tissues. Through this pathway, T follicular helper (TFH) cells drive affinity maturation by selecting B cells that produce high-affinity Abs, including IgA. Concurrently, T follicular regulatory (TFR) …
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Computational Study of Vaccination Strategies to Change B Cell Immunodominance
… engagement and T cell-mediated selection within germinal centers. The second project addresses the enhanced efficacy of a third dose of SARS-CoV-2 vaccines against the Omicron variant. Through computational models and human vaccination data, we find that a third dose significantly boosts …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
… we identified a Tfh subset localized outside germinal centers (GCs) in human tonsils. This subset expressed low-levels of CXCR5 and ICOS (CXCR5loICOSlo) and helped naïve B cells more efficiently than GC-Tfh cells through high IL-21 production. Notably, CXCR5loICOSlo Tfh cells lacked the …
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The role of TLR3- and MyD88-dependent signaling in the development of anti-West Nile virus adaptive immune responses induced by a vaccine candidate, RepliVAX WN.
… CD8+ T cells, B cell activation, cellularity of germinal centers, and the generation of long-lived plasma cells (LLPCs) and memory B cells (MBCs). In contrast, TLR3 deficiency had more impact on the functional pattern of T cell responses, memory T cell generation and reactivation, the development …
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Regulation of the germinal center reaction by T helper cells and T regulatory cells
Germinal Centers (GCs) are transient lymphoid structures that arise in lymphoid organs in response to T cell-dependent antigen. Within the GC, follicular T helper (TFH) cells promote GC B cell differentiation and in turn the proper antibody production to protect us from invading pathogens. We …
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Determination of functionally distinct subsets of human tonsillar and blood T follicular helper (Tfh) cells.
… we identified a Tfh subset localized outside germinal centers (GCs) in human tonsils. This subset expressed low-levels of CXCR5 and ICOS (CXCR5loICOSlo) and helped naïve B cells more efficiently than GC-Tfh cells through high IL-21 production. Notably, CXCR5loICOSlo Tfh cells lacked the …
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Replaying Life's Tape With Intraclonal Germinal Center Evolution
<p>Because high-affinity antibodies produced by germinal centers (GCs) are critical in protecting against the ever-increasing array of pathogens, understanding how GC response allows our immune system to recognize a variety of pathogens and develop specific and effective immunity against each …
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Recall Germinal Center and Antibody Responses
… clonal expansion and affinity maturation in germinal centers(GCs) during the primary response. Upon antigen re-encounter ("boosting"), MBCs, aided by enhanced help from memory T cells, efficiently differentiate into antibody-secreting plasma cells. At the same time, boosting induces recall …
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The role of Fyn and B-cell expressed ADAM10 in early B cell development, germinal center formation and terminal B cell differentiation
… affected, consistent with defects in germinal center (GC) reactions. Moreover, changes in lymphoid architecture were also observed. Consistent with these findings, follicular dendritic cell (FDC)-reticula was undetectable following immunization. On the other hand, when ADAM10 was …
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Analysis of Adenosine 2a Receptors During the Immune Recognition of Foreign and Self-Antigens
… by diverting helper T cells away from a germinal center follicular helper T cells (GC-Tfh) linage that promotes the survival, differentiation, isotype class-switching, and affinity maturation of B cells. Although GC-Tfh cells are beneficial during the clearance of certain pathogens, they …
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B Cell Activation: The Regulation by T Cells and the Induction of the Protein Tyrosine Kinase SYK
… functionally, these B lymphoblasts resembled the germinal center B cell.</p>
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Engineering kinetics of immunotherapies and vaccines
… dosing of immunogens can trigger long-lived germinal center responses, promote somatic hypermutation, and increase neutralizing antibody breadth. As one form of extended dosing, escalating-dosing (ED) immunization, where a given dose of antigen/adjuvant is administered as 7 injections of …
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New Mediators and Novel Mechanisms in Allergic Airway Inflammation
… S100A7 protein was detected in the epithelium, germinal centers and T cell zones. S100A7 mRNA expression levels among allergic individuals were generally lower than in healthy control subjects. A similar picture was seen in the nose when patients sampled outside pollen season were compared to …
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Interrogation and Manipulation of the IGG FC Glycan
… residue, Asn 297, exhibit deficiencies in germinal center (GC) responses. In this model, B cells with an aglycosylated BCR participate less frequently in the GC reaction, bind antigen less avidly, and show signaling deficits downstream of BCR engagement. Development of an aglycosylated …
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