Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Germ cell tumour"”.
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MicroRNAs and Extracellular Vesicles: investigating their role in the Testicular Germ Cell Tumour Microenvironment.
Testicular germ cell tumours (TGCT) are the most common malignancy in young adult men and are characterised by their broad heterogeneity in terms of differentiation stage, histological presentation and capacity for progression. In addition, the tumour microenvironment (TME) of these tumours varies …
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Targeting oncogenic microRNAs in malignant germ cell tumours.
Malignant germ cell tumours (mGCTs) are a heterogenous group of tumours that occur primarily in the testes and ovaries but also in other anatomical sites, and affect people of all ages. It was established by the Coleman group through microRNA profiling in 2010 that all mGCTs, regardless of tumour …
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Downregulation of miRNA expression in malignant germ cell tumours: mechanism and functional significance
Germ cell tumours (GCTs) are clinically and pathologically heterogeneous neoplasms that arise at gonadal (testicular/ovarian) and extra-gonadal sites. The chemotherapy burden for patients with malignant germ cell tumours (mGCTs) that require treatment results in substantial longterm side-effects, …
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CLINICAL VALIDATION OF 371 MICRO-RNA USE IN SMALL TESTICULAR MASSES AND IN STAGE IIA AND IIB<3CM TESTICULAR GERM CELL TUMORS
Background and Objectives Testicular Germ-cell Tumour (TGCT) is the most frequent tumour in the young male and its occurrence is increasing in Europe. Prognosis is favourable, and TGCT basically represents a model of curability of solid tumours. However, clinical management and follow-up of both …
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Phylogenetic studies into the development of foetal tissues and their neoplastic derivatives
Over a lifetime, each cell in the human body acquires a unique combination of somatic mutations that encode its ancestry, exposure to mutagens and strategy for optimising survival. Studies into normal and neoplastic tissues in adults have delineated clonal architecture and oncogenesis at an …