Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Geranylgeranylated"”.
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Increased Geranylgeranylated K-Ras Contributes to Antineoplastic Effects of Farnesyltransferase Inhibitors.
… signaling. N- and K-Ras can be alternatively geranylgeranylated (GG’d) if farnesylation is inhibited but are preferentially farnesylated.</p> <p>Small molecule inhibitors of farnesyltransferase (FTIs) have been developed as a means to alter Ras signaling. Our initial studies with FTIs in …
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Characterization Of Protein Prenyltransferases And Protein Prenylation In Plasmodium Falciparum
… evidence for the existence of farnesylated and geranylgeranylated malaria parasite proteins. The study shows that the dynamics of protein prenylation changes with the intraerythrocytic development cycle of the parasite. We detected that prenylated proteins in the 50 kDa range were mostly …
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Synthesis of Novel Isoprenoid Diphosphate Analogs as Chemical Tools to Investigate Protein Geranylgeranylation
… that would allow for the identification of geranylgeranylated proteins.</p> <p>The initial goal of this project was to advance our knowledge of GGTase-I substrate specificity in terms of both prenyl and protein substrates and to investigate GGTase-I versus FTase substrate specificity. The …
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Genetic Dissection of Heart Development in the Fruit Fly Drosophila Melanogaster
… pathway, and G-protein Ggamma 1, which is geranylgeranylated, thus representing an endpoint of isoprenoid biosynthesis. These findings reveal a cardial cell-autonomous requirement of Ggamma 1 geranylgeranylation for heart formation and suggest the involvement of the mevalonate pathway in …
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Statin-Mediated Attenuation of Chemokine Expression in Peripheral Nerve Vascular Endothelial Cells
… of MCP-1. We argue that identifying this precise geranylgeranylated target that mediates chemokine secretion will significantly advance the development of novel treatment options for patients with GBS.</p>
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The effects of statins on hypoxia-induced proliferation and cell signalling pathways in pulmonary artery fibroblasts
… related to the HMG-CoA pathway indicated that a geranylgeranylated protein, probably Rac1, had an obligatory role upstream of p38 MAPK, in this signalling pathway. Co-culture and conditioned media experiments with bovine PAFs and PASMCs demonstrated the release of PASMC mitogens from hypoxic …
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Reconstitution Of Rho Gtpase Interactions At The Membrane
… in vitro the interactions between the geranylgeranylated Rho GTPase Cdc42, RhoGDI, and liposomes of well-defined lipid composition. In taking advantage of the sensitivity and real-time capabilities of these reconstituted systems, some unexpected findings emerged regarding how RhoGDI …