Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Gephyrin"”.
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Identification of novel target genes for the plasticity-related transcription factor Zif268
… this thesis proposes two known proteins, gephyrin and ubiquilin, as well as a novel gene (urma), as potential downstream targets of Zif268. Both gephyrin and ubiquilin are associated with GABAA receptors at inhibitory synapses. Gephyrin is thought to cluster and anchor GABAA receptors at …
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Spinothalamic tract neurons in laminae I, III and IV of the rat: a retrograde neuronal tracing study
… for the glycine receptor-associated protein, gephyrin, and have a very high density of input from glutamatergic axons that contain vesicular glutamate transporter 2 (VGLUT2). These "large gephyrin-coated cells" in the lumbar cord are known to project to the LPb, but it is not yet known whether …
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Organization of Postsynaptic Proteins via the Neuronal Cytoskeleton
… of the inhibitory synaptic proteins GABAAR and gephyrin, which has a tubulin binding motif, were unaffected by depolymerization of the cytoskeleton, or detergent extraction. These studies reveal an unsuspected heterogeneity in the modes of attachment of postsynaptic proteins to the cytoskeleton, …
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PLASTIC CHANGES IN THE INHIBITORY GLYCINE SYSTEM OF THE DORSAL COCHLEAR NUCLEUS (DCN) IN A RAT MODEL OF TINNITUS
… glycine receptor subunits (GlyRs), gephyrin, BDNF and its receptor TrkB were assessed in dorsal cochlear nucleus (DCN) fusiform cells 4 months post exposure utilizing quantitative in situ hybridization and immunocytochemistry. Young exposed rats showed significant decreases of GlyR …
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Synaptic Protein Profiling in the Mammalian Brain
… in vitro, such as the scaffolding protein, gephyrin. The result of this work provides a novel approach for detailed investigations of the biochemical complexity of CNS synapse types.</p>
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Experience-dependent dendrite remodeling of GABAergic interneurons in the adult visual cortex
… by tagging fluorescent proteins to PSD95 and Gephyrin, respectively. Finally, we show that the fluorescent proteins, Teal and Venus, can be simultaneously excited and spectrally resolved through linear unmixing so that individual structural and synaptic components can be identified and …
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Inhibitory synapses are repeatedly assembled and removed at persistent sites in vivo
… interventions that influence the clustering of gephyrin, a scaffolding molecule that anchors inhibitory receptors at postsynaptic sites.
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DISRUPTION OF THE HIPPOCAMPAL GABAERGIC SYSTEM IN THE Fgf14 ̶ / ̶ MOUSE MODEL
… are relevant to cognitive impairment such as gephyrin, GABAA alpha-1, and alpha-2 receptor subunits. Interestingly, the results indicate genetic deletion of Fgf14 exhibit fewer effects on GABAergic postsynaptic components. Suggesting a potential role of FGF14 in regulating the GABAergic pre …
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Death, survival, and morphological development of hippocampal granule cells born in an inflammatory environment
The brain continues to form new neurons throughout life. This process of adult neurogenesis has been thoroughly documented in several species including birds, rodents and humans. Adult neurogenesis is not a global process, but is confined to two subcompartments of the brain; the subventricular zone …
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Repeated Zolpidem Treatment Effects on Sedative Tolerance, Withdrawal, mRNA Levels, and Protein Expression
… mRNA expression of α4, β1, γ2 subunits, GAT, and gephyrin in the cortex and significant decreases of α5- and β3-GABAAR </p> <p>subunits, and the GluN2A subunit in the hippocampus. Seven days of zolpidem resulted in a decrease in total α2 subunit protein level and 7 days of diazepam decreased total …