Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Genotype-Phenotype Map"”.
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Thermodynamics of neutral sets and sequence length changes in the genotype-phenotype map of RNA secondary structure
The genotype-phenotype (GP) map of RNA secondary structure connects RNA sequences and the corresponding folded molecular structures. This relationship is required for modelling the evolution of functional RNA structures. In this thesis, we fill two gaps in the understanding of the RNA GP map: we …
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Artificial evolution with Binary Decision Diagrams: a study in evolvability in neutral spaces
… biased distribution of functionality within the genotype-phenotype map, which serves to direct phenotypic variation. Neutrality facilitates fitness-conserving exploration, completely alleviating local optima. Population diversity, in conjunction with neutrality, is shown to facilitate the …
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Mapping Genotype to Phenotype with High-Throughput Empirical Approaches
… a central goal of biology. The structure of this genotype-phenotype map, or landscape, underlies the dynamics of populations adapting under natural selection, and quantitative understanding will be required to predict and engineer outcomes in evolving organisms like viral pathogens, cancer cells, …
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Evolutionary trade-offs and adaptive phenotypic plasticity under multidimensional selective pressure
… of evolutionary change. However, predicting how phenotypes respond to selective pressure via a quantitative theory of evolution remains challenging due to a number of factors complicating the genotype to phenotype map. Genetic architecture presents an internal source of complexity, constraining …
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Structural Properties of Genotype-Phenotype Maps: Models, Estimates and Evolution
Genotype-phenotype (GP) maps play a crucial role in evolution, as they set up a connection between the space of genotypes, on which mutations take place, and the space of phenotypes, which is affected by selection. This thesis studies a range of questions surrounding the structural properties of GP …
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Defining the Epigenetic Evolutionary Dynamics that Precede Acute Myeloid Leukaemia
… levels at specific CpGs, thus providing a genotype-phenotype map for certain driver mutations. Remarkably, we found that driver mutations in diverse AML-associated genes are associated with a convergent CpG phenotype. Statistical models for AML risk prediction based solely on methylation …