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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Genotoxic Effects"”.
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Genotoxic effects of oestrogens and nano-NSAIDs: Genotoxic effects of oestrogens in vivo and nano- and bulk forms of NSAIDs on blood samples from prostate cancer patients
The genotoxicological effects of five intra-peritoneal administered oestrogens (17β- oestradiol, daidzein, diethylstilboestrol, genistein, and equol), were examined. Male hooded- Lister rats were used to examine to what extent DNA damage occurred. The alkaline Comet assay was the chosen method used …
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Genotoxic effects of NSAIDs and hydrocortisone in bulk and nano forms in lymphocytes from patients with haematological cancers
… that anti-inflammatory agents have anti-tumour effects in cancers, with reduced metastases and mortality. Current use of anti-inflammatory agents in the treatment and prevention of cancer is limited by their toxicity and side effects. The emerging field of nanotechnology allows the fundamental …
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CYTO-GENOTOXIC EFFECTS OF SOME PHARMACEUTICAL AND PERSONAL CARE PRODUCTS (PPCPS) ON THE FRESHWATER BIVALVE ZEBRA MUSSEL (DREISSENA POLYMORPHA)
… for an accurate risk assessment since chronic effects are much more probable. In order to enlarge this topic, we decided to evaluate the potential cyto-genotoxicity of a common antimicrobial agent (triclosan; TCS), a widespread antibiotic (trimethoprim; TMP) and three largely used NSAIDs …
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Molecular mechanisms of myricetin bulk and nano forms mediating genoprotective and genotoxic effects in lymphocytes from pre-cancerous and myeloma patients
… conducted to investigate the genoprotective and genotoxic effects of myricetin nano and bulk forms on the lymphocytes from pre-cancerous and multiple myeloma cancer patients compared to those from healthy individuals. Also, to investigate the protective potential of myricetin bulk and nano …
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Molecular mechanisms of myricetin bulk and nano forms mediating genoprotective and genotoxic effects in lymphocytes from pre-cancerous and myeloma patients
… conducted to investigate the genoprotective and genotoxic effects of myricetin nano and bulk forms on the lymphocytes from pre-cancerous and multiple myeloma cancer patients compared to those from healthy individuals. Also, to investigate the protective potential of myricetin bulk and nano …
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Genotoxic effects in human peripheral lymphocytes from healthy individuals and head and neck cancer patients after treatment with hydrogen peroxide and pembrolizumab liposome
… The aim of this study was to investigate the effects of naked Pembrolizumab and Pembrolizumab liposome on the level of DNA damage, gene, and protein expressions in peripheral lymphocytes from HNC patients and compared to the healthy individuals by using the Comet and micronucleus assays. …
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Genotoxic effects of a novel form of Gold Nanoparticles loaded with Hesperidin on head and neck cancer lymphocytes compared to effects from healthy control lymphocytes and Squamous cell Carcinoma of Maxillary sinus
… therapeutic target. This study focused on the effects of 15μg/ml Hsp loaded on gold nanoparticles (Hsp-AuNPs) on 20 healthy individuals’ lymphocytes as compared to 20 HNC patients’ lymphocytes using the alkaline Comet assay. While enzyme-based Comet repair was performed on 5 healthy …
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Genotoxic effects of a novel form of Gold Nanoparticles loaded with Hesperidin on head and neck cancer lymphocytes compared to effects from healthy control lymphocytes and Squamous cell Carcinoma of Maxillary sinus
… therapeutic target. This study focused on the effects of 15μg/ml Hsp loaded on gold nanoparticles (Hsp-AuNPs) on 20 healthy individuals’ lymphocytes as compared to 20 HNC patients’ lymphocytes using the alkaline Comet assay. While enzyme-based Comet repair was performed on 5 healthy …
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Heavy metal toxicity in human lung fibroblasts and inhibition of human topoisomerase-I as a potential mechanism
… metals is not prohibited world-wide and their effects on human health are still obvious. Heavy metal resuspension, through the environmental dust and soil accumulation, make them a dangerous enemy for human health, as the exposure to them cannot be avoided. The genotoxic effects of most of the …
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In Vivo Interaction Between Health Food Supplements and Chemotherapeutic Agents on DNA Damage and Cell Production
… and/or cellular damage. SW affected to increase genotoxicity of bone marrow while the increased percentage of reticulocytes was observed. FL and RM10 were found to interact with Ara-C. Either the interaction of FL or RM10 with Ara-C resulted in decreased genotoxicity to bone marrow cells. Soy …
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Genotoxic effects of nano and bulk forms of aspirin and ibuprofen on blood samples from prostate cancer patients compared to those from healthy individuals: The protective effects of NSAIDs against oxidative damage, quantification of DNA repair capacity and major signal transduction pathways in lymphocytes from healthy individuals and prostate cancer patients
… mortality. NSAIDs are seriously limited by side effects and their toxicity, which can become cumulative with their long-term administration for chemoprevention. The huge development in nanotechnology allows the drugs to exhibit novel and significantly improved properties compared to the large …
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The Chemical-Induced Genotoxicity of Depleted Uranium
… little is known about the direct chemical genotoxicity of uranium. The overall hypothesis of the current research is that uranium can produce DNA damage by chemical genotoxicity mechanisms. Three specific aims were tested. In Aim 1, specific DNA lesions caused by direct interaction of …
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A Novel Drug Delivery System Incorporates a Functional Composite Scaffold Derived from Taxifolin with Potential Cytotoxic and Anticancer Effects on Triple Negative Breast Cancer
… of the flavonoid taxifolin and its cytotoxic and genotoxic effects on triple-negative breast cancer (TNBC) and blood cells from healthy individuals and breast cancer patients. Central to this work is the development of a novel taxifolin delivery system via electrospun PCL scaffolds to enhance …
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A Novel Drug Delivery System Incorporates a Functional Composite Scaffold Derived from Taxifolin with Potential Cytotoxic and Anticancer Effects on Triple Negative Breast Cancer
… of the flavonoid taxifolin and its cytotoxic and genotoxic effects on triple-negative breast cancer (TNBC) and blood cells from healthy individuals and breast cancer patients. Central to this work is the development of a novel taxifolin delivery system via electrospun PCL scaffolds to enhance …
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A Novel Drug Delivery System Incorporates a Functional Composite Scaffold Derived from Taxifolin with Potential Cytotoxic and Anticancer Effects on Triple Negative Breast Cancer
… of the flavonoid taxifolin and its cytotoxic and genotoxic effects on triple-negative breast cancer (TNBC) and blood cells from healthy individuals and breast cancer patients. Central to this work is the development of a novel taxifolin delivery system via electrospun PCL scaffolds to enhance …
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Comparison of Redox-Active and Conjugative Enzymes With and Without Efflux Transporters and Their Comparative Effectiveness in Protection Against Cellular Toxicity of 4-Hydroxy-2-Nonenal (HNE), an Aldehyde Lipid Peroxidation Production
… and has been demonstrated to have cytotoxic and genotoxic effects. Several oxidoreductases (ORs) have been reported to detoxify HNE including aldehyde dehydrogenase (ALDH) and aldo-keto reductases (AKRs). Glutathione S-transferases (GSTs) are known to play a role in the detoxification of HNE by …
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Evaluation of Anti-cancer effect of a Novel Formulation from Umbilical Cord Blood Stem CellDerived Exosomes and Retinoic acid as a potential therapeutic candidate against Malignant Melanoma
… The current in vitro study has evaluated the genotoxicity and cytotoxicity of RA and CBSC-derived exosomes, either alone or combined, on lymphocytes from healthy individuals and melanoma patients and on the CHL-1 and FM55 melanoma cell lines. The optimal doses were identified as 10 µM for RA …
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The use of different blood sample preparations in the development of biomarkers for the environmental monitoring of domestic farm animals
… the rat and sheep blood sample preparations to genotoxic compounds ex vivo showed that EMS caused comparable dose-dependent genotoxic effects in all sample preparations (fresh and frozen) as detected by the Comet assay. In contrast, the effects of CdCl2 were dependent on the duration of exposure …
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Fundamentals of heterogeneous photocatalysis ; and, Consequences of inorganic and organic UV sunblocks on DNA
… predicted. Further, the thesis focuses on the genotoxic effects of TiO 2 on DNA. The spectroscopic features of TiO 2 , make it an excellent UVA/UVB sunblock. We demonstrate that, when commercial TiO 2 specimens are illuminated with UV radiation, hydroxyl radicals are generated, which damage …
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