Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 186 for “"Genotoxic"”.
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Genotoxic remodeling of the host epithelium
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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OTULIN's Novel Regulatory Mechanisms in Genotoxic and Inflammatory NF-kB Signaling
… facilitate NF-kB signaling transduction upon genotoxic stress. OTU deubiquitinase with linear linkage specificity (OTULIN) is known to cleave linear ubiquitin chains exclusively. The purpose of this dissertation is to investigate whether OTULIN can counteract LUBAC-mediated NF-</p>
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Genotoxic effects of oestrogens and nano-NSAIDs: Genotoxic effects of oestrogens in vivo and nano- and bulk forms of NSAIDs on blood samples from prostate cancer patients
The genotoxicological effects of five intra-peritoneal administered oestrogens (17β- oestradiol, daidzein, diethylstilboestrol, genistein, and equol), were examined. Male hooded- Lister rats were used to examine to what extent DNA damage occurred. The alkaline Comet assay was the chosen method used …
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Investigation of the genotoxic potential of the marine biotoxins okadaic acid and azaspiracids
The present study investigated the genotoxic potential of the marine biotoxins okadaic acid (OA) and azaspiracids (AZAs). Harmful algae blooms (HABs) are an increasing global problem with implications for the ecosystem, economy and human health. Most data available on human intoxication are based …
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Influence of genotoxic drug-induced post-translational modifications on mutant p53 stability and oncogenic activities
The tumour suppressor p53 is often disrupted by missense mutations that can result in p53 protein accumulation and acquisition of novel oncogenic activities. Various studies have demonstrated that DNA-damaging drugs currently used in the clinic aimed at activating wild type p53, can also stabilise …
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Determination of genotoxic stress in feral populations of bullheads and carp using the alkaline single cell gel assay.
Monitoring genotoxicity of the environment using endemic organisms as sentinels requires the development of sensitive assays. Towards this end, I explored the feasibility of applying the ALKALINE SINGLE CELL GEL (SCG) or "COMET" ASSAY. This approach involves detection, under alkaline conditions, of …
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Genotoxic effects of NSAIDs and hydrocortisone in bulk and nano forms in lymphocytes from patients with haematological cancers
… and reduced dosage. In the present study, the genotoxic effects of three commonly used anti-inflammatory drugs; aspirin, ibuprofen and hydrocortisone, in their bulk and nano forms were evaluated on peripheral blood lymphocytes of healthy donors using the comet assay and the micronucleus assay. …
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CYTO-GENOTOXIC EFFECTS OF SOME PHARMACEUTICAL AND PERSONAL CARE PRODUCTS (PPCPS) ON THE FRESHWATER BIVALVE ZEBRA MUSSEL (DREISSENA POLYMORPHA)
… topic, we decided to evaluate the potential cyto-genotoxicity of a common antimicrobial agent (triclosan; TCS), a widespread antibiotic (trimethoprim; TMP) and three largely used NSAIDs (paracetamol; PCM – diclofenac; DCF – ibuprofen; IBU) on the freshwater bivalve zebra mussel (Dreissena …
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Modulation of Clr-b Ligand for the Inhibitory NKR-P1B NK Cell Receptor in Response to Transformation and Genotoxic Stress
… receptors. The recognition of targets undergoing genotoxic stress or transformation by NK cells has been limited to the upregulation of stimulatory NKG2DL and “missing-self” recognition of MHC-I. The ligand pair NKR-P1B:Clr-b participates in “missing-self” recognition of tumour and infected cells, …
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Synthesis and characterization of oligonucleotides containing deoxyxanthosine : a probe for the mutagentic and genotoxic activity of an oxidized DNA base
Thesis (M.S.)--Massachusetts Institute of Technology, Division of Toxicology, 1995.
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Molecular mechanisms of myricetin bulk and nano forms mediating genoprotective and genotoxic effects in lymphocytes from pre-cancerous and myeloma patients
… conducted to investigate the genoprotective and genotoxic effects of myricetin nano and bulk forms on the lymphocytes from pre-cancerous and multiple myeloma cancer patients compared to those from healthy individuals. Also, to investigate the protective potential of myricetin bulk and nano …
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Genotoxic effects in human peripheral lymphocytes from healthy individuals and head and neck cancer patients after treatment with hydrogen peroxide and pembrolizumab liposome
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide. It has commonly been associated with exposure to tobacco-derived carcinogens and alcohol consumption. Pembrolizumab has shown to be effective in the treatment of many types of cancers such as melanoma, …
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Effects of synbiotics on cancer risk biomarkers
… rats modulates the immune system, influences the genotoxic potential of caecal contents and reduces the number of colonic tumours compared to control rats who did not receive the synbiotic. The aim of the current study was to identify biomarkers suitable for use as cancer risk markers and as …
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An Evaluation of the Occurrence of Micronuclei and other Nuclear Abnormalities in Fishes from the Great Lakes Basin, United States
Biological markers (biomarkers) sensitive to genotoxic and mutagenic contamination in fishes are widely used to identify contamination in the aquatic environment. The "fish tumors or other deformities" biological use impairment (BUI) occurs at 18 of the 30 areas of concern (AOC) located in the …
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Human embryonic stem cells for genotoxicity testing
… cells commonly used in vitro to analyze the genotoxic potential of various agents, often poorly reflect human physiology. Lack of standardization also limits use of primary explanted cells. Human embryonic stem cells (hESCs) have been validated as a stable and healthy human cell source. This …
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In vitro chemically-induced DNA damage in cancer patients and healthy individuals. The effect of genotoxic compounds in cells from polyposis coli, colon cancer patients and healthy individuals.
In the present study DNA damage was measured in peripheral blood lymphocytes from polyposis coli and colorectal cancer patients, treated with different dietary and environmental compounds and compared with lymphocytes from healthy individuals. In addition, confounding factors such as age, gender, …
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