Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Genomic islands"”.
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Identifying The Structure Of Genomic Islands In Prokaryotes
… One of the important components of HGT is the genomic island (GI) which is a subsequence of the genome created by HGT. This research aims to identify the structures of the prokaryotic GIs that have a fundamental role in the adoption of prokaryotes and the impact of the species on the …
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The role of genomic islands in virulence of Pectobacterium carotovorum subspecies brasiliensis on potatoes
… have evolved through independent acquisition of genomic islands (GIs). GIs are large chromosomal regions in bacteria that are acquired by horizontal gene transfer and often encode virulence factors. To address this hypothesis, the genomes of P. carotovorum subsp. carotovorum strains associated …
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Development of new computational approaches for analysis and visualization of fluxes of genomic islands through bacterial species
Dissertation (MSc)--University of Pretoria, 2015.
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Genome analysis of Campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis
… of this thesis was therefore 1) To examine the genomic features of C. concisus strains of different genomospecies, and 2) To identify new potential virulence genes in C. concisus strains. In Chapter 2, genomes of 27 C. concisus strains were sequenced and an additional 9 publically available were …
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Computational Approaches to Detect Pathogens in the Presence of Complex Backgrounds
… examine a sample for the presence of pre-defined genomic signatures: short pathogen-specific DNA and/or RNA fragments. Identification of such signatures however, represents significant computational challenges. To be pathogen specific, each signature (or combination of signatures) must be present …
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Acquisition and Exclusion of Pathogenicity Island 1 (PAPI-1) in Pseudomonas Aeruginosa
… and adaptation. Conjugative transfer of genomic islands (GIs) has recently been reported in the opportunistic pathogen Pseudomonas aeruginosa. PAPI-1, one of the largest pathogenicity islands of P. aeruginosa, encodes several putative virulence genes and a major regulator of biofilm …
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The role of international ‘high-risk clones’ in the emergence of metallo-b-lactamase-producing pseudomonas aeruginosa in the UK
… one (VI) was located on a plasmid. VIM-encoding genomic islands were characterised in representatives of STs 111, 233 and 235 using whole genome sequencing (WGS) methods. SNP analysis achieved greater discrimination among MBL-producing representatives of STs 111 and 235. CRISPR-Cas bacterial …
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The in planta role of the global regulator Lrp in the bacterial phytopathogen Pantoea stewartii subsp. stewartii
… a recent common ancestral gene. Examining the genomic islands present in P. stewartii, it is possible to begin to predict where some of the genes which have functions involved in plant colonization may have originated. Overall, the results collected from the studies in this thesis contribute to …
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The genetics and phenotypes of Pseudomonas aeruginosa biofilm dispersal populations
… virulent PA14, due to the presence of multiple genomic islands shared between the strains. It was found that several genes were deleted in 18A and that could explain the phenotypic differences, such as poor biofilm formation compared to PAO1. These studies could provide insight to better …
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Phylogenetic and functional characterization of human microbiome intra-species diversity and tracking of early-life transmission
… allowed to reach strain-level resolution in metagenomic analysis. In this thesis, I present systematic approaches to study the strain-level variation using complementary phylogenetic and pangenomic methods aiming to address fundamental questions about microbiome transmission in early life as well …
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A multi-omics perspective on the biology and evolution of the genus Macrococcus
… as a potential new pathogen. Additionally, genomic insights into the genomes of some members of this genus demonstrate the potential for these organisms to serve as reservoirs of methicillin resistance determinants. Considering that strains of the M. caseolyticus species have been associated …
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Analysis of the genome organization and fitness traits of non-pathogenic Escherichia coli strain Nissle 1917 (O6:K5:H1)
… against infectious agents. Together with the genomic approach, other molecular biological methods such as PCR, DNA-chip technology, subtractive hybridization, transcriptomics and proteomics are of increasing importance for research on infectious diseases and public health. The aim of this work …
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Genome evolutionary studies of the Salmonella enterica serovars: implications for the dynamics of horizontal gene transfer, the pangenome concept, and bacterial and archaeal taxonomy
… acquired genes, including many important genomic islands, are similar to the codon usages of the most recently acquired genes of the accessory supraspecies pangenome. These findings challenge the dogma on the fate of horizontally acquired genes, and ultimately lead us to the proposal of …