Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Genomic evolution"”.
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Genomic Evolution in the Oomycetes
… have generated large amounts of oomycete genomic data. Availability of which facilitated bioinformatic characterisation of the secretomes of diverse oomycete species. Using comparative genomic, network, and phylogenetic methods, this thesis reports the identification of lineage and …
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Deciphering Genomic Evolution: From Early Breast Cancer Stages to Invasive Carcinoma
This dissertation investigates the evolution of ductal carcinoma in situ (DCIS) to invasive forms such as invasive ductal carcinoma (IDC) at the individual patient level. DCIS is considered a non-obligatory precursor of IDC, being the predominant form of breast cancer detected and comprising …
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Genomic Evolution of Chemoresistance In Triple-Negative Breast Cancer Delineated By Single Cell Sequencing
… neoadjuvant chemotherapy (NAC). Currently, the genomic basis of chemoresistance remains poorly understood. An important question is whether resistance to chemotherapy is driven by the selection of rare pre-existing subclones with genomic mutations and transcriptional programs that confer …
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The Role of Polyploidy in Phenotypic and Genomic Evolution in the Shy Monkeyflower, <i>Mimulus sookensis<i>
<p>In an ever-changing world, evolution is an essential process that may allow organisms to adapt to their environment through natural selection. All evolutionary processes act through a single fundamental medium: genetic variation. Polyploidy, or whole genome duplication, is a major mechanism for …
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Isolation and Characterization of a Full Length Retrotransposon: CR1
… genomes and have clearly had a major impact on genomic evolution. The described research takes advantage of an abundant transposable element present in the genomes of Anseriformes, called Chicken Repeat 1 (CR1). Previous studies in Anseriformes suggest that CR1 is presently active in recent …
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Investigating Invasion In Ductal Carcinoma In Situ With to pographical Single Cell Genome Sequencing
… invasion in which it is possible to delineate genomic evolution during invasion because of the presence of both in situ and invasive regions within the same sample. While laser capture microdissection studies of DCIS-IDC examined the relationship between the paired in situ (DCIS) and invasive …
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Quantifying evolution and natural selection in vertebrate noncoding sequence
When studying genomic evolution, biologists find it important to identify varying patterns of natural selection. Many traditional methods of classifying directional selection have relied on models that categorize mutations as function-altering or neutral, and then comparing the rates of the two …
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Revealing the Mechanisms of Tumorigenesis Through Multi-Omics Analyses
… system shaped by dynamic interactions across genomic and environmental scales. Advances in research have revealed a multifaceted etiology of tumorigenesis, extending from just hallmark oncogenic mutations to include large-scale genomic alterations, transcriptomic dysregulation, epigenetic …
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Evolution of the genome in myeloproliferative neoplasms and the methylome in blood
… generation sequencing (NGS) has unlocked the genomics of normal and diseased haematopoiesis, providing remarkable insights into the rates that mutations are acquired throughout life, mutations that drive disease and the growth rates of clones that acquire driver mutations. Such metrics for DNA …
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The genomic and genetic basis of mammalian sexual reproduction : sequence of the mouse Y chromosome, and a gene regulatory program for meiotic prophase
… haploid gametes. In this thesis, I examined the genomic evolution of the mouse Y chromosome, which instructs sexual determination, and genetic regulation of a program of gene expression for meiosis, a specialized cell cycle which gives rise to haploid gametes. Chapter 2 describes the study of the …
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The study of ancient viral class II envelope fusion proteins within the viral retroelements of Nematoda and the nuclear plasmids of Dictyostelium
… viruses, plasmids, and transposons) in host genomic evolution, horizontal gene transfer, and virus evolution. The work presented in this thesis highlights the role viral fusion proteins and their homologues in biological development and the evolution of sex. It demonstrates the potential of …
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Computational Approaches to Understand Chemoresistance & Tumor Evolution Using Longitudinal Clinical Data and Lineage Tracing
… ductal carcinoma in situ (PDAC) from an evolutionary perspective.</p> <p>The first approach was to leverage tumor profiling from an ongoing randomized clinical trial in triple-negative breast cancer (ARTEMIS) to assess mechanisms of chemo-resistance, and use longitudinally tracked patient …
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Investigating The Ecology and Evolution of Normal Breast Tissues and Breast Cancer With Single Cell Genomics
… and having a 5-year survival of <30%. Tumor evolution and changes in components of the tumor microenvironment (TME) such as cancer associated fibroblasts (CAFs), tumor associated macrophages (TAMs), and tumor endothelial cells (TECs), have shown to play a role in tumor progression. One …