Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Genomic epidemiology"”.
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Wastewater-Based Genomic Epidemiology
… successive waves of infection and reinfection. Genomic surveillance has become a cornerstone of pathogen monitoring, but clinical sequencing remains expensive, logistically demanding and biased by non-random testing. Wastewater–based epidemiology (WBE), whose origins trace back almost a century, …
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Genomic epidemiology of oat crown rust disease in Australia and abroad uncovers diverse mechanisms to generate diversity
Rust fungi are a diverse group of plant pathogens consisting of over 8,000 species in the Basidiomycete order Pucciniales. They parasitize numerous plants of agricultural and ecological importance, such as cereals, legumes, and trees. Like plants, rust fungi undergo alternation of generations …
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Genomic epidemiology of oat crown rust disease in Australia and abroad uncovers diverse mechanisms to generate diversity
Rust fungi are a diverse group of plant pathogens consisting of over 8,000 species in the Basidiomycete order Pucciniales. They parasitize numerous plants of agricultural and ecological importance, such as cereals, legumes, and trees. Like plants, rust fungi undergo alternation of generations …
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Applying at scale genomic and phenotypic approaches to study pathogens linked to nosocomial transmission and disease
… Hospitals, I have utilised a combination of genomic, epidemiological and clinical datasets to characterise these pathogens. Phylogenetic analysis of K. pneumoniae bacteraemia isolates from a four year period show considerable genomic diversity and possible cryptic transmission events …
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Pathogen phylogenies for public health
… in genome-wide association studies (GWAS) and genomic epidemiology. First, I show that correlations in an infectious disease trait due to shared pathogen ancestry can reduce GWAS power. I extend a statistical model of evolution to estimate and correct for these correlations. Second, I apply a …
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The evolution of virulence in Candida auris determined through experimental, ecological and epidemiological approaches
… I begin by reviewing what is known concern- ing genomic innovation strategies and the evolution of pathogenicity in C. auris (Chapter 1). I developed a thermotolerant fish embryo model (Aphanius dispar) to interrogate host-pathogen gene expres- sion programmes across five clades (Chapter 2), and …
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Exploring the genomic and phenotypic diversity of the Vibrio cholerae species
… of the Argentinian cholera epidemic using genomic epidemiology approaches, and to contrast this pandemic lineage to the non-epidemic V. cholerae that were present in Argentina at the same time as the pandemic lineage. I then present a study of important recent and historical V. cholerae …
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Phylogenetic approaches for quantifying the genotypic diversity of influenza viruses
Wild aquatic birds are thought to be the main reservoir for Influenza A viruses, hosting the largest burden of influenza diversity generated by high frequencies of co-infection and segment reassortment. The recently emerged avian influenza viruses that spilled-over into the human population were …
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Development and application of genomic tools for characterising genetic variation in soil-transmitted helminths
… the feasibility of low-depth shotgun metagenomic analysis, also known as ‘genome skimming,’ using faecal samples to diagnose helminth infections and recover genetic information from helminths; (ii) examine the genetic variation of nuclear and mitochondrial DNA targets associated with STHs …
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EPIDEMIOLOGIA GENOMICA DELLE PRINCIPALI VARIANTI DI SARS-COV-2 CIRCOLANTI IN ITALIA PRIMA E DURANTE L'ERA OMICRON
GENOMIC EPIDEMIOLOGY OF THE MAIN VARIANTS OF SARS-CoV-2 CIRCULATING IN ITALY BEFORE AND DURING THE OMICRON ERA Introduction Since the beginning of the pandemic, SARS-CoV-2 has shown a great genomic variability, resulting in the continuous emergence of new variants that has made their global …
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High-throughput sequencing to understand pathogen carriage and transmission
Genomic sequencing is a powerful technology in the study of pathogen biology and pathogen transmission. In this thesis I have studied the human nasal carriage of *Staphylococcus aureus* and, in response to the SARS-CoV-2 pandemic, I examine the transmission of SARS-CoV-2, two critically important …
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Studies on severe acute respiratory syndrome coronavirus type -2 in Northern South Africa
… exists on human coronavirus (HCoV) molecular epidemiology, and circulation in different populations in Africa. As the COVID-19 pandemic progressed across the globe, wastewater-based epidemiology (WBE) was proposed as an alternative tool for assessing and monitoring the occurrence of severe …
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FUSARIUM MUSAE, A NEW POTENTIAL TRANSKINGDOM PATHOGEN.
… an initial comprehensive view of F. musae genomics, while mitochondrial haplotype comparisons revealed potential cross-host transmission events. In vitro sensitivity tests revealed that F. musae is less susceptible to azole treatments than F. verticillioides, potentially offering it …