Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Genomic Surveillance"”.
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AN IMPROVED GENOMIC SURVEILLANCE APPROACH TO DISSECT THE SARS-COV-2 PANDEMIC
Genomic surveillance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the only approach to rapidly monitor and tackle emerging variants of concern (VOC) of the COVID-19 pandemic. Such scrutiny is crucial to limit the spread of VOC that might escape the immune protection conferred …
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Genomic surveillance of methicillin-resistant Staphylococcus aureus at local, regional and national levels
… WGS is still not implemented in the routine surveillance of MRSA at a local, regional or national level. This thesis applies WGS to a number of questions and populations to describe its benefits. Standard infection control investigation commonly uses the antimicrobial susceptibility patterns …
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GENOMIC SURVEILLANCE AND RISK-BASED ASSESSMENT OF ANTIBIOTIC RESISTANCE TRANSMISSION ACROSS TROPICAL AQUATIC ENVIRONMENTS
… poses a growing public health threat, yet the genomic mechanisms governing resistance gene flow across interconnected water systems remain poorly understood. This thesis investigates β-lactam resistance transmission across Singapore's tropical aquatic continuum—from hospital sewage and …
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Development of genomic surveillance and disinfection technologies to control virus transmission in the environment
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Wastewater-Based Genomic Epidemiology
… successive waves of infection and reinfection. Genomic surveillance has become a cornerstone of pathogen monitoring, but clinical sequencing remains expensive, logistically demanding and biased by non-random testing. Wastewater–based epidemiology (WBE), whose origins trace back almost a century, …
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The application of clinical metagenomics to central nervous system infections in a resource-limited setting
Clinical metagenomic sequencing (CMS) is a powerful tool that can overcome both the need for pathogen viability and a priori test selection, but infrastructure, expertise and reagent costs limit its accessibility, particularly in low- and middle-income countries. The recent expansion of genomic …
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COVID-19 Variant Analyzer through Genomic Sequences and Jaccard Similarities
… has underscored the urgent need for efficient genomic surveillance to track the emergence and spread of SARS-CoV-2 variants. This study developed a novel computational framework to enhance variant detection by leveraging a database-driven approach and genomic sequence analysis. The framework …
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Antimalarial Drug Resistance: Mechanisms of Emergence in Low-Transmission Settings
… and there is consequently widespread interest in genomic surveillance and antimalarial sensitivity profiling of parasites from low-transmission areas. The Greater Mekong Subregion is one such region and has been extensively researched, however other regions such as South America in general, and …
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Análise do perfil epidemiológico e molecular do SARS-CoV-2 em dois municípios do estado da Bahia entre 2020 e 2022.
… inequalities, and is essential for effective genomic surveillance. In this context, investigating circulating viral lineages and individual responses to infection may contribute to control strategies and support the understanding of disease severity and immune responses in confirmed SARS-CoV-2 …
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The genomic characterization of carbapenemase-producing Serratia marcescens at a tertiary hospital in South Africa
… in this organism. There is a paucity in genomic data for carbapenem resistant S. marcescens (CRSM). Methods A retrospective cohort study describing laboratory confirmed CRSM from a tertiary academic hospital in Cape Town, South Africa, for the period 2015-2020, was performed. Stored CRSM …
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Applications, complexities, and opportunities of metagenomics for clinical diagnostics and viral discovery
Metagenomic next-generation sequencing (mNGS) has transformed infectious disease research by enabling broad-range detection of microbial nucleic acids from clinical and environmental samples. However, despite its growing adoption in diagnostic and surveillance settings, substantial variability in …
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Genomics & Gastroenteritis - A Journey in Applied Epidemiology
… a data analysis project which examined the genomic diversity of Salmonella Typhimurium in Victoria between 2018-2020, to inform the implementation of whole genome sequencing (WGS) as a tool for routine surveillance. As an outcome of this work, I was able to assist the OzFoodNet team at DH in …
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Genomics & Gastroenteritis - A Journey in Applied Epidemiology
… a data analysis project which examined the genomic diversity of Salmonella Typhimurium in Victoria between 2018-2020, to inform the implementation of whole genome sequencing (WGS) as a tool for routine surveillance. As an outcome of this work, I was able to assist the OzFoodNet team at DH in …
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Studies on severe acute respiratory syndrome coronavirus type -2 in Northern South Africa
… level. Additionally, through wastewater-based genomic surveillance of SARS-CoV-2, the evolutionary patterns and distribution of viral types at the population level can be comprehensively characterized. This study systematically reviewed literature published prior to the SARS-CoV-2 outbreak to …
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The relative importance of human and animal sources of vancomycin-resistant Enterococcus faecium in immunocompromised patients in hospital
… aims of my PhD were to use epidemiological and genomic surveillance data to establish risk factors for acquisition and infection with E. faecium in patients at CUH, and to use a One Health approach to consider possible sources for hospital patients by relating bloodstream-associated isolates …
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Genetic diversity of Anopheles mosquitoes
… MalariaGEN Vector Observatory Anopheles funestus Genomic Surveillance Project phase 1.0 dataset (vobs-funestus phase 1.0 for short) consists of whole genome sequence data for 656 samples from 13 different countries in sub-Saharan Africa. Different analysis methods, including PCA, ADMIXTURE and …
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Impacts of Habitat, Resource Addition, and Predator Exclusion on Rodent Community Structure and Hantaviruses in the Neotropics
… of what drives them is lacking. Moreover, genomic surveillance in wildlife populations is critical for risk assessment and mitigation. Herein, using data collected from field studies within the Reserva Natural del Bosque Mbaracayú (RNBM), a protected area of the Interior Atlantic Forest …
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Testing for host adaptive evolution using the maize streak virus model
… of new, fitter MSV variants, continuous genomic surveillance of MSV is therefore important. Based on analyses of full genome sequences, MSV-A has been classified into five subtypes (-A1, -A2, -A3, -A4, and -A6) and more than 20 recombinant lineages. Here, I showed using laboratory-based …
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Novel proapoptotic p63 isoforms are driven by an endogenous retrovirus in the male germ line of humans and great apes, likely increasing genome stability
TAp63, ein Homolog des Tumorsuppressors p53, hat die Fähigkeit, die weibliche Keimbahn zu beschützen, indem es Oozyten mit schweren DNA-Schäden nach Bestrahlung eliminiert. Obwohl die Expression von TAp63 in männlichen Keimbahnzellen vermutet wird, ist noch unklar, ob TAp63 auch als Wächter der …