Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 65 for “"Genomic Sequences"”.
-
Exploration of Microbial Genomic Sequences via Comparative Analysis
… programs for identifying likely protein coding sequences in prokaryotic DNA by combining comparative analysis of DNA sequences with more common noncomparative methods. In the comparative component of the analysis, regions of DNA are aligned with related sequences from the DNA databases; if the …
-
COVID-19 Variant Analyzer through Genomic Sequences and Jaccard Similarities
… has underscored the urgent need for efficient genomic surveillance to track the emergence and spread of SARS-CoV-2 variants. This study developed a novel computational framework to enhance variant detection by leveraging a database-driven approach and genomic sequence analysis. The framework …
-
Taxonomic classification of genomic sequences : from whole genomes to environmental genomic fragments
… develop a classifier for assigning environmental genomic fragments to the closest known source organism. This has been achieved by the development of a novel method for the TAxonomic COmposition Analysis - TACOA - of environmental genomic fragments using a kernelized nearest neighbor approach. A …
-
Isolation, characterization and expression ofcDNA and genomic sequences encoding ribulosebisphosphate carboxylase/oxygenase activase from barley
Ribulosebisphosphate carboxylase/oxygenase (EC 4.1.1.39, rubisco) catalyzes either the carboxylation or oxygenation of ribulose-1,5-bisphosphate (RuBP) to initiate either the Calvin cycle or the photorespiratory pathway. Rubisco needs to be activated in order to catalyze these reactions. Rubisco …
-
From single genomes to natural microbial communities : novel methods for the high-throughput analysis of genomic sequences
… provide the opportunity to rapidly produce vast genomic data sets at a low price. In particular, the recently developed, ultra-fast 454 pyrosequencing has dramatically reduced the cost and time requirements per sequenced base pair. Furthermore, novel methods have been developed that enable …
-
Bioinformatics approaches to large scale genome comparison, including the identification of conserved noncoding regions
The repeatitive pattern of genomic DNA reveals much about the structure and organization of genomes. REPuter is a bioinformatics tool that efficiently finds repeatitive substrings in large genomic sequences. The identification of repeats enables a wide range of biological interpretations. Here we …
-
Algorithms for discovering disease genes by integrating 'omics data
… as one of the biggest challenges in the post-genomic era. Information useful for mechanistic understanding of diseases comes from different types of “-omic” data, including genomic sequences, gene expression, and molecular interactions. Genome Wide Association Studies (GWAS) compare …
-
Finding Succinct Representations For Clusters
… We also show applications to explain clusters of genomic sequences that represent different threat levels
-
Gene prediction with conditional random fields
… protein-coding genes is crucial for subsequent genomic analysis. The rapid advance of sequencing technology has created a gap between genomic sequences and their annotations. Automated annotation methods are needed to bridge this gap, but existing solutions based on hidden Markov models cannot …
-
Engineering structural variants with prime editing
… programmable and scalable manipulation of genomic sequences. Prime editing has emerged as a powerful tool to introduce virtually any type of edit with high precision, but editing efficiency varies between edit types. While first insights into determinants have been gained for small edits, …
-
Identification and characterization of conserved regulatory elements by comparative genomics
… selected CNEs in transgenic mice. To this end, genomic sequences for 50 human genes were aligned with their orthologous sequences in mouse and fugu. 206 CNEs associated with 29 genes were identified using the criteria of at least 60% identity over 50 bp. CNEs associated with two transcription …
-
Biosynthesis of Fluorinated Natural Product Nucleocidin
… artificial chromosome library of the S. calvus genomic DNA, yielding six clones containing the predicted gene cluster. In this thesis, the plasmids containing the nucleocidin gene cluster and large flanking genomic sequences have been introduced into Streptomyces albus and Streptomyces lividans …
-
PROBLEMI DI CLUSTERING CON VINCOLI: ALGORITMI E COMPLESSITÀ
… the Localization of promoter regions in genomic sequences. The results are compared with those obtained through another methodology (MADAP).
-
Global Microsatellite Content Potentially Distinguishes Humans, Primates, Animals, and Plants
Microsatellites are highly mutable, repetitive sequences commonly used as genetic markers, but they have never been assayed en masse. Using a custom microarray to measure hybridization intensities of every possible repetitive nucleotide motif from 1-mers to 6-mers, we examined 25 genomes. Here we …
-
Messenger RNA Destabilization by -1 Programmed Ribosomal Frameshifting
… frameshifting (-1 PRF) signals in eukaryotic genomic sequences, and suggested a role in mRNA stability. This work improves and extends the computational methods used to search for potential -1 PRF signals. It continues to examine four yeast -1 PRF signals and show that they promote significant …
-
Molecular cloning, characterization, and expression of 3-hydroxy-3-methylglutaryl coenzyme a reductase gene from tomato
… responses in plants, we utilized yeast HMGR cDNA sequences to isolate tomato genomic sequences encoding HMGR. The nucleic acid sequence and gene structure was determined. The tomato HMGR gene (HMG2) contains four exons separated by three introns and encodes a polypeptide of 602 amino acid residues …
-
Discovery of Function in the Enolase Superfamily
In the genomic era, advanced sequencing techniques have enabled an exponential growth of the protein sequence databases. Although the abundance of genomic sequences is valuable, the correctness of the gene annotations poses a problem--approximately one-half of the deposited sequences are …
-
The Role of Genomic Sequence in the Spatial and Temporal Propagation of Heterochromatin
<p>Characterizing how genomic sequence interacts with trans-acting regulatory factors to implement a program of gene expression in eukaryotic organisms is critical to our understanding of genome function. One means by which patterns of gene expression are achieved is through the differential …
-
Rarity of Novel microRNAs in the Mouse Inner Ear
… predictions based on bioinformatic analyses of genomic sequences suggest that the number of mammalian miRNA genes might be as great as 1000. Furthermore, most methodologies for microRNA detection only access known microRNAs. In order to gain a comprehensive knowledge of the microRNAs involved in …
-
Characterization and Transcriptional Control of the Rabbit Cytochrome P450pbii Genes (Evolution, Isozymes)
… mapping and DNA sequencing lambda phage genomic clones corresponding to the genes for P-450PBc2, P-450PBc3 and P-450 (form 1). Comparison of the cloned genomic sequences with cDNA sequences established that genomic clone 6 contained the 5'-flanking region and the first six exons of the …
Page 1 of 4