Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Genomic Mutation"”.
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Evolutionary Instability Of Genomic Mutation Rate In Rapidly Adapting Asexual Mutator Escherichia Coli Populations
Alleles conferring higher mutation rates (mutators) can fix in asexual populations through a process called ‘mutator hitchhiking’. Theory predicts that repeated mutator hitchhiking can occur in an adapting asexual mutator population. I tested this prediction in two settings: a mutL- population …
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Attributed Graph Classification via Deep Graph Convolutional Neural Networks
… graph dataset of gene interaction networks with genomic mutation attributes as the attributes of the vertices. In several experiments on these datasets, we demonstrate that AGCP yields better results in terms of classification accuracy relative to the previously proposed models by a considerable …
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Concomitant Targeting of The Mtor/Mapk Pathways: Novel Therapeutic Strategy In Subsets of Non-Small Cell Lung Cancer
… to available therapies. Herein, we utilized genomic mutation data from advanced chemorefractory non-small cell lung cancer (NSCLC) patients enrolled in the Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE-2) clinical trial to characterize novel …
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Dynamic Mutation Rates and Extinction in Sexual Organisms
I analyzed the dynamics of the mutation rate in both finite and infinite randomly-mating populations. Germ-line mutator alleles, alleles that increase the genomic mutation rate, frequently occur when mutations alter the structure or regulation of genes involved in DNA repair, a fraction of the …
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Identification and characterization of components that overcome secretion limitations of the yeast Pichia pastoris
… cerevisiae have been engineered, through random genomic mutation, that are capable of overcoming these /ram-acting factors to secrete high levels of foreign protein. The Lin-Cereghino laboratory at University of the Pacific has developed a screen to identify mutations in P. pastoris capable of …
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Transcriptomics-based study reveals a novel link between arginine methylation and phosphate regulation in Saccharomyces cerevisiae
… was methylated by Hmt1 in vitro at Arg-241. Genomic mutation of Arg- 241 to Lys in wild type produced to the same phenotype as hmt1/J.. This is the first study to establish a link between arginine methylation and phosphate regulation. As polyphosphate is a source of phosphate, ATP and energy …
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Bioluminescence-Based High Precision Bacterial Growth Rate Measurements and Their Potential Application in Quantifying Deleterious Effects of High Mutation Rates
<p>The genomic mutation rate of wild-type Escherichia coli is 3E-3 per generation, a value that is shared by many DNA-based microbes and viruses. A majority of clinical isolates of E. coli also have a mutation rate that is close to the wild-type value. These findings raise the possibility that the …
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An exploration of mutation effect sizes in the nematode Caenorhabditis elegans
<p>Mutation rates vary within and among species, in part reflecting the variable input of the two main sources of mutation, DNA replication errors and DNA damage. In somatic tissues, oxidative damage resulting from free radical attacks on DNA is an important and well-characterized cause of …
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Bayesian Integration and Modeling for Next-generation Sequencing Data Analysis
… meaningful information from large-scale genomic data. Next-generation Sequencing (NGS) can now produce high quality data at DNA and RNA levels. However, in cells there exist a lot of non-specific (background) signals that affect the detection accuracy of true (foreground) signals. In this …
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Array-based genomic diversity measures portray Mus musculus phylogenetic and genealogical relationships, and detect genetic variation among C57Bl/6J mice and between tissues of the same mouse
Mouse models lack affordable genomic technologies slowing the identification of candidate variants contributing to complex phenotypes. The Mouse Diversity Genotyping Array (MDGA) is a low cost, high-resolution platform permitting genomic diversity assessment. Using a validated list of >500,000 …