Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 185 for “"Genomic Instability"”.
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DNA repair and genomic instability in yeast aging
… aging in budding yeast S. cerevisiae. Genomic instability can cause ERCs to excise from chromosomal rDNA arrays, containing 35S and 5S rRNA genes. At each cell division, ERCs replicate via an origin of replication present in each rDNA repeat, accumulate asymmetrically in the mother …
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Causes and Consequences of Genomic Instability in Prostatic Carcinogenesis
… is characterised by a number of particular genomic abnormalities that are predominantly generated in the preneoplastic phase. Whilst there are numerous candidates for the cause of these alterations, telomere dysfunction is thought to be a major contributor. Telomeres are the terminal ends of …
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Radiation-induced genomic instability and cellular communication: mechanistic investigations
… the bystander effect (BE). BE can also lead to genomic instability (GI) within the progeny of bystander cells, similar to the progeny of directly irradiated cells. The molecular factors that mediate this cellular communication can be transferred between cells via gap junctions or be released …
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The role of lysosomes in radiation induced genomic instability
… encompassed within the NTE paradigm are termed genomic instability (GI) and bystander effects (BE). GI can be described as an increase in rate of genetic alterations many cell generations after the initial radi- ation exposure. BE can be defined as the manifestation of radiation like effects in …
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Tracking profiles of genomic instability in spontaneous transformation and tumorigenesis
… findings of the current study are, 1) Genomic instability was apparent from the earliest stages of study, 2) Karyotypic heterogeneity was widespread, showed a pattern of expansion over time and preceded the acquisition of the transformed phenotype 3) a major karyotypic shift occurred …
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Investigations into the mechanism of genomic instability in renal cell carcinoma
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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FROM MICRONUCLEI TO EMT: MOLECULAR MECHANISMS OF GENOMIC INSTABILITY AND CELLULAR PLASTICITY
Chromosomal instability and its cellular consequences represent critical aspects of cancer progression and genomic instability. The research presented in this thesis encompasses two complementary projects, focusing on distinct yet interconnected molecular pathways. The first project investigates …
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Understanding The Mechanism of Genomic Instability During Replicative Aging In Budding Yeast
… most important hallmarks of aging is increased genomic instability. However, there remains much ambiguity as to the cause. I am studying the replicative life span (RLS) of the genetically tractable model organism Saccharomyces cerevisiae, or budding yeast using the innovative “mother enrichment …
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Genomic Instability and the Oncohistone H3K27M Drive Gliomagenesis in a Murine Model
… (HGG) formation resulting from elevated genome instability by DNA damage accumulation during embryogenesis. Furthermore, the presence of the oncohistone H3K27M mutation, commonly found in pediatric HGGs, enhances genome instability and accelerates cortical gliomagenesis with p53 inactivation and …
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THE ROLE OF RETROTRANSPOSITION AND EXOSOMAL DNA IN RADIATION-INDUCED GENOMIC INSTABILITY
Radiation-induced genomic instability (RIGI) is characterized by an increased rate of genomic alterations including delayed mutations, chromosomal aberrations, and micronucleus formation in the descendants of irradiated cells many generations after the initial radiation insult. At present the …
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Mechanisms of apoptosis modulation and their contribution to genomic instability in tumor cells
… to investigate the balance between formation of genomic damage and induction of apoptosis under genotoxic stress. After genotoxic insult there are different possibilities for the fate of a cell (Figure 1). The genomic integrity is analyzed at cellular checkpoints, usually leading to a delay in …
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Analysis of the relationship between genomic instability, heterozygosity levels and phenotype in Saccharomyces cerevisiae
… was the characterization of two forces, genomic instability and natural selection, that significantly impact genome structure by influencing the levels of genomic heterozygosity. While genomic instability processes can act to erode heterozygosity from the genome, natural selection may …
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Genomic Instability and Gene Dosage Obscures Clues to Virulence Mechanisms of F. tularensis species
… the different strains. This comprehensive genomic analysis revealed the critical role of transposable elements in inducing genomic instability resulting in large du-plications and deletions in the genomes of the chemical mutant and the complemented clones that in turn affect gene dosage and …
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The Adenylate-Uridylate-Rich element RNA binding protein ZFP36L1 suppresses replication stress-induced genomic instability
… results in hallmarks of RS-associated genomic instability in a cellular model depleted of ZFP36L1 using CRISPR/Cas9. We find that loss of ZFP36L1 results in defects in mitosis leading to chromosome segregation errors and genomic instability. Remarkably, we also identify loss of ZFP36L1 …
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The Role of the RNA-binding Protein ZFP36L1 in Suppression of Replication Stress-induced Genomic Instability
… and the consequent failure to preserve genomic stability. ZFP36L1, a member of the ZFP36 family of CCCH tandem zinc finger (ZF) proteins, is an RNA-binding protein that plays a crucial role in the post-transcriptional regulation of gene expression underlying physiological processes and …
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Regulation of the Insulin-like Growth Factor 1-Secretory Clusterin Expression Axis in Genomic Instability and Cell Stress
… Elevated basal IGF-1-sCLU signaling was noted in genomically unstable cells, whether they were deficient in DNA repair factors or telomerase function. ATM function was necessary for induction of sCLU after IR, and for maintaining elevated expression of sCLU in genomically unstable cells. p53 …
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Low Molecular Weight Cyclin E Deregulates Dna Replication and Damage Repair to Promote Genomic Instability In Breast Cancer
… we tested the hypothesis that LMW-E promotes genomic instability by deregulating DNA replication and damage repair. We generated immortalized pre-cancerous human mammary epithelial cells (hMECs) engineered to express doxycycline inducible LMW-E or FL-cycE in <em>CCNE1</em> knock-out …
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Investigation of Genomic Instability Induced By G-Quadruplexes In The Absence of Functional to poisomerase 1 In Yeast
… reduces co-transcriptional G4 DNA-associated genomic instability at a model G4-motif in <em>Saccharomyces cerevisiae</em>. However, whether Top1 suppresses G4-formation on a genome-wide scale in yeast remains unexplored. Therefore, I aimed to uncover if deletion of Top1 enhances genome-wide …
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