Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"Genome-wide RNAi screen"”.
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A Genome-Wide RNAi Screen Identifies CDC-42 and GDI-1 as In Vivo Regulators of Invadopodia
… invadopodia and AC invasion. Using a sensitized genome-wide RNAi screen, classical genetics, and timelapse imaging of invadopodia at the AC-BM interface, Chapter 3 presents two in vivo invadopodia regulators that function by distinct mechanisms. This is the first in vivo evidence that the …
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A New Type of Programmed Cell Death in C. Elegans
… timing pathway in the animal. Conducting a genome-wide RNAi screen, we have identified new candidate regulators of linker cell death. Characterization of these genes may uncover the molecular mechanism driving this new type of programmed cell death in C. elegans. </p>
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A Cell Biological Determination of Integrator Subunit Localization
… of RNAPII. Subsequently, our lab performed a genome-wide RNAi screen that identified two more members of the complex that we have termed IntS13 and IntS14. We have determined that IntS9 and 11 mediate the 3’ cleavage of snRNAs, but the exact function of the other subunits remains unknown. …
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Functional Analysis of Drosophila Integrator Complex In Snrna 3' End Processing
… of the snRNA 3’ end, we performed a functional RNAi screen in <em>Drosophila</em> S2 cells to identify protein factors required for snRNA 3’ end formation. This screen was conducted by using a fluorescence-based reporter that elicits GFP expression in response to a deficiency in snRNA …