Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Genome-wide DNA methylation"”.
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The Human Pancreatic Islet Methylome and Its Role in Type 2 Diabetes
… adverse environmental factors may alter the epigenome, and result in changes of gene expression and the resulting phenotype. The aim of this thesis was to analyze DNA methylation levels of specific genes, as well as genome-wide DNA methylation, in order to determine whether epigenetic …
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Microfluidics for Genetic and Epigenetic Analysis
… of genomic and epigenomic features for a wide range of applications. Microfluidics has been proven to be highly complementary to NGS technology with its unique capabilities for handling small volumes of samples and providing platforms for automation, integration, and multiplexing. In this …
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Diagnostic and prognostic DNA methylation biomarkers of renal clear cell carcinoma /
… current study aimed to develop a gene-specific DNA methylation tool for non-invasive and early kidney cancer diagnosis and follow-up. Genome-wide DNA methylation profiling utilizing microarrays allowed the identification of a set of novel presumable ccRCC-specific DNA methylation biomarkers, …
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Analysing small-sample-sized methylation data to identify biomarkers for congenital heart defects
… modifications, such as Deoxyribonucleic Acid (DNA) methylation, are thought to contribute to the pathogenesis of CHDs. We aimed to investigate the value of machine learning (ML) in enhancing CHDs diagnosis, particularly for identifying susceptive genes by exploring high-throughput DNA …
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Methods and Mechanisms of DNA Methylation in Development and Disease
<p>DNA methylation is a mechanism for long-term transcriptional regulation and is required for normal cellular differentiation. Failure to properly establish or maintain DNA methylation patterns leads to cell dysfunction and diseases such as cancer and neurological disorders. The goal of this …
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Rearrangements of 7q11.23: disorders of the epigenome
… impact of rearrangements at 7q11.23 on the epigenome, I have studied parent-of-origin dependent expression of individual genes at this locus, as well as genome-wide DNA methylation. Here I provide the first evidence to show that rearrangements of 7q11.23 result in dose-dependent changes to DNA …
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Dynamic regulation of DNA demethylation and RNA-directed DNA methylation in Arabidopsis
<p>DNA methylation is an important epigenetic mark present in many eukaryotes, and is involved in many crucial biological processes, such as gene imprinting, regulation of gene expression, and genome stability. Proper genomic DNA methylation patterns are achieved through the concerted action of DNA …
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Microfluidic Technology for Low-Input Epigenomic Analysis
Epigenetic modifications, such as DNA methylation and histone modifications, play important roles in gene expression and regulation, and are highly involved in cellular processes such as stem cell pluripotency/differentiation and tumorigenesis. Chromatin immunoprecipitation (ChIP) is the technique …
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Efficient gene set analysis of high-throughput data : From omics to pathway architecture of health and disease
Background: A wide range of diseases, normal variations in physiology and development of different species are caused by alterations in gene regulation. The study of gene expression is thus crucial for understanding both normal physiology and disease mechanisms. High-throughput mea- surement …
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Epigenetics and sex expression in trioecious papaya
… we analyzed the small non-coding RNAs (sRNA) and DNA methylation in different papaya sex types. Endogenous small RNA molecules of ~18-30 nucleotides play an important role in regulating gene expression and genome defense. Using large scale sequencing reads, we analyzed sRNA biogenesis and function …
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Maintaining Proper Levels of DNA Methylation Marks Through the TET Family is Critical for Normal Embryo Development in Pigs
DNA methylation is one of the principal epigenetic modifications that plays an essential role in transcriptional regulation. After fertilization, mammalian embryos undergo dynamic changes in genome-wide DNA methylation patterns and the changes are essential for normal embryo development. Ten-eleven …