Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1219 for “"Genome-wide"”.
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Genome-wide analyses using bead-based microarrays
… tool for biological research and have a wide range of applications. In this thesis I investigate the BeadArray microarray technology developed by Illumina. The design of this technology is unique and gives rise to many computational and statistical challenges. However, I show how …
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Genome-Wide Decoding of mRNP and miRNA Maps
… limited number of primary transcripts in the genome has promoted interest in the possibility that much of the complexity in the regulation of gene expression may be determined by RNA regulation controlled by RNA-binding proteins (RNABPs) and/or microRNAs (miRNAs). However, applying biochemical …
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Genome-wide microbial phylogeny reconstruction with polytomy identification
… increasing speed of newly sequenced microbial genome deposition, the study of the evolutionary relationships among microbes has becoming more and more imperative. Using complete genome sequences to infer large scale multi-furcating microbial phylogeny without relying on MSA (multiple sequence …
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GENOME-WIDE PROTEIN MOLECULAR ARCHITECTURE OF HUMAN PROMOTERS
… TFs, cofactors, and nucleosomes within the human genome—and their interactions on a genomic scale—has yet to be thoroughly investigated. In this study, we developed an advanced version of the ChIP-exo assay (v6), utilizing a combination of nucleases as high-precision structural probes to …
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Genome-wide association study of persistent developmental stuttering
A genome-wide association study (GWAS) is an approach that involves scanning markers across complete sets of DNA, or genomes, of many people to indentify genetic variations associated with a particular disease. A GWAS uses unrelated individuals, and for the purposes of this study, only those who …
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Deciphering genetic associations using genome-wide epigenomics approaches
… complex human phenotypes and disease through the genome-wide association study (GWAS) has identified thousands of causal genetic loci in the human population. However, genetic mapping approaches can often only reveal a particular causal locus, not the molecular mechanism through which it acts. …
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Genetics of Type 2 Diabetes and Metabolic Syndrome: From Genome Wide Linkage Scan and Candidate Genes to Genome Wide Association Studies
… a region linked to obese T2D in an earlier genome wide linkage study; 2) studied IRS1 as a candidate gene for T2D and MetS and 3) studied the role of 28 genes, earlier identified in candidate gene- and genome wide association studies (GWAS) as susceptibility genes for T2D, in MetS. In study …
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Assessment of Penalized Regression for Genome-wide Association Studies
The data from genome-wide association studies (GWAS) in humans are still predominantly analyzed using single marker association methods. As an alternative to Single Marker Analysis (SMA), all or subsets of markers can be tested simultaneously. This approach requires a form of Penalized Regression …
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Genome wide search for pseudo knotted non-coding RNAs
… replication and RNA modification. Searching genomes using computational methods has become an important asset for prediction and annotation of ncRNAs. To annotate an individual genome for a specific family of ncRNAs, a computational tool is interpreted to scan through the genome and align its …
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Genome-Wide Dynamics of Chromatin Maturation Following DNA Replication
… methods, while informative, lack the genome-wide base-pair resolution required to assess the dynamics of chromatin assembly and maturation in a spatial-temporal manner. To overcome the limitations of these studies, I have taken advantage of an epigenome mapping technique based on …
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Genome-wide association study for sperm motility in pigs
A qualidade do sêmen de reprodutores suínos pode ser avaliada de acordo com vários critérios, sendo a motilidade espermática o mais utilizado e importante. A motilidade, essencial para a fertilização, refere-se ao movimento retilíneo dos espermatozóides. Apesar da importância da avaliação de …
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Leveraging the microbiome in host genome wide association studies
Genome-wide association study (GWAS) has emerged as an effective method for detecting genetic polymorphisms associated with expressed phenotypes. Over the past decade, GWAS of human traits and diseases has revolutionized the field of complex disease genetics, identifying hundreds of genetic …
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Probabilistic framework for genome-wide phylogeny and ortholog determination
… species has emerged as a powerful tool for genome signal discovery. To that end, dozens of mammalian, fly, and fungal genomes have been fully sequenced. Making use of these genomes requires rigorous computational methods for determining the evolutionary history of every gene and region. In …
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Structure and dynamics of genome-wide diversity in Prochlorococcus
… has its foundation in the diversity of microbial genomes. Here we explore adaptation and diversification through the lens of the marine cyanobacterium Prochlorococcus, which comprises a group of closely-related ecotypes that together perform most of the primary production in low-nutrient regions …
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Computational Analysis of Genome-Wide DNA Copy Number Changes
… important form of structural variation in human genome. Somatic copy number alterations (CNAs) can cause over expression of oncogenes and loss of tumor suppressor genes in tumorigenesis. Recent development of SNP array technology has facilitated studies on copy number changes at a genome-wide …
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Identification of Two Novel Genome-Wide Significant Single Nucleotide Polymorphisms, associated with Barrett’s Oesophagus, determined by further Replication of a Genome-Wide Association Study
… to oesophageal adenocarcinoma (EAC). A previous genome-wide association study (GWAS) identified BE susceptibility Single Nucleotide Polymorphisms (SNPs) on chromosome 6p21, within the HLA region, and16q23, where the closest protein-coding gene was FOXF1. The replication study outlined in this …
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Genome-wide association study of muscle traits in Icelandic sheep
… allra gripa. Erfðamengis-tengslagreining (e. genome-wide association study) var framkvæmd annars vegar með BLUP einkunn sem eiginleika og hins vegar með öll sýnin skipt í tvo hópa; valið vöðvafé og óvalið fé sem tilfelli og viðmið (e. case/control). Fáir einbasabreytileikar voru tölfræðilega …
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Genome-Wide Human-Specific RNA Regulatory Elements in the Brain
… technology and the implementation of clinical genome and exome sequencing have allowed for the identification of candidate variants and genes essential in brain development and pathogenesis of neurological diseases, yet there is still much to be learned. It is estimated that the molecular …
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GENOME-WIDE IDENTIFICATION OF RNA SENSORS IN PROKARYOTES AND EUKARYOTES
… and experimentally identifies RNA sensors genome-wide. Applying PARCEL to a collection of prokaryotic and eukaryotic organisms revealed 58 novel RNA sensors. The newly identified RNA sensors exhibit significant sequence and structure conservation, but an unexpected prevalence outside of …
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Phenotype prediction and feature selection in genome-wide association studies
Genome wide association studies (GWAS) search for correlations between single nucleotide polymorphisms (SNPs) in a subject genome and an observed phenotype. GWAS can be used to generate models for predicting phenotype based on genotype, as well as aiding in identification of specific genes …
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