Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Genome scan"”.
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A Genome Scan for Quantitative Trait Loci in Dairy Cattle
A genome scan for quantitative trait loci (QTLs) influencing milk production, health and conformation traits was completed in Holstein-Friesian cattle using a granddaughter design. Eight half-sibling families consisting of 1,068 bulls were genotyped for 174 microsatellite markers. The markers …
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Mapping of monogenic and quantitative trait loci using a whole genome scan approach and single nucleotide polymorphism platforms
The release of the bovine genome sequence in 2004 opened the door for the development of high density single nucleotide polymorphism (SNP) panels that can be used for linkage disequilibrium mapping of traits in cattle populations. The BovineSNP50 Beadchip, containing 54,001 SNP markers, was …
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Gene Discovery In Nonsyndromic Cleft Lip With Or Without Cleft Palate
… genes in normal craniofacial development. Using genome scan and candidate gene approaches, novel associations with NSCLP were identified. These include MYH9 (7 SNPs, 0.009≤p<0.05), Wnt3A (4 SNPs, 0.001≤p≤0.005), Wnt11 (2 SNPs, 0.001≤p≤0.01) and CRISPLD2 (4 SNPs, 0.001≤p<0.05). The most …
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Evolutionary analysis of mammalian genomes and associations to human disease
… pathways causative of species differences. The genome scan analysis spurred an in*depth evolutionary analysis of the nuclear receptors, a family of transcription factors. 12 of the 48 nuclear receptors were found to be under positive selection in mammalia. The androgen receptor was found to have …
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The genetics of atrial septal defect and patent foramen ovale
… extending this heterogeneity, but a whole genome scan did not identify a candidate locus for this disorder. Previous studies of inbred laboratory mice showed an association between patent foramen ovale (PFO) and measures of atrial septal morphology, particularly septum primum length (“flap …
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A linkage study of autism using multipoint sib-pair analysis
… Hospital in Perth, Australia) scanned the entire human genome for autism susceptibility genes in 90 American multiplex families, making this the largest genome screen in autism to date. Candidate regions were also run in an additional group of 41 Australian multiplex families. …
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Clinical and genetical aspects of Celiac Disease
… ered all fi rst-degree relatives of CD patients. Genome-wide linkage scan was performed in the same material. Th is work showed signifi cant evidence of linkage to CD with an interesting region on chromosome 5q31-33 and on chromosome 11q. Simplex CD family material was collected for further …
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miRNAMatcher: High throughput miRNA discovery using regular expressions obtained via a genetic algorithm
In summary there currently exist techniques to discover miRNA however both require many calculations to be performed during the identification limiting their use at a genomic level. Machine learning techniques are currently providing the best results by combining a number of calculated and …
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Identification and characterization of genetic markers and metabolic pathways controlling net feed efficiency in beef cattle.
… model. The interval linkage analysis of whole genome detected six suggestive QTL (BTA 1, 6, 8, 9, 16, and 20) segregating for NFE. Of these 6 QTL, 4 NFE QTL (BTA 1, 6,16, and 20) were homeologous to QTL for NFE observed in fullsib F2 families of mouse selection lines (Fenton 2004). After the …