Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Genome regulation"”.
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Genome regulation by long noncoding RNAs
Our genomes encode the molecular information that gives rise to life, yet we are just beginning to unravel how this information is organized, interpreted, and regulated. While the human genome contains -20,000 protein-coding genes, mammalian genomes also produce thousands of long non-coding RNAs …
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Relationships between chromatin features and genome regulation
Regulation of gene expression is an essential process for all living organisms. Transcriptional regulation, associated with chromatin, is governed by: (1) DNA sequence, which creates regulatory sites (promoters, enhancers and silencers), where sequence motifs and features (e. g. CpG) can attract …
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Dewdrops on the genome : regulation of gene expression by biomolecular phase separation
… DNA-elements (genes) into RNA. Mutations or dysregulation in control of gene expression underlie many diseased states, including cancer and neurodegenerative disorders. Non-coding DNA elements called enhancers orchestrate the complex biochemical pathways that lead to precise activation of …
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Characterizing variation at short tandem repeats and their role in human genome regulation
… motifs of 1-6bp that span over 1% of the human genome. The level of STR variation and its effect on phenotypes remains mostly uncharted, mainly due to the difficulty in accurately genotyping STRs on a large scale. To overcome bioinformatic challenges in STR genotyping, we developed lobSTR, an …
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Insights into the molecular mechanisms of function and regulation of histone crotonylation
… about the molecular machineries involved in the regulation and interpretation of a HPTM is crucial for understanding their functional significance. Histone crotonylation is a well-conserved PTM, structurally similar, but functionally distinct to the well-studied acetylation. Its levels are …
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Using signal processing, evolutionary computation, and machine learning to identify transposable elements in genomes
About half of the human genome consists of transposable elements (TE's), sequences that have many copies of themselves distributed throughout the genome. All genomes, from bacterial to human, contain TE's. TE's affect genome function by either creating proteins directly or affecting genome …
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Investigating DNA G-quadruplex structure function through genome and epigenome engineering
… as four-stranded DNA G-quadruplexes (G4s), in genome function remains a largely unanswered question. G4s are implicated in transcriptional regulation; however, earlier studies are mostly correlative and do not directly address the role of an individual G4 within its endogenous cellular context. …
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Photoprotection and chloroplast regulation in the green algae Chlamydomonas reinhardtii
… possible roles they may be playing in psaA regulation. Together these chapters expand our understating of the role of qE in long term acclimation to saturating and sinusoidal light regimes and provide a library of putative chloroplast regulatory mutants that, with further characterization, …
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Characterising functions of long non-coding RNAs in Drosophila embryogenesis
… has expanded our understanding of eukaryotic genome regulation with the discoveries of functional non-coding ribonucleic acids (RNAs). In recent years, the number of studies in the field of long non-coding RNA (lncRNA) biology has increased dramatically. Transcriptomic analyses of the …
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Genome-wide Footprinting Uncovers Epigenetic Regulatory Paradigms by Revealing the Chromatin Occupancy Landscape
<p><p>Eukaryotic genomes have extensive flexibility and plasticity to modify transcription and replication programs, yielding a myriad of differentiated cell types and survival mechanisms to adverse environmental conditions. As these genomic processes require precise localization of DNA-binding …
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A role for environmental epigenetics in the rapid diversification of East African cichlid fishes
… phenotypic plasticity involves a change in gene regulation. These gene regulatory transitions are commonly mediated by an array of epigenetic mechanisms, which exert dynamic, environmentally responsive control over the genome. In vertebrates, these mechanisms include regulation via histone …