Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Genome function"”.
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Investigating the genomic distribution and potential contribution of retrotransposable elements in relation to their potential impact on genome function and predisposition to human diseases.
… in relation to their potential impact on genome function and predisposition to human diseases. Randa Aweis Ali Active retrotransposable elements (RTEs) provide a continuous source of genomic diversity in humans. The potential impact of a novel RTE insertion depends on its genomic location. …
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Novel Roles for A-Type Lamins in Maintaining Genomic Stability
… insight into how nuclear organization affects genome function and stability and the relationship between nuclear organization, cancer and other age-related diseases. To advance the field, I have investigated the role of A-type lamins in the maintenance of genomic stability in mammalian cells. I …
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The Role of Genomic Sequence in the Spatial and Temporal Propagation of Heterochromatin
… organisms is critical to our understanding of genome function. One means by which patterns of gene expression are achieved is through the differential packaging of DNA into distinct types of chromatin. While chromatin state exerts a major influence on gene expression, the extent to which …
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Statistical methods for testing differential gene expression in bulk and single-cell RNA sequencing data
… the transcriptome enables understanding of the genome function in response to biological or experimental factors, such as disease and development. RNA sequencing (RNA-seq) uses massively parallel sequencing technologies to profile the transcriptome. Among others, the objective of many RNA-seq …
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The role of the PWWP domain in the DNA methyltransferase 3A targeting to the genome
… DNA content but have a distinct appearance and function. This is achieved by activation and repression of genes by epigenetic mechanisms, which are crucial for stable differentiation of cells in a multi-cellular organism. DNA methylation, established by DNA methyltransferase (DNMT) enzymes, …
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Using signal processing, evolutionary computation, and machine learning to identify transposable elements in genomes
About half of the human genome consists of transposable elements (TE's), sequences that have many copies of themselves distributed throughout the genome. All genomes, from bacterial to human, contain TE's. TE's affect genome function by either creating proteins directly or affecting genome …
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Study of 3D Genome Organisation in Budding Yeast by Heterogeneous Polymer Simulations
… the nucleus has revealed the essential role of genome organisation in controlling genome function. Furthermore, genome architecture is highly dynamic and significant chromatin re-organisation occurs in response to environmental changes. However, the mechanisms that drive the 3D organisation of …
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Investigating DNA G-quadruplex structure function through genome and epigenome engineering
… as four-stranded DNA G-quadruplexes (G4s), in genome function remains a largely unanswered question. G4s are implicated in transcriptional regulation; however, earlier studies are mostly correlative and do not directly address the role of an individual G4 within its endogenous cellular context. …
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Simultaneous computational discovery of DNA regulatory motifs and transcription factor binding constraints at high spatial resolution
… from noisy ChIP-Seq data. I first present the genome positioning system (GPS) algorithm which predicts protein-DNA interaction events from ChIP-Seq data using a single-base resolution generative probabilistic model. Using synthetic and actual ChIP-Seq data, I show that GPS improves the …
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"""TSA-Seq"": a novel proximity mapping approach for studying three dimensional genome organization and function"
… 2010) and is important for maintaining normal genome function. However, although it is known that the distribution of chromatin and genes in the eukaryotic cell nucleus is non-random and dynamic, the actual domain organization of chromatin, the mechanisms and dynamics which give rise to this …
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Multiscale Modeling of Genome Organization: Bridging Polymer Physics, Molecular Dynamics, and AI
The human genome is intricately organized within the nucleus, and its spatial arrangement plays a critical role in gene regulation, cellular function, and disease. Recent advances in high- throughput experiments have unveiled the heterogeneous and dynamic nature of chromatin organization at …
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Mechanisms of epiallelic variation in mouse
… elements (TEs) dominate the eukaryotic genome landscape, accounting for half of the mammalian genome. Over evolutionary time, TEs are co-opted by the host and contribute to genome regulatory networks and chromatin architecture. TEs are also the target of elaborate epigenetic regulatory …
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The Nucleosome Remodelling & Deacetylase complex: Genome folding & transcriptional regulation
Genome function is highly dependent on the three dimensional organisation of chromatin within a cell’s nucleus. Approximately 2 metres of DNA is folded to fit within a nucleus which is on the order of a few micrometers. In addition to simply fitting within the space available, this folding directly …