Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Genome diversity"”.
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Genome diversity and evolution in canine transmissible venereal tumour
… and (3) to map the genetic as well as phenotypic diversity of CTVT tumours around the world. To understand the distribution patterns of CTVT, I obtained information from 645 veterinarians and animal health workers in 109 countries, and generated a snapshot of the locations in which this disease is …
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Evolutionary and ecological genomics in deep-sea organisms
… as well as understanding species’ relatedness, diversity, connectivity patterns, and adaptive potential is fundamental for the implementation of conservation strategies that help mitigate these threats. This thesis provides fundamental high-priority knowledge in taxonomic, evolutionary, and …
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Genetic variation and health in a rural Caribbean village
… growth data, cardiometabolic metrics, and genome-wide single nucleotide polymorphism (SNP) data from this population to investigate sources of variation in anthropometric and cardiometabolic outcomes. Mixed effect heritability models indicate that (1) variation in body mass index (BMI) is …
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GENETIC DIVERSITY AND LINKAGE DISEQUILIBRIUM IN WILD SOYBEAN, LANDRACES, ANCESTRAL, AND ELITE SOYBEAN POPULATIONS
… selection can impact populations by reducing genome diversity and increasing the extent of linkage disequilibrium (LD). To understand the impact of these genetic bottlenecks and selection on sequence diversity and LD within soybean [Glycine max (L.) Merr.], 111 genes and three chromosomal …
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Investigating the genetic diversity, population structure and archaic admixture history in worldwide human populations using high-coverage genomes
… present the analysis on 929 high-coverage (>30x) genomes from the Human Genome Diversity Project (HGDP) panel, a collection of cell lines from 54 populations across the world. Some data processing steps were necessary for downstream analysis, including lifting over resources on a different …
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The role of mobile elements in recent primate genomes
… (MEs), which constitute ~50% of the primate genomes, have contributed to both genome evolution and gene function as demonstrated by ample evidence discovered over the last few decades. The three studies in this thesis aims to provide a better understanding of the evolutionary profile and …
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Genomic insights into the human population history of Australia and New Guinea
… I present population-genetic studies using whole-genome sequencing and genotype array datasets from more than 500 indigenous individuals from Australia and New Guinea, as well as initial work on large-scale sequencing of other, worldwide, human populations in the Human Genome Diversity Project …
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Evolutionary and ecological genomics in deep-sea organisms
… as understanding species' relatedness, genetic diversity, connectivity patterns, and adaptive potential is fundamental for the implementation of conservation strategies that help mitigate these threats. This thesis provides fundamental high-priority knowledge in taxonomic, evolutionary, and …
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Insights into the genomic histories of diverse human populations using whole-genome sequencing analysis.
… research is still not fully reflective of the diversity found globally. Understudied populations limit our knowledge of genetic variation and population history, and their inclusion is needed to ensure they benefit from future developments in genomic medicine. In this thesis, I describe …
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Analysis of the genome organization and fitness traits of non-pathogenic Escherichia coli strain Nissle 1917 (O6:K5:H1)
In the last years more than one hundred microbial genomes have been sequenced, many of them from pathogenic bacteria. The availability of this huge amount of sequence data enormously increases our knowledge on the genome structure and plasticity, as well as on the microbial diversity and evolution. …
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The impact of Terminal Inverted Repeat (TIR) transposable elements on plant genomes
<p>As major components in eukaryotic genomes, Transposable Elements (TEs) have been studied for decades. In the 1950s to 1990s, the predominant opinions considered TEs as “junk DNA” and “selfish elements”. However, subsequent studies showed that TEs are important players in genome dynamics. TEs are …
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Single molecule DNA dynamics in micro- and nano-fluidic devices
Rapid genome characterization is one of the grand challenges of genome science today. Although the complete sequences of certain representative human genomes have been determined, genomes from a much larger number of individuals are yet to be studied in order to fully understand genome diversity …
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Streptococcus equi subsp. zooepidemicus in New Zealand horses
… isolates which was resolved by employing core genome MLST. Importantly, none of these typing methods could link a particular strain to disease status or anatomical region. However, when disease occurred the number of colonising strains tended to reduce to just the infective strain, indicating …
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Ancestralidade como fator de risco para hipotireoidismo: estudo da coorte ELSA-BRASIL
Introduction– Genomic ancestry refers to the genetic relationship between an individual and their ancestors, from whom they biologically descend. The self-reported ancestry of the Brazilian population is subject to important genomic divergence and there are sensitive markers capable of stratifying …