Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"Genome Wide Association Study (GWAS)"”.
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Type-1 diabetes risk prediction using multiple kernel learning
… etc. In this thesis, this method was applied for Genome-wide association study (GWAS) for classifying cases and controls. This thesis has shown that combined kernel does not perform better than the individual kernels and that MKL does not select the best model for this problem. Also, the effect of …
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Quantification of sugars and organic acids in 210 cucumber (cucurbis sativus) varieties for genome-wide association studies (GWAS)
… information on the sugar and acid contents in Genome-Wide Association Study (GWAS) cucumbers. This study aimed to measure total soluble solid content (ºBrix), three main sugars via high-performance liquid chromatography (HPLC), pH, titratable acidity (TA), and three main organic acids via HPLC …
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Genome-wide association study of persistent developmental stuttering
A genome-wide association study (GWAS) is an approach that involves scanning markers across complete sets of DNA, or genomes, of many people to indentify genetic variations associated with a particular disease. A GWAS uses unrelated individuals, and for the purposes of this study, only those who …
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Risk prediction with genomic data
Genome wide association study (GWAS) is widely used with various machine learning algorithms to predict disease risk. This thesis investigates this widely used approach of GWAS using Single Nucleotide Polymorphism (SNP) genotype data and a novel approach of disease risk prediction with whole exome …
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Linkage fine-mapping, GWAS and QTLs affecting morpho-agronomic traits of a common bean RIL population
… of the most cultivated and consumed legumes worldwide. It is a relatively inexpensive source of protein and nutrients, establishing itself as an important food in maintaining food security on the world. In this sense, genetic breeding is essential to obtain more productive cultivars, with plant …
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A genome-wide association study in chronic thromboembolic pulmonary hypertension and the ADAMTS13-VWF axis
… might allow risk-stratification following PE. A genome-wide association study (GWAS) was performed in 1250 CTEPH patients, 1492 healthy controls and ~7 million single-nucleotide polymorphisms to identify novel disease loci. The ABO locus was identified as the most significant common variant …
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Fzd6, Matn2 and Slc25A32, Possible Candidate Genes In Nonsyndromic Cleft Lip and Palate
… of NSCLP still remain largely unexplained. A genome wide association study (GWAS) of a large NSCLP African American family with seven affected individuals across three generations found evidence for linkage at 8q21.3-24.12 (LOD = 2.98). This region contained three biologically relevant …
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High Precision Binary Trait Association on PhylogeneticTrees
… resistance, and host adaptation. Traditional genome-wide association study (GWAS) methods fail to account for shared evolutionary history, confounding association analyses. Microbial GWAS approaches emerged to address this, but modern methods often lack the statistical power to detect …
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Deciphering genetic associations using genome-wide epigenomics approaches
… complex human phenotypes and disease through the genome-wide association study (GWAS) has identified thousands of causal genetic loci in the human population. However, genetic mapping approaches can often only reveal a particular causal locus, not the molecular mechanism through which it acts. …
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Enhancing Seed Quality and Application of Soybean through High Test Weigh and Low Trypsin Inhibitors
… associated with high test weight through a genome-wide association study (GWAS) as well as determine the relationship between important seed composition traits and test weight. Additionally, it focused on identifying and knocking out KTI genes specifically expressed in soybean seed tissue …
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Assessing and Implementing Value-Added Soybean Innovations in the Soybean Meal and Food Industry
… protein digestion in monogastric animals. This study employed a multifaceted approach combining phenotyping, genome editing, and association mapping to enhance soybean quality. First, we developed near-infrared reflectance spectroscopy (NIR) calibration models for the rapid estimation of total …
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Identification of QTL and candidate genes for plant density tolerance in maize
… the nine subpopulations revealed 246 QTL and genome wide association study (GWAS) identified 11 single nucleotide polymorphisms (SNPs) with significant trait associations. Positional and functional candidate genes were investigated and are discussed.
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Integrating Genomic and Phenomic Breeding Selection Tools with Field Practices to Improve Seed Composition Quality Traits in Soybean
Despite soybean's widespread recognition as a versatile and valuable crop due to many end-use purposes, breeders seek to develop varieties with improved nutritional and functional components that capture added-value for producers. Additionally, producers seek to maximize profits by utilizing field …
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Efeito do cromossomo x no mapeamento de regiões genômicas sobre características de interesse econômico em búfalos da raça murrah
… is the fifth largest chromosome in the buffalo genome, containing many genes that can influence the expression of economically important traits. However, in current GWAS studies, researchers almost exclusively use molecular markers from autosomes, excluding the sex chromosomes. Thus, the aim of …
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Evaluation of genomic prediction models that incorporates peak GWAS signals in maize and sorghum diversity panels
… The statistical models typically used in a genome-wide association study (GWAS) and genomic selection (GS) quantify the contributions of genomic markers in linkage disequilibrium with these genes to trait variation. In general, the GWAS has been successful at identifying genomic regions …
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Genome-wide association study of Barley Yellow Dwarf Virus resistance in a Nested Association Mapping population of winter wheat using Skim Exome Capture and Practical Haplotype Graph imputation
… remains the most sustainable approach. In this study, a genome-wide association study (GWAS) was conducted to identify loci associated with BYDV resistance in a Nested Association Mapping (NAM) population of winter wheat derived from ‘Overland’. Phenotypic evaluations were conducted under …
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Identification of Two Novel Genome-Wide Significant Single Nucleotide Polymorphisms, associated with Barrett’s Oesophagus, determined by further Replication of a Genome-Wide Association Study
… to oesophageal adenocarcinoma (EAC). A previous genome-wide association study (GWAS) identified BE susceptibility Single Nucleotide Polymorphisms (SNPs) on chromosome 6p21, within the HLA region, and16q23, where the closest protein-coding gene was FOXF1. The replication study outlined in this …
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Multi-omics Investigation into Alzheimer's Disease: Functional Mechanism and Early Detection
… Multi-omics integration allows us to explore a wide spectrum of AD-related changes at different biological levels including genomics and metabolomics and how they associate with the biomarkers. In the first aim, I performed an integrative analysis of summary statistics from genome-wide …
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Mapping PAMP Responses and Disease Resistance in Brassicas
… RNA sequencing analysis produced a genome-wide survey of transcriptional changes upon PAMP treatment seen in both the A and C genomes of the allotetraploid B. napus. Using these assays substantial variation in PAMP-responsiveness was observed amongst elite varieties of B. napus. …
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Computational methods for inferring regulatory mechanisms from sequence and expression variation
… variants. Despite the large number of associations been detected, we are not even close to a complete understanding of the mechanisms how the genetic variants contribute to phenotypic variation. With the vast majority of the genetic variants from Genome-wide Association Study (GWAS) …
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