Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 56 for “"Genome Evolution"”.
-
Chromosome and Genome Evolution in Culicinae Mosquitoes
… and Rift Valley fevers. Developing high-quality genome assembly for mosquitoes, studying their population structure, and evolution can help to facilitate the development of new strategies for vector control. Studies on Aedes albopitcus as well as on species from the Culex pipiens complex, which …
-
The persistence of haploinsufficiency and its role in genome evolution
… to humans. Why haploinsufficiency persists over evolutionary time is not known. To answer this, I systematically tested two existing models of haploinsufficiency: 1) the dosage stabilizing hypothesis, which states that haploinsufficiency is caused by imbalances among protein complex members, and …
-
A tale of two clades: genome evolution of oomycetes and fungi.
… are only very-distantly related in terms of evolutionary history. The oomycetes are underresearched in evolutionary science, despite their historical and contemporary impact on food and environmental security. In contrast, fungi themselves are probably the most densely studied and sequenced …
-
Plastid Genome Evolution in the Parasitic Genera Cuscuta (Convolvulaceae) and Krameria (Krameriaceae)
… This is particularly true for plastid genomes (plastomes) given that chloroplasts are the primary site of photosynthesis in the cell and that plastomes encode key portions of the photosynthetic apparatus.In only a handful of embryophyte lineages, however, a heterotrophic lifestyle has …
-
Microbial Genome Evolution Due to Multifaceted Symbiosis within the Tsetse Fly (Diptera: Glossinidae)
… objective of this research is to gain insight on genome evolution resulting from symbiosis, particularly by examining bacteria with varying levels of host dependency and times of establishment. The tsetse fly (Diptera: Glossinidae) serves as a relatively simple model system to investigate …
-
Synthetic biology tools for sensing and evolving microbes: CRISPR-diagnostics and transposon-mediated genome re-wiring
… (MGEs) have played a fundamental role in the evolution of complex organisms, driving innovation through competition, collaboration and co-option. Transposons, in particular, are an ancient family of MGEs whose diverse functions have provided a rich source of DNA-binding and nuclease domains …
-
Ancestral Genome Reconstruction in Bacteria
The rapid accumulation of numerous sequenced genomes has provided a golden opportunity for ancestral state reconstruction studies, especially in the whole genome reconstruction area. However, most ancestral genome reconstruction methods developed so far only focus on gene or replicon sequences …
-
Decoding The Evolutionary Response to Prostate Cancer Therapy Using Plasma Genome Sequencing
<p>Investigating genome evolution in response to therapy is difficult in human tissue samples due to the difficulty in accessing metastatic tumor sites and logistical challenges of collecting longitudinal samples. To overcome these issues, we developed an unbiased whole-genome plasma DNA sequencing …
-
The identification and characterization of inter- and intra-species genetic diversity derived from retrotransposons in humans
… have begun to reveal their immense value to genome evolution and human biology due to recent studies. They consist of at least ~45% of the human genome and are more or less the same in other mammalian genomes. Retrotransposon elements (REs) are known to affect the human genome through many …
-
The identification of novel factors required for the development of primordial germ cells
… next generation. These mutations not only drive genome evolution but can also impair the fitness of the offspring. It has been shown that primordial germ cells (PGCs), the germ cells specified during embryonic development, have the highest mutation frequency compared to germ cells belonging to …
-
Analysis of the relationship between genomic instability, heterozygosity levels and phenotype in Saccharomyces cerevisiae
Understanding the forces that mediate genome evolution is a central problem in genetics, with implications for diverse processes that range from speciation, to biotechnological applications, to human disease. The central theme of my dissertation was the characterization of two forces, genomic …
-
Complex evolution of mitochondrial genomes: lessons from salamanders
This dissertation research on genome evolution focuses on understanding the mechanisms that drive the evolution of mitochondrial genome size, content, and organization in animals. This research uses a combination of empirical and computational approaches to examine the evolution of mitochondrial …
-
Statistical analysis of short template switch mutations in human genomes
Many complex rearrangements arise in human genomes through template switch mutations, which occur during DNA replication when there is a transient polymerase switch to an alternate template nearby in three-dimensional space. These variants are routinely captured at kilobase-to-megabase scales in …
-
An RNA-interference-based platform for genome analysis and engineering in Saccharomyces cerevisiae
… tasks prove to be better fulfilled with directed evolution than with rational design, by performing iterative cycles of mutagenesis and selection. However, the success of directed evolution is mostly confined to individual proteins, due to the lack of efficient tools to introduce mutations …
-
Evolutionary Analysis of Large-Scale Genomic Changes
… differences in gene order among species. In the genomes, genes are rearranged through inversion, transposition, translocation, and chromosome fission and fusion. Using gene order as a phylogenetic character has the potential to resolve previously unresolved species relationships. In this study, …
-
Mechanisms and impact of alternative transposition-induced segmental duplications
… are prevalent in both plant and animal genomes, and have played important roles in genome evolution. The focus of my project is to understand the transposition-mediated mechanisms that lead to the formation of segmental duplications, and the immediate impact of recently generated large …
-
Helitrons are enriched in lichenized fungi with long generation length and small distribution sizes
… elements (MGEs) have the potential to drive genome evolution by introducing mutations and causing structural instability and chromosomal rearrangements, particularly under conditions like environmental or genetic stress. In this study, we generated 18 new long-read reference genomes for …
Page 1 of 3