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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 66 for “"Genome Analysis"”.
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Functional Genome Analysis of Mycobacterium tuberculosis
Anhand filterbasierter DNA-Arrays, die sämtliche offenen Leseraster von Mycobacterium tuberculosis repräsentieren, wurde eine funktionelle Genom-Analyse des Erregers der Tuberkulose durch geführt. Ein Genom-Vergleich von Mitgliedern des M. tuberculosis-Komplexes wies zusätzlich zu den bekannten …
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Comparative microbial genome analysis of lactobacilli
… the functional and phylogenomic diversity of 42 genomes of strains of L. salivarius. We found that multiple phylogenomic and non-phylogenomic methods used for reconstructing trees all converge on similar tree topologies, showing that different metrics largely agree on the evolutionary history of …
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Variation-aware algorithms for cancer genome analysis
… variation-aware algorithms for analyzing cancer genomes. The scientific community has extensively catalogued millions of mutations present in cancer cells. This information is rarely used during read alignment and variant calling because of a lack of algorithms for doing so. Rediscovering these …
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Comparative genome analysis of human bifidobacteria with commercial potential
… two newly sequenced B. longum subsp. longum genomes and subsequent comparative analysis with publicly available B. longum subsp. longum, B. longum subsp. infantis and B. longum subsp. suis genomes (Chapter 2). The acquired data revealed a closed pan-genome for this bifidobacterial species and …
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Genome Analysis of the Ashanti Dwarf pig of Ghana
… Dwarf pig populations. Population cluster analysis performed in this study also suggests that although the African pigs (Ashanti Dwarf pig and Busia pigs) clustered close to European pigs, they may be distinct populations. Also, the candidate genes identified to be associated especially …
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An RNA-interference-based platform for genome analysis and engineering in Saccharomyces cerevisiae
… mutations globally and iteratively on a genome scale. Thanks to its simplicity and effectiveness, the pooled RNA interference (RNAi) screening should satisfy the requirement of directed genome evolution. The RNAi pathway is absent in Saccharomyces cerevisiae, also known as the baker’s …
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Genome analysis of Campylobacter concisus strains from patients with inflammatory bowel disease and gastroenteritis
… amplified fragment length polymorphism (AFLP), analysis of housekeeping genes and 23S rRNA gene. A number of studies have reported C. concisus strains of GS2 to invade human epithelial cell line Caco2, and suggested that C. concisus strains of the two genomospecies may have different virulence …
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Comparative genome analysis of strains of clostridium scindens: A bile acid and cortisol metabolizing gut bacterium
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-02-04 without embargo terms
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Comparative Genome Analysis of Three Brucella spp. and a Data Model for Automated Multiple Genome Comparison
Comparative analysis of multiple genomes presents many challenges ranging from management of information about thousands of local similarities to definition of features by combination of evidence from multiple analyses and experiments. This research represents the development stage of a …
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BIOCONTROL OF ROOT ROT COMPLEX IN FIELD PEA AND LENTIL AND COMPLETE GENOME ANALYSIS OF BIOCONTROL BACTERIA
… chamber conditions, and the strains’ whole genomes were sequenced, annotated, and comparatively analyzed using bioinformatics tools. Also, laboratory-based general functional experiments, siderophores production, proteolytic and cellulolytic capacities, and desiccation tolerance were …
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Systematic Kaposi-Sarcoma Herpesvirus (KSHV) genome analysis from a South African HIV- and KSHV-positive patient cohort
… by the highly variable K1 region of the KSHV genome. Sequencing and characterizing the circulating subtypes in a specific geographical region assist in tracking evolutionary changes as well as malignant outcomes associated with different subtypes. The aim of this study was to determine the …
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Whole Genome Analysis of Escherichia coli and Pseudomonas aeruginosa Mixed Culture Biofilms Grown for 117 Days in Spaceflight
… isolates were chosen to undergo whole genome sequencing to be compared to the ancestral strain genomes. Illumina and Nanopore reads were used obtain draft genomes via a hybrid assembly. Whole genome alignment was used to identify differences, including SNPs, amongst the spaceflight …
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Next-generation sequencing and genome analysis in dimorphic fungi and human: using genomic variation to recognize and understand disease
… bioinformatics, comparative genomics of fungal genomes and clinical genomics of human chronic disease. We primarily focused on using genomic data of dimorphic fungal pathogens in order to obtain a better perspective and understanding of how commonly used assembly, annotation and genomic …
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Genome analysis: mutation analysis using near infrared laser-induced fluorescence (NIR-LIF) and single molecule detection in microfluidic devices
… methods have been developed for mutation analysis, each of which has its own unique advantage. DNA amplification via polymerase chain reaction (PCR) provides an unlimited supply of material for subsequent genetic analysis even in case where only a single copy of the DNA molecule is present …
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Whole genome analysis of the koa wilt pathogen (Fusarium oxysporum f. sp. koae) and development of molecular tools for early detection and monitoring
… that could be used to distinguish pathogenicity. Genome sizes were comparable at 48Mb and 50Mb, respectfully. Fo koae 44 and Fo 170 shared an average nucleotide identity of 96%. Eleven syntenic putative core chromosomes and one unique putative lineage-specific chromosome were identified when …
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Data-Intensive Biocomputing in the Cloud
… made it possible to rapidly sequence the human genome, heralding a new era of health-care innovations based on personalized genetic information. However, these NGS technologies generate data at a rate that far outstrips Moore\'s Law. As a consequence, analyzing this exponentially increasing data …
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GPU acceleration of advanced K-mer counting for computational genomics
… goal is to reduce the overall runtime of many genome analysis tasks that use k-mer counting as an essential step. We achieved 4.03x speedup using one GTX 1080 Ti with one CPU (Xeon E5-2603) thread and 5.88x speedup using one GPU with four CPU threads over KMC2 running on a single CPU thread. …
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Characterization of inducible antibiotic production by streptomycetes isolated from hyper-arid environments
… project employed bioactivity assays, whole-genome analysis and metabolomics to determine the antibiotic potential from bioassays, identification of potential biosynthetic gene clusters and the elucidation of the compounds(s) responsible for the activity. Fourteen strains, closely related to …
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DIRECT REPEATS AND DELETIONS IN MITOCHONDRIAL DNA: CASUAL AND EVOLUTIONARY ASPECTS
… I employed a computational approach using genome analysis and statistical and thermodynamics-based modeling to understand the role of sequence motifs and DNA misalignments in mitochondrial DNA (mtDNA) deletion mutagenesis. Meta-analysis of age-related deletion breakpoints indicated that in …
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