Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 67 for “"Genital Tract"”.
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Studies on immunity in the male genital tract
The male genital tract is a major site of HIV acquisition and transmission. It is an obvious site for inducing immune responses to candidate HIV vaccines, to prevent infection or halt the spread of the virus. There are relatively few published studies characterising T cells in the male genital …
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The distribution of plasminogen activator in the male genital tract
The blood of man is rich in plasminogen, the inactive precursor of plasmin, a protease (Astrup, 1956a); the most characteristic action of plasmin is the digestion of fibrin, i.e. fibrinolysis. Many tissues, including the prostate (Rasmussen and Albrechtsen, 1960a), contain substances which can …
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Determinants of Upper Genital Tract Complications in a Chlamydial Urogenital Mouse Model
<p>Genital Chlamydia trachomatis infection is a major public health concern. Chlamydia is the most commonly reported infection in the United States and the most common bacterial sexually transmitted infection worldwide. Unrecognized infection endangers female reproductive health by serious …
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Vaginal microbial diversity of the genital tract of South African adolescent females
… in Cape Town, South Africa. Bacterial DNA was extracted from lateral vaginal wall swabs using the MoBio Powersoil® DNA Isolation Kit after enzymatic digestion. Positive bacterial reference strains were cultured in MRS buffer and Schwedler's broth, after which the DNA was extracted using the …
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Impact of the mycobiome on the health of the female genital tract
The female genital tract microbiome comprises a community of microorganisms. Imbalances in the microbiome are associated with vaginal diseases such as bacterial vaginosis (BV) and sexually transmitted infections (STIs). These diseases greatly burden South Africa, and young women in this region are …
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Characterizing various aspects of the male genital tract barrier function and immunity
… Understanding the immune milieu in the male genital tract may reveal additional HIV susceptibility mechanisms and factors that can be used as a foundation for alternative HIV preventative strategies. This PhD thesis examines barrier function, the density of HIV target cells and various …
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Gene expression patterns of the female genital tract and immunomodulation by Lactobacillus species
Inflammation in the female genital tract (FGT) is associated with increased HIV-1 viral replication, HIV-1 transmission and HIV-1 acquisition. The optimal commensal Lactobacillus bacterial species is associated with reduced inflammation in the FGT and dampened immune responses to non-optimal …
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Effects of hormonal contraceptives on the female genital tract microbiota in South African adolescents
… affect HIV-1 risk through changes in the female genital tract (FGT) microbiota. We examined the impact of three different HC methods on the adolescent female genital tract microbiota and related cytokine and HIV target cell levels at the cervical mucosa in a randomized, crossover trial. Study …
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Distribution of Chloramphenicol in the Bovine Genital Tract and Pharmacokinetic Studies of Florfenicol in Cattle
… of chloramphenicol (CAP) in the bovine genital tract and to conduct preliminary pharmacologic studies with florfenicol (FLO), a fluorinated analogue of thiamphenicol, in cattle.
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Molecular characterization of mycoplasmas species isolated from the genital tract of Dorper sheep in South Africa
… six out of 34 are 99 % similar to M. bovigenitalium, and two out of 34 were found to be 99 % similar to M. sp. ovine/caprine serogroup II. Two isolates out of 34 are 99 % similar to A. Laidlawii, and BLAST searches of two isolates gave 99 % similarity to M. sp. USP120. Two isolates were …
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Impact of long-acting contraceptives on female genital tract cytokine profiles in a randomised controlled trial
The Evidence for Contraceptive Options and HIV Outcomes (ECHO) trial found no substantial difference in HIV acquisition risk between women randomised to injectable depot medroxyprogesterone acetate (DMPA-IM), copper intrauterine device (IUD) or the levonorgestrel (LNG) implant. However, it remains …
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Male genital tract versus blood HIV-1 compartmentalization and selection: the first step of the transmission bottleneck?
… between these two populations: HIV-1 from the genital tract of the donors: where viruses are on their way to transmission to a new recipient. Importantly, numerous prior studies have shown that there is compartmentalization of HIV-1 populations between the general circulation and the genital …
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Impact of HIV infection on the frequency and phenotype of Th17 cells in the female genital tract
… activation. The role of Th17 cells in regulating genital mucosal immunity during HIV infection is less well described. The aims of this study were (1) to compare the frequency and phenotype of Th17 cells in the female genital tract and blood in uninfected compared to HIV-infected women; and (2) to …
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Functional changes in the ovary and genital tract, as estimated by the appearance of ovarian eosinophilic granulated cells
Thesis (M.S.)--Michigan State University. Dept. of Physiology, 1966
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Role of HAART in reconstituting T-cell function and HIV inhibitory activity in the female genital tract during chronic HIV infection
Includes abstract. Includes bibliographical references.
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Differential effects of combinations of anti-retrovirals and progestins on gene expression and HIV-1 replication in cells of the female genital tract
… ARVs and hormonal contraceptives in the female genital tract. The mucosal surface in the female genital tract is the initial site of HIV entry and viral replication. Understanding the effect of hormonal contraceptives and ARVs is relevant to the potential safety of these for long term use. The …
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The impact of sexually transmitted infections and inflammation in the female genital tract and blood on susceptibility to HIV-1 infection and disease progression
… that pro-inflammatory cytokine production in the genital tract is necessary for immune cell recruitment and establishment of simian immunodeficiency virus (SIV) infection following vaginal inoculation. The aims of this study were to evaluate the relationships between inflammation in the female …
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HIV pathogenesis in the female genital tract during chronic HIV infection : the impact of inflammation, T cell memory differentiation status and homeostatic cytokines on mucosal T cell immunity
The female genital tract serves as the major portal of entry for human immunodeficiency virus (HIV). Local immune factors unique to the mucosal micro-environment such as the genital tract cytokine milieu or the activation/differentiation status of T cells may play a significant role in heterosexual …
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Co-occurrence of shedding Herpes Simplex Virus type-2 (HSV-2), Human Papilloma Virus (HPV) and Human Immunodeficiency Virus 1 (HIV-1) in the female genital tract among HIV-infected women
… show the presence of other viral STI in the genital region may have increased HIV shedding in the genital region. However, it not clearly known if the presence of ART or HIV may affect the shedding of other viral STI in the genital region and if the combination of other viral STI treatment …
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