Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 86 for “"Genistein"”.
-
Estrogenic Effects of Genistein in Ovariectomized Gilts
Genistein, has a range of estrogenic actions, however only limited research has been done to investigate its effects in swine. The objective was to characterize the effects of administration of a graded dose of genistein on tissues known to be estrogen sensitive. Thirty-four post-pubertal gilts …
-
The anti-diabetic mechanisms by isoflavone genistein
… to prevent and treat the onset of diabetes. Genistein, a flavonoid in legumes and some herbal medicines, has various biological actions. It was recently shown that dietary intake of foods containing genistein improves diabetes in both experimental animals and humans. However, the potential …
-
Genistein suppresses colon cancer metastasis through epigenetic regulations
… development and progression of colon cancer. Genistein, one of the major phytochemicals in soy, has been shown to suppress metastasis in different cancer types including colon cancer. Moreover, studies have indicated that genistein is a mediator of epigenetic regulations, including DNA …
-
The effect of dietary genistein on breast cancer metastasis
… the role of the main soy isoflavone, genistein, on the metastasis of 4T1 murine BC cells implanted in ovariectomized (OVX) BALB/c mice (OVX mice mimic the postmenopausal age group). I hypothesized that weakly estrogenic genistein will enhance BC metastasis based on our previous …
-
The Soy Isoflavone, Genistein, as a Modulator of Intestinal Development
In summary, genistein at concentrations currently present in soy infant formulas inhibited intestinal cell proliferation both in vitro and in vivo, which may have implications for the intestinal health of infants and requires further investigation.
-
Improving CNS Delivery of Genistein for the Treatment of Sanfilippo Syndrome
… therapy is available for treating MPS III. Genistein, a dietary soy isoflavone, has been observed to effectively reduce the production and reduce or prevent further accumulation of heparan sulfate in lysosomes in vitro as well as in vivo. However, in vivo reduction of heparan sulfate was …
-
The Effect of Dietary Genistein on Breast Cancer Treatment and Metastasis
… study, we demonstrated that low dose dietary genistein negated the inhibitory effect of tamoxifen on mammary tumor growth. Although high dose genistein did not show the same effect, high tumor prevalence was observed. In the second study, dietary genistein was shown to promote breast cancer …
-
The effects of adult exposure to genistein on female reproductive outcomes
Genistein is a phytoestrogen commonly found in plants such as soybeans, lentils, and chickpeas. Humans and animals are most primarily exposed to genistein through the consumption soy and soy-based dietary products. Human exposure to genistein varies based on diet, but is present in many populations …
-
Mechanism of genistein in the regulation of pancreatic beta-cell proliferation
This study was designed to examine the effect of genistein, a botanical derived primarily from legumes, on pancreatic β-cell proliferation and the related molecular mechanisms. Diabetes mellitus is a major and growing public health problem worldwide. Both in type 1 (T1D) and type 2 diabetes (T2D), …
-
Investigation of the Effects of Genistein and Fenretinide on Ovarian Cancer Cells
The effects of the fenretinide and genistein as single or combined drugs on ovarian cancer proliferation and viability were investigated. Hypothesis: Co-treatment with genistein will enable a lower dose of fenretinide to be effective in inhibiting the proliferation and survival of ovarian cancer …
-
The Phytoestrogen Genistein Induces Thymic and Immune Changes: A Human Health Concern
… estrogenic effects of the soy isoflavones genistein and daidzein. Here we show that subcutaneous genistein injections in ovariectomized adult mice produced dose-responsive decreases in thymic weight of up to 80%. Genistein's thymic effects occurred through both estrogen receptor (ER) and …
-
Epigenetic modifications on WNT genes by dietary genistein during colon cancer development
… is that East Asians consume more soy products. Genistein, a soy-derived isoflavone has been shown to act as an epigenome modifier, and to have anti-cancer properties. We aimed to explore the role(s) of soy isoflavone genistein during the development of colon cancer. Using a human colon cancer …
-
Entwurf und Verwendung eines Microarrays zur Untersuchung des Genistein-Stimulons bei Bradyrhizobium japonicum
… In B. japonicum induziert das Flavonoid Genistein die Transkription einer Reihe von Genen. Durch die Expression der nod-Gene erfolgt eine Synthese von Lipochitooligosacchariden. Diese sogenannten Nodulationsfaktoren rufen wiederum eine Reaktion in der Wirtspflanze hervor. Um die zugrunde …
-
Analyse molekularer Mechanismen der ERα- und ERβ-vermittelten Wirkung spezifischer Liganden und des Phytoestrogens Genistein
… gewebespezifische Einflüsse des Phytoestrogens Genistein (Gen) näher charakterisiert werden. Es konnte gezeigt werden, dass nach einer subkutanen Applikation der knochenprotektive Einfluss von Gen mit dem von Estradiol (E2) vergleichbar ist, durch die Kombination mit Bewegung verstärkt wird und …
-
Genistein-Induced Potentiation Effect on Glucose-Stimulated Insulin Secretion (GSIS) in INS-1 β-cells
… to beta cells under long-term exposure. Genistein, a isoflavonoid phytoestrogen isolated from soy bean seed and having tyrosin kinase inhibition activity, had a potentiation effect on GSIS (glucose-stimulated insulin secretion) in pancreatic INS-1 beta cells. Although the potentiation …
-
Einfluss von Estradiol, Genistein, Equol und Resveratrol auf verschiedene östrogensensitive Organe und Parameter der ovariektomierten Maus
… Um eine Aussage über die Effekte von Estradiol, Genistein, Equol und Resveratrol an den untersuchten, Östrogen-sensitiven Organen und Parametern bei Applikation über mehrere Zyklen treffen zu können, wurde in dieser Studie der Modus des Langzeitversuchs über drei Monate gewählt. Zudem wurd! en …
-
The Interaction of Equol and Genistein on Estrogen Dependent Tumors and Bones in Ovariectomized Athymic Nude Mice
… of the metabolites of daidzein, with and without genistein on human estrogen dependent tumor growth and bone development in ovariectomized athymic nude mice. In the first study, the experiments were conducted to evaluate the effect of equol alone on the T47D human breast cancer cells and bone …
-
Estrogen Inducible Serpin, Proteinase Inhibitor 9, in Immunosurveillance and Apoptosis
The phytoestrogen genistein has attracted a great deal of recent interest. In MCF-7 cells, we find that 10 nM genistein induces PI-9 as effectively as saturating E2, and genistein treated MCF-7 cells are resistant to NK cell mediated cytotoxicity. In ERalphaHA cells, the dose response curves for …
-
Mechanisms of soy isoflavones in the regulation of vascular function
… effort to decrease the burden of CVD morbidity. Genistein, a major soy isoflavone, may be one of those alternative agents because of its selective affinity to estrogen receptor-beta and various beneficial effects on CVD. However, the mechanism of the cardioprotective effects of genistein is still …
-
Die therapeutischen Effekte von Estradiol, Dihydrotestosteron, Genistein und Equol auf den osteoporotischen Knochen der orchidektomierten männlichen Sprague-Dawley-Ratte
… Dihydrotestosteron und den Isoflavonen Genistein und Equol auf den osteoporotischen Knochen untersucht. Als Tiermodell für die Untersuchung der Osteoporose des Mannes kamen 150 männliche, orchidektomierte Sprague-Dawley-Ratten zum Einsatz. Erstmalig wurde in dieser Arbeit die …
Page 1 of 5