Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 204 for “"Genetics and Genomics"”.
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Statistical methods for genetics and genomics studies
Genomics study: the data quality from microarray analysis is highly dependent on RNA quality. Because of the lability of RNA, steps involved in tissue sampling, RNA purification, and RNA storage are known to potentially lead to the degradation of RNAs, therefore, assessment of RNA quality is …
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Genetics and genomics in nursing.: What are the characteristics of genetic nurse adopters and nurse opinion leaders in genetics and genomics?
Background. Aspects of genetics/genomics are increasingly being incorporated into medicine. Nurses are crucial in helping transform healthcare through genomic nursing (Loud, 2010). However the integration of genetics/genomics into nursing education has been sporadic (Dodson and Lewallen, 2011). …
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Physiology, genetics and genomics of drought adaptation in Populus
As the demand for energy rises, Populus species are increasingly grown as bioenergy crops. Meanwhile, due to global change, predictions indicate that summer droughts will increase in frequency and intensity over Europe. This study was carried out to evaluate the adaptation to drought in Populus, at …
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Evolutionary genetics and genomics of flower colour loci in an Antirrhinum hybrid zone
… of reproductive isolation is crucial to understanding the maintenance of diversity between populations. In hybrid zones, loci that establish a barrier to gene flow between populations remain divergent, whereas neutral unlinked loci become mixed. In those instances, fit allelic combinations …
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Needs Analysis of Genetics and Genomics in Communication Sciences and Its Disorders: Evidence for Change
… of the Human Genome Project in 2003, rapid and escalating discovery in genome science has initiated a paradigm shift in education training and healthcare practices. This shift has required healthcare educators and professionals to possess a level of genetic and genomic literacy and …
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Genetics and genomics studies of rice disease resistance and development of alternative disease management methods for bacterial panicle blight and sheath blight
Bacterial panicle blight (BPB) and sheath blight (SB), caused by the bacteria Burkholderia glumae and B. gladioli, and the fungus Rhizoctonia solani, respectively, are two major rice diseases in southern rice growing regions of US. No completely resistant rice cultivars have been identified for …
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Content Analysis of Consent Forms for Clinical Whole Exome Sequencing
… including whether to seek secondary findings and which results will be returned to the patient. The goal of the current study was to explore variation among existing informed consent forms for clinical whole exome sequencing (WES) in order to identify the level of consistency with the …
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Bayesian Kernel Models for Statistical Genetics and Cancer Genomics
… the utility of kernel regression ap- proaches and variance component models for solving complex problems in statistical genetics and molecular biology. Many of these types of statistical methods have been developed specifically to be applied to solve similar biological problems. For example, …
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Molecular Basis of Pathogenesis and Host Determination in Cercospora sojina: from Phenotypic to Genotypic Patterns
… caused by Cercospora sojina, is an important and recurrent disease of soybean in many production regions. Genetic resistance is potentially one of the most cost-effective and sustainable strategies to control FLS. However, C. sojina has already demonstrated the ability to overcome resistance …
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Novel Statistical Methods for Multiple-variant Genetic Association Studies with Related Individuals
… variants. Due to linkage disequilibrium (LD) and familial relatedness, the genotype data from such studies often carries complex correlations. Moreover, missing values in genotype usually lead to loss of power in genetic association tests. Also, repeated measurements of phenotype and dynamic …
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Leveraging Whole Genome Sequences to Compare Mutational Mechanism and Identify Medically Relevant Variation in African versus Non-African Descend Populations
… (WGS) is ushering a new era in healthcare and research in identifying genetic variation in all populations. However, the African populations are still under-represented. Since African populations are being the most genetically diverse with high heterogeneity rate, we need to benchmark the …
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Mechanistic and Epigenetic Partitioning of Lamina-Associated Chromatin Revealed by a Genome-Wide Imaging Screen
… a crucial role in transcriptional repression and genome stability. However, the molecular mechanisms that tether LADs in human cells remain poorly defined. To address this gap, I conducted the first genome-wide, imaging-based siRNA screen to identify regulators of LAD positioning using HiDRO …
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Improving Genetic Analysis with Augmented Experimental Designs
… analysis may increase the residual variance and results in biased estimation of genetic effects. This research addressed this problem by extending the genetic models with augmented experimental designs. Without losing the focus, two extended genetic models were proposed: generalized lattice …
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Regulation Of Acute Myeloid Leukemia Cell Proliferation By E3 Ubiquitin Ligase DCAF15 Control Of Cohesin Dynamics
… to neo-substrate recruitment, ubiquitination, and proteasomal degradation. However, the physiological function of DCAF15 remains unknown. Using a domain-focused genetic screening approach, we reveal DCAF15 as an acute myeloid leukemia (AML)-biased dependency. Loss of DCAF15 results in …
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Population and migratory dynamics of blacklegged ticks and the Lyme bacterium, Borrelia burgdorferi
Geographic range expansion and population growth of vector-borne pathogens are regulated by the migration of their arthropod vectors. Recent climate and land-use changes have produced alterations in the geographic range and population size of blacklegged ticks (Ixodes scapularis) and the pathogens …
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The Functional Role for Chromatin Loops in Gene Expression Control During Human Neuron Maturation
… higher-order chromatin loops, CTCF occupancy, and mRNA levels in post-mitotic human neurons remains an open question. Here, we summarize the field of epigenetics and chromatin in neuroscience, examine neural model systems, and build an auxin-inducible degron to deplete the architectural protein …
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ELUCIDATING THE MOLECULAR DETERMINANTS OF P53-MEDIATED PLEIOTROPIC EFFECTS IN SMALL CELL LUNG CANCER
… (SCLC) is the most lethal subtype of lung cancer and comprises ~15% of all lung cancer cases. Together with the retinoblastoma (Rb) tumor suppressor, p53 is inactivated in the vast majority (>90%) of SCLC cases. p53 is a pleiotropic tumor suppressor gene that responds to a wide array of genotoxic …
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Investigating Transcription Factor Networks That Drive Biological Clocks and Oscillators
… laboratory. The 24-hour</p><p>circadian rhythm and the approximately 75-minute cell cycle of a budding yeast cell are</p><p>both examples of dynamical processes that contain precisely ordered events, repeating</p><p>over each cycle. Organisms utilize such biological clock processes to time a …
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Identifying and Characterizing Non-Coding RNAs in the Dinoflagellate <i>Karenia brevis</i>
<p>When algal cells proliferate and accumulate in marine and fresh water systems, they form algal blo'oms. The majority of these blooms are beneficial, but a significant number are detrimental and are known as harmful algal blooms (HABs). A number of negative effects, including closing of …
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Risk Perception Among BRCA1 and BRCA2 Mutation Negative Patients
… is intended to give patients a clearer understanding of their individual cancer risk. Testing negative for BRCA1 and BRCA2 mutations does not completely eliminate the heritable component of cancer, nor does it eliminate the risk to relatives of affected women. This increased risk may be …
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